2006
Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo
Patel AB, de Graaf RA, Martin DL, Battaglioli G, Behar KL. Evidence that GAD65 mediates increased GABA synthesis during intense neuronal activity in vivo. Journal Of Neurochemistry 2006, 97: 385-396. PMID: 16539672, DOI: 10.1111/j.1471-4159.2006.03741.x.Peer-Reviewed Original ResearchMeSH Keywords4-Aminobutyrate TransaminaseAnimalsAnticonvulsantsBicucullineBlotting, WesternDose-Response Relationship, DrugGABA AntagonistsGamma-Aminobutyric AcidGlutamate DecarboxylaseIsoenzymesMagnetic Resonance SpectroscopyMaleProtein IsoformsRatsRats, Sprague-DawleySeizuresTime FactorsVigabatrin
1996
Low brain GABA level is associated with poor seizure control
Petroff O, Rothman D, Behar K, Mattson R. Low brain GABA level is associated with poor seizure control. Annals Of Neurology 1996, 40: 908-911. PMID: 9007096, DOI: 10.1002/ana.410400613.Peer-Reviewed Original ResearchConceptsLower GABA levelsBrain GABA levelsLower brain GABA levelsPoor seizure controlGABA levelsSeizure controlRecent seizuresGamma-aminobutyric acid concentrationComplex partial seizuresPartial seizuresEpileptic syndromesEpileptic focusOccipital lobeCerebrospinal fluidPatientsSeizuresSignificant associationMagnetic resonanceVivo measurementsSurface coilLevelsEpilepsySyndromeGABAAcid concentration
1989
Effects of Hypercarbia and Porta-Caval Shunting on Amino Acids and High Energy Phosphates of the Rat Brain: a 1H and 31P NMR Study
Behar K, Fitzpatrick S. Effects of Hypercarbia and Porta-Caval Shunting on Amino Acids and High Energy Phosphates of the Rat Brain: a 1H and 31P NMR Study. Experimental Biology And Medicine 1989, 189-200. DOI: 10.1007/978-1-4612-4506-3_13.Peer-Reviewed Original ResearchRat brainCerebral amino acidsEffects of hypercarbiaConcentration of glutamateHigh-energy phosphatesPorta-cavalCerebral hypoxiaMetabolic encephalopathiesHypercarbic acidosisAcute hyperammonemiaCerebral glutamateIntracellular acidosisEnergy phosphatesIncrease of glutamineHypercarbiaEncephalopathyAcidosisHyperammonemiaGlutamateBrainAmino acidsIntracellularIschemiaSeizuresShunting