Featured Publications
Face Transplantation in a Black Patient — Racial Considerations and Early Outcomes
Kauke M, Panayi AC, Tchiloemba B, Diehm YF, Haug V, Kollar B, Perry B, Singhal D, Sinha I, Riella LV, Annino DJ, Pomahac B. Face Transplantation in a Black Patient — Racial Considerations and Early Outcomes. New England Journal Of Medicine 2021, 384: 1075-1076. PMID: 33730460, PMCID: PMC8182672, DOI: 10.1056/nejmc2033961.Peer-Reviewed Original Research
2024
Risk of Postoperative Complications After Total Hip and Total Knee Arthroplasty in Behcet Syndrome Patients
Ratnasamy P, Diatta F, Allam O, Kauke-Navarro M, Grauer J. Risk of Postoperative Complications After Total Hip and Total Knee Arthroplasty in Behcet Syndrome Patients. JAAOS Global Research And Reviews 2024, 8: e24.00040. PMID: 39392934, PMCID: PMC11469891, DOI: 10.5435/jaaosglobal-d-24-00040.Peer-Reviewed Original ResearchConceptsBehcet's syndromeAdverse eventsTotal knee arthroplastyMultivariate analysisRevision surgeryRisk of postoperative complicationsRisk of perioperative adverse eventsTotal hip arthroplastyLog-rank testElixhauser Comorbidity Index scoreRetrospective cohort studyMultisystem autoimmune disorderPostoperative adverse eventsPerioperative adverse eventsComorbidity Index scoreNational administrative databaseKnee arthroplastyTotal knee arthroplasty patientsPostoperative complicationsNo significant differencePatient ageAutoimmune disordersPerioperative managementSyndrome patientsCohort studyIncreased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty
Sanchez J, Rancu A, Diatta F, Jonnalagadda A, Dhodapkar M, Knoedler L, Kauke-Navarro M, Grauer J. Increased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e24.00102. PMID: 38722914, PMCID: PMC11081627, DOI: 10.5435/jaaosglobal-d-24-00102.Peer-Reviewed Original ResearchConceptsRevision-free survivalDay of surgeryAdverse eventsTSA patientsIncreased riskMultivariate analysisOdds ratioIncreased risk of adverse eventsUrinary tract infectionLog-rank testRisk of adverse eventsSurgical site infectionSevere adverse eventsEffective treatment optionAcute kidney injuryDeep vein thrombosisMinor adverse eventsNon-fibromyalgia patientsEnd-stage glenohumeral osteoarthritisAssociation of fibromyalgiaIncreased odds ratioTotal shoulder arthroplastyShoulder infectionPulmonary embolismTract infections
2023
Incidence and Risk Factors of Postoperative Complications After Rhinoplasty: A Multi-Institutional ACS-NSQIP Analysis
Knoedler S, Knoedler L, Wu M, Haug V, Broer P, Kauke-Navarro M, Hundeshagen G, Prantl L, Orgill D, Panayi A. Incidence and Risk Factors of Postoperative Complications After Rhinoplasty: A Multi-Institutional ACS-NSQIP Analysis. Journal Of Craniofacial Surgery 2023, 34: 1722-1726. PMID: 37487058, DOI: 10.1097/scs.0000000000009553.Peer-Reviewed Original ResearchConceptsLow serum albuminSurgical adverse eventsAdverse eventsRisk factorsPostoperative outcomesASA scoreComplication rateMale sexSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databasePreoperative nutritional optimizationSuperficial incisional infectionAverage patient ageHigher ASA scoreImprovement Program databasePreoperative laboratory valuesACS-NSQIP AnalysisMulti-institutional analysisSingle-institution reportsIncisional infectionPostoperative complicationsPreoperative albuminComplication occurrenceMost patients
2021
Long-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature
Tchiloemba B, Kauke M, Haug V, Abdulrazzak O, Safi AF, Kollar B, Pomahac B. Long-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature. Transplantation 2021, 105: 1869-1880. PMID: 33148976, DOI: 10.1097/tp.0000000000003513.Peer-Reviewed Original ResearchConceptsSystematic reviewAcute cell-mediated rejectionPositive risk-benefit ratioRecurrent acute rejection episodesLong-term outcome dataAcute rejection episodesChronic vascular rejectionFirst year posttransplantImmunosuppression-related complicationsCell-mediated rejectionSingle-center experiencePubMed/MEDLINE databaseLong-term outcomesRisk-benefit ratioEnglish full-text articlesQuality of lifeFull-text articlesAcute rejectionAllograft lossChronic rejectionRejection episodesVascular rejectionInfectious complicationsInfectious episodesMetabolic complicationsDonor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool
Kauke M, Haug V, Obed D, Diehm Y, Tchiloemba B, Safi AF, Pomahac B. Donor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool. Plastic & Reconstructive Surgery 2021, 148: 194-202. PMID: 34181616, DOI: 10.1097/prs.0000000000008094.Peer-Reviewed Original ResearchConceptsDonor poolHepatitis CUnited NetworkPotential donorsEpstein-Barr virus seropositivityCytomegalovirus-seropositive donorsUnderrepresented patient groupsOrgan Sharing databaseFacial Vascularized Composite AllotransplantationHigh-risk characteristicsVascularized Composite AllotransplantationActual wait timesAllotransplant patientsSeronegative patientsSeropositive donorsMost patientsAllotransplant recipientsPatient characteristicsRecipient matchingSharing databasePositive donorsPatient groupVirus seropositivityOrgan SharingOrgan donorsThe modified 5-item frailty index is a predictor of perioperative risk in head and neck microvascular reconstruction: An analysis of 3795 cases
