2006
Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
Rakoff-Nahoum S, Hao L, Medzhitov R. Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis. Immunity 2006, 25: 319-329. PMID: 16879997, DOI: 10.1016/j.immuni.2006.06.010.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseToll-like receptorsAbsence of TLRDevelopment of IBDEtiology of IBDImmune systemIL-10-deficient miceImmune suppressive mechanismsInnate immune recognitionHost immune systemBowel diseaseIntestinal inflammationColitisCommensal microfloraImmune recognitionMiceMultiple mechanismsDisease susceptibilityDifferential rolesReceptorsInflammationInterleukinMicrofloraEtiologyDisease
2005
Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response
Peng T, Hao L, Madri JA, Su X, Elias JA, Stahl GL, Squinto S, Wang Y. Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response. Journal Of Clinical Investigation 2005, 115: 1590-1600. PMID: 15902311, PMCID: PMC1090470, DOI: 10.1172/jci22906.Peer-Reviewed Original ResearchConceptsAirway hyperresponsivenessAirway inflammationContribution of C5Airway responsesDevelopment of AHRHarmful inflammatory mediatorsRole of C5C5-deficient miceCourse of diseaseDownstream inflammatory cascadesInnate immune systemPotential clinical approachCritical checkpointAllergen provocationComplement component C5Inflammatory mediatorsInflammatory cascadeAirway lumenInflammatory cellsC5 inhibitionNonspecific stimuliClinical approachImmune systemInflammationC5b-9
2002
Murine model of gastrointestinal ischemia associated with complement-dependent injury
Zhao H, Montalto MC, Pfeiffer KJ, Hao L, Stahl GL. Murine model of gastrointestinal ischemia associated with complement-dependent injury. Journal Of Applied Physiology 2002, 93: 338-345. PMID: 12070223, DOI: 10.1152/japplphysiol.00159.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsColoring AgentsComplement C5Complement System ProteinsDigestive SystemGastrointestinal DiseasesImmunohistochemistryIntercellular Adhesion Molecule-1IntestinesL-Lactate DehydrogenaseLungMaleMiceMice, Inbred C57BLMice, KnockoutPeroxidaseRegional Blood FlowReperfusion InjuryReproducibility of ResultsReverse Transcriptase Polymerase Chain ReactionConceptsRemote tissue injuryTissue injuryGastrointestinal ischemiaMurine modelComplement-mediated tissue injuryIntercellular adhesion molecule-1 mRNAAnti-C5 treatmentComplement-dependent injuryInflammatory protein-2 mRNAIschemia-reperfusion injuryAttenuates tissue injuryNew murine modelC5 monoclonal antibodyNeutrophil accumulationNeutrophil infiltrationNeutrophil recruitmentProtein-2 mRNAChemokine expressionActivate complementInjuryAdherence moleculesComplement activationMonoclonal antibodiesProtein expressionLactate dehydrogenase