Featured Publications
Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical Inpatients
Han L, McCusker J, Cole M, Abrahamowicz M, Primeau F, Elie M. Use of Medications With Anticholinergic Effect Predicts Clinical Severity of Delirium Symptoms in Older Medical Inpatients. JAMA Internal Medicine 2001, 161: 1099-1105. PMID: 11322844, DOI: 10.1001/archinte.161.8.1099.Peer-Reviewed Original ResearchConceptsDelirium severityACH medicationsMedication exposureDelirium symptomsMedical inpatientsInpatients 65 yearsModifiable risk factorsOlder medical inpatientsUse of medicationsPresence of dementiaElderly medical inpatientsMixed linear regression modelsAnticholinergic medicationsACh effectsAnticholinergic effectsMedication usePrevalent deliriumDelirium IndexRisk factorsClinical severityMedicationsDeliriumSymptom severityLongitudinal associationsSeverityCumulative Anticholinergic Exposure Is Associated with Poor Memory and Executive Function in Older Men
Han L, Agostini JV, Allore HG. Cumulative Anticholinergic Exposure Is Associated with Poor Memory and Executive Function in Older Men. Journal Of The American Geriatrics Society 2008, 56: 2203-2210. PMID: 19093918, PMCID: PMC3952110, DOI: 10.1111/j.1532-5415.2008.02009.x.Peer-Reviewed Original ResearchConceptsTotal anticholinergic burdenCumulative anticholinergic exposureOlder menAnticholinergic medicationsAnticholinergic burdenAnticholinergic exposureCumulative exposureVeterans Affairs primary care clinicsExecutive functionAnticholinergic medication useDeleterious adverse effectsProspective cohort studySeverity of hypertensionCommunity-dwelling menPrimary care clinicsDaily Living ScalePotential risk factorsPrescription of drugsAnticholinergic scoreCohort studyMultiple medicationsAnticholinergic effectsMedication useCare clinicsPhysical function
2021
Association Between Potentially Inappropriate Medications and 30-Day Post–Hospital Discharge Outcomes in US Veterans
Allore HG, Gnjidic D, Skanderson M, Han L. Association Between Potentially Inappropriate Medications and 30-Day Post–Hospital Discharge Outcomes in US Veterans. Annals Of Pharmacotherapy 2021, 56: 256-263. PMID: 34282638, PMCID: PMC8770754, DOI: 10.1177/10600280211032072.Peer-Reviewed Original ResearchConceptsAdjusted hazard ratioRisk of mortalityHospital dischargeMean ageAcute care hospital readmissionPrimary care clinic visitsCohort's mean agePrevalence of PIMsInappropriate medication useRisk of readmissionHospital discharge outcomesEmergency room visitsHealth care utilizationAdverse drug eventsCentral nervous systemCause mortalityInappropriate medicationsPIM useClinic visitsHazard ratioProspective cohortDischarge outcomesHospital readmissionMedication useOlder inpatientsPain, Complex Chronic Conditions and Potential Inappropriate Medication in People with Dementia. Lessons Learnt for Pain Treatment Plans Utilizing Data from the Veteran Health Administration
Husebo BS, Kerns RD, Han L, Skanderson M, Gnjidic D, Allore HG. Pain, Complex Chronic Conditions and Potential Inappropriate Medication in People with Dementia. Lessons Learnt for Pain Treatment Plans Utilizing Data from the Veteran Health Administration. Brain Sciences 2021, 11: 86. PMID: 33440668, PMCID: PMC7827274, DOI: 10.3390/brainsci11010086.Peer-Reviewed Original ResearchChronic complex conditionsSevere pain intensityVeterans Health AdministrationPain intensityHealth AdministrationDiscontinuation of opioidsInappropriate pain managementPain treatment planPotential inappropriate medicationsInappropriate medication useComplex chronic conditionsNon-pharmacological approachesImportant risk factorAdverse drug reactionsFinal analytic sampleAnalgesic efficacyInappropriate medicationsOpioid medicationsPain medicationMedication usePain managementPersistent painChronic painMedical illnessOutpatient visits
2020
0852 Geriatric Health Conditions And The Combined Outcome Of Poor Sleep Quality With Objective Short Sleep Duration
