2023
Comparative Genomics of Bacillus subtilis Phages Related to phiNIT1 from Desert Soils of the Southwest United States
Vill A, Delesalle V, Magness L, Chaudhry B, Lichty K, Strine M, Guffey A, DeCurzio J, Krukonis G. Comparative Genomics of Bacillus subtilis Phages Related to phiNIT1 from Desert Soils of the Southwest United States. PHAGE 2023, 4: 173-180. DOI: 10.1089/phage.2023.0027.Peer-Reviewed Original ResearchGenomic structureBacillus phagesBacillus subtilis phageGram-positive bacteriumPathogenic Bacillus speciesDiverse genomesIntergenic regionSequence similarityGenetic diversityRepeat sequencesProtein familyRepresentative phagesPhageB. subtilisBacillus subtilisHost rangeBacillus speciesGenomeVirion structureCapsid structureDesert soilsTail lengthSequenceMyovirusesLysis assay
2021
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms
Huston NC, Wan H, Strine MS, de Cesaris Araujo Tavares R, Wilen CB, Pyle AM. Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms. Molecular Cell 2021, 81: 584-598.e5. PMID: 33444546, PMCID: PMC7775661, DOI: 10.1016/j.molcel.2020.12.041.Peer-Reviewed Original ResearchConceptsRNA structureSecondary structureRNA virusesSARS-CoV-2 RNA genomeNovel regulatory motifsSingle-nucleotide resolutionDownstream functional analysisRNA drug targetsPositive-sense RNA virusesGenome architectureGenomic structureEvolutionary analysisRegulatory motifsSARS-CoV-2 genomeViral life cycleRNA genomeFunctional analysisGenomeDrug targetsPrimer designInfected cellsViral RNADepth structural analysisLife cycleΒ-coronavirus