Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase‐deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling
Chowdhury GM, Gupta M, Gibson KM, Patel AB, Behar KL. Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase‐deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling. Journal Of Neurochemistry 2007, 103: 2077-2091. PMID: 17854388, DOI: 10.1111/j.1471-4159.2007.04887.x.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAmino AcidsAnimalsAnimals, NewbornBlood GlucoseCarbon IsotopesCerebral CortexGamma-Aminobutyric AcidGlutamate-Ammonia LigaseGlutamic AcidGlutamineImage Processing, Computer-AssistedMagnetic Resonance SpectroscopyMiceMice, KnockoutNeurogliaSodium OxybateSuccinate-Semialdehyde DehydrogenaseTime FactorsConceptsSSADH deficiencyLevels of GABAGlutamate/glutamine cyclingSuccinic semialdehyde dehydrogenase‐deficient miceGlutamine-C4Cerebral metabolismCerebral glucoseCortical extractsGlial dysfunctionIntraperitoneal infusionSuccinic semialdehyde dehydrogenaseGABA-C2Excessive elevationNeurotransmitter glutamateGABA synthesisGABAMiceGHBGlutamateGlutamine metabolismAspartate C3GliaCortexGlutamine cyclingGlial substrate