Miner B, Fragoso C, Han L, Yaggi H, Redeker N, Stone K. 0852 Geriatric Health Conditions And The Combined Outcome Of Poor Sleep Quality With Objective Short Sleep Duration. Sleep 2020, 43: a324-a325. DOI: 10.1093/sleep/zsaa056.848.Peer-Reviewed Original ResearchShort sleep durationPoor sleep qualityObjective short sleep durationPittsburgh Sleep Quality IndexSleep qualitySleep durationHealth conditionsMedication useOsteoporotic fracturesUnadjusted oddsPhysical impairmentClaude D. Pepper Older Americans Independence CenterCognitive impairmentCombined outcomeAmerican AcademyMean age 76 yearsMean age 84 yearsAverage total sleep timeMen Sleep StudyAge 76 yearsAge 84 yearsSleep Quality IndexHigh-risk phenotypeCross-sectional associationsTotal sleep time0855 Primary Sleep Disorders And The Combined Outcome Of Poor Sleep Quality With Objective Short Sleep Duration In Older Persons
Miner B, Fragoso C, Han L, Stone K, Redeker N, Yaggi H. 0855 Primary Sleep Disorders And The Combined Outcome Of Poor Sleep Quality With Objective Short Sleep Duration In Older Persons. Sleep 2020, 43: a325-a326. DOI: 10.1093/sleep/zsaa056.851.Peer-Reviewed Original ResearchPrimary sleep disordersShort sleep durationPoor sleep qualityHigh-risk phenotypeSleep disordersSleep qualityOlder personsOsteoporotic fracturesMultivariable modelUnadjusted modelsSleep durationClaude D. Pepper Older Americans Independence CenterCombined outcomeObjective short sleep durationPittsburgh Sleep Quality Index scoreSelf-reported chronic conditionsMultivariate logistic regression modelAverage total sleep timeMen Sleep StudyCross-sectional associationsTotal sleep timeQuality Index scoresLogistic regression modelsMedication usePsychiatric comorbidity
2017
0755 LONGITUDINAL ASSOCIATIONS OF RISK FACTORS WITH INSOMNIA SEVERITY IN OLDER PERSONS
Miner B, Redeker N, Yaggi H, Van Ness P, Han L, Gill T, Fragoso C. 0755 LONGITUDINAL ASSOCIATIONS OF RISK FACTORS WITH INSOMNIA SEVERITY IN OLDER PERSONS. Sleep 2017, 40: a280-a280. DOI: 10.1093/sleepj/zsx050.754.Peer-Reviewed Original ResearchPrimary sleep disordersCommunity-dwelling personsMean ISI scorePrecipitating Events ProjectRisk factorsInsomnia severityRace/ethnicityMedication useSmoking statusCardiorespiratory diseaseFemale sexSleep disordersISI scoresDepressive symptomsCognitive impairmentOlder personsLongitudinal associationsNumber of medicationsInsomnia Severity IndexCardiorespiratory conditionsInsomnia managementTherapeutic priorityNeuropsychologic impairmentSociodemographic factorsSignificant association
2016
Dyspnea in Community‐Dwelling Older Persons: A Multifactorial Geriatric Health Condition
Miner B, Tinetti ME, Van Ness PH, Han L, Leo‐Summers L, Newman AB, Lee PJ, Fragoso C. Dyspnea in Community‐Dwelling Older Persons: A Multifactorial Geriatric Health Condition. Journal Of The American Geriatrics Society 2016, 64: 2042-2050. PMID: 27549914, PMCID: PMC5073004, DOI: 10.1111/jgs.14290.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnkle Brachial IndexBody Mass IndexCausalityComorbidityCross-Sectional StudiesDyspneaEchocardiographyElectric ImpedanceFemaleGeriatric AssessmentHumansIndependent LivingMaleMental CompetencyRespiratory Function TestsRisk FactorsSeverity of Illness IndexStatistics as TopicUnited StatesConceptsBody mass indexSevere dyspneaOlder personsChair standCommunity-dwelling older personsMultivariable logistic regression modelHealth conditionsWhole body muscle massMini-Mental State ExaminationAnkle-brachial indexEpidemiologic Studies Depression ScaleRespiratory muscle weaknessMaximal inspiratory pressureVentricular ejection fractionCardiovascular Health StudyCommunity-dwelling personsDiastolic cardiac dysfunctionLogistic regression modelsGrip weaknessSerum hemoglobinBlood pressureDyspnea severityEjection fractionMedication useCardiac dysfunction
2014
