Utilizing protein structure to identify non-random somatic mutations
Ryslik GA, Cheng Y, Cheung KH, Modis Y, Zhao H. Utilizing protein structure to identify non-random somatic mutations. BMC Bioinformatics 2013, 14: 190. PMID: 23758891, PMCID: PMC3691676, DOI: 10.1186/1471-2105-14-190.Peer-Reviewed Original ResearchConceptsProtein Data BankProtein structureSomatic mutationsTertiary structureDimensional protein structureProtein tertiary structureTertiary protein structureDriver mutationsMutation clustersTumor suppressorProteinMutational clusteringPharmacological successMutationsCancer proteinsNovel clusterMutational clustersOncogeneSingle strandsR packageData BankCurrent methodologiesGenomeEIF2AK2Suppressor