Antihypertensive Medications and Serious Fall Injuries in a Nationally Representative Sample of Older Adults
Tinetti ME, Han L, Lee DS, McAvay GJ, Peduzzi P, Gross CP, Zhou B, Lin H. Antihypertensive Medications and Serious Fall Injuries in a Nationally Representative Sample of Older Adults. JAMA Internal Medicine 2014, 174: 588-595. PMID: 24567036, PMCID: PMC4136657, DOI: 10.1001/jamainternmed.2013.14764.Peer-Reviewed Original ResearchConceptsSerious fall injuriesAdjusted hazard ratioAntihypertensive medicationsMultiple chronic conditionsFall injuriesAntihypertensive groupHazard ratioOlder adultsChronic conditionsAntihypertensive medication classesStandardized daily doseAntihypertensive medication useCommunity-living adultsPropensity score adjustmentTraumatic brain injuryHealthy older adultsMedication intensityCardiovascular eventsMedication classesDaily doseHip fractureMedication useNationally Representative SampleHead injuryBrain injury
2013
The impact of medication use on symptom burden in older patients with multiple medical morbidities
Han M, Tinetti M, Agostini J, Han L, Lee H, Walke L. The impact of medication use on symptom burden in older patients with multiple medical morbidities. Journal Of Clinical Gerontology And Geriatrics 2013, 4: 84-88. DOI: 10.1016/j.jcgg.2013.03.002.Peer-Reviewed Original ResearchSymptom burdenMedical morbidityMedication useVeterans Affairs primary care clinicsGreater medication useMultiple medical morbiditiesNumber of medicationsMedical record reviewPrimary care clinicsSurvey of patientsAdverse drug eventsCross-sectional studySeverity of symptomsAdditional medicationOlder patientsCare clinicsRecord reviewRoutine appointmentsDrug eventsChi-square analysisMorbiditySevere symptomsMedicationsLinear regression analysisSymptom categories
2007
Association Between Antihypertensive Medication Use and Non-cardiovascular Outcomes in Older Men
Agostini JV, Tinetti ME, Han L, Peduzzi P, Foody JM, Concato J. Association Between Antihypertensive Medication Use and Non-cardiovascular Outcomes in Older Men. Journal Of General Internal Medicine 2007, 22: 1661-1667. PMID: 17899299, PMCID: PMC2219823, DOI: 10.1007/s11606-007-0388-9.Peer-Reviewed Original ResearchConceptsNon-cardiovascular outcomesAntihypertensive medication useAntihypertensive medicationsMedication useAdverse effectsOlder menCommunity-living older menVeterans Affairs primary care clinicsEpidemiologic Studies-Depression scoreOlder adultsMultiple antihypertensive medicationsPhysical performancePrimary care clinicsDrug adverse effectsRoutine clinical practiceCES-D scoresHigh cumulative exposureRelated adverse effectsTrail Making BMedication intensityTest Part BHypertensive menCerebrovascular effectsCohort studyBlood pressureEffects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults
Agostini JV, Tinetti ME, Han L, McAvay G, Foody JM, Concato J. Effects of Statin Use on Muscle Strength, Cognition, and Depressive Symptoms in Older Adults. Journal Of The American Geriatrics Society 2007, 55: 420-425. PMID: 17341246, DOI: 10.1111/j.1532-5415.2007.01071.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCognitionCohort StudiesComorbidityConnecticutDepressionDrug Therapy, CombinationDrug UtilizationFemaleGeriatric AssessmentHumansHydroxymethylglutaryl-CoA Reductase InhibitorsLongitudinal StudiesMaleMuscle StrengthNeuropsychological TestsPrimary Health CareProspective StudiesRisk AssessmentVeteransConceptsStatin usersMuscle strengthTest Part BStatin useDepression scoresEpidemiologic Studies Depression Scale scoreOutpatient primary care clinicsOlder adultsConcomitant medication useProximal muscle strengthObservational cohort studyPeripheral vascular diseasePrimary care clinicsDepression Scale scoresHigh-risk participantsHydroxymethyl glutaryl coenzymeCommunity-dwelling veteransCommunity-dwelling male participantsGreater comorbidityStatin therapyCohort studyMedian durationStatin prescriptionMedication useCare clinics