Panayi AC, Haug V, Kauke-Navarro M, Foroutanjazi S, Diehm YF, Pomahac B. The modified 5-item frailty index is a predictor of perioperative risk in head and neck microvascular reconstruction: An analysis of 3795 cases. American Journal Of Otolaryngology 2021, 42: 103121. PMID: 34171698, DOI: 10.1016/j.amjoto.2021.103121.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnastomosis, SurgicalDiabetes MellitusFemaleForecastingFrailtyHeadHeart FailureHumansHypertensionLength of StayMaleMicrovesselsMiddle AgedNeckOperative TimePlastic Surgery ProceduresPostoperative ComplicationsPulmonary Disease, Chronic ObstructiveSeverity of Illness IndexSurgical FlapsTreatment OutcomeConceptsNeck microvascular reconstructionMFI-5Microvascular reconstructionMFI scoreSubgroup analysisNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseChronic obstructive pulmonary diseaseFrailty index-5Non-home dischargeImprovement Program databaseAverage operative timeCongestive heart failureObstructive pulmonary diseasePost-operative outcomesPre-operative identificationPost-operative supportTerms of demographicsHospital stayPerioperative riskUnplanned readmissionHome dischargePostoperative outcomesYounger patientsFrailty indexDynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants.
Kauke M, Safi AF, Palmer WJ, Kollar B, Nelms L, Tchiloemba B, Haug V, Pomahac B. Dynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants. Plastic & Reconstructive Surgery 2021, 147: 722-727. PMID: 33620943, DOI: 10.1097/prs.0000000000007673.Peer-Reviewed Original ResearchConceptsMaxillary sinusFace transplant recipientsTransplant recipientsAllograft rejectionTissue changesBiopsy-proven allograft rejectionDiagnosis of rejectionMedication side effectsMaxillary sinus mucosaIndividualized treatment strategiesTissue allograft rejectionVascularized composite allotransplantsFace transplant patientsDynamic tissue changesRadiologic biomarkersRejection gradeTransplant patientsMucosal swellingSinonasal tractSinus changesSinus mucosaClinical managementTomographic scanPathologic changesTreatment strategies
2020
Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation
Kauke-Navarro M, Tchiloemba B, Haug V, Kollar B, Diehm Y, Safi AF, Treister NS, Annino DJ, Marty FM, Lian CG, Murphy GF, Pomahac B. Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 1562-1571. PMID: 33376080, DOI: 10.1016/j.bjps.2020.11.028.Peer-Reviewed Original ResearchConceptsNasal mucous membraneMucous membranesMucosal inflammationMucosal lesionsBanff gradeInflammatory mucosal lesionsUlceration/erosionRetrospective cohort studyClinico-pathologic variablesMucosal rejectionCohort studyCutaneous changesIndependent predictorsMucosal assessmentOral lesionsSkin rejectionSinonasal mucosaCommon lesionsMedical recordsUnivariate analysisCutaneous pathologyBuccal mucosaNasal vestibuleOral cavityComposite allotransplantationCombined (endo-)vascular intervention and microsurgical lower extremity free flap reconstruction—A propensity score matching analysis in 5386 ACS-NSQIP patients
Haug V, Kadakia N, Panayi AC, Kauke M, Hundeshagen G, Diehm Y, Fischer S, Hirche C, Kneser U, Pomahac B. Combined (endo-)vascular intervention and microsurgical lower extremity free flap reconstruction—A propensity score matching analysis in 5386 ACS-NSQIP patients. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 1031-1040. PMID: 33436337, DOI: 10.1016/j.bjps.2020.10.045.Peer-Reviewed Original ResearchConceptsFree flap reconstructionLower extremity free flap reconstructionFlap reconstructionLimb amputationNational Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseAnesthesiology physical status classificationQuality Improvement Program databaseMicrosurgical free flap reconstructionPropensity scoreACS-NSQIP patientsLower limb perfusionPreoperative steroid usePropensity-matched cohortImprovement Program databaseModifiable risk factorsPeripheral artery diseasePhysical status classificationCareful preoperative assessmentSick patient populationLower limb amputationLower extremity salvageLower limb reconstructionFree flap transferFree tissue transferHypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours.
Haug V, Kollar B, Tasigiorgos S, Endo Y, Kauke M, Safi AF, Veeramani A, Abdulrazzak O, Bausk B, Walt D, Pomahac B. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours. Transplantation 2020, 104: e260-e270. PMID: 32168040, DOI: 10.1097/tp.0000000000003221.Peer-Reviewed Original ResearchAccelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation
Kollar B, Rizzo NM, Borges TJ, Haug V, Abdulrazzak O, Kauke M, Safi AF, Lian CG, Marty FM, Rutherford AE, Mitchell RN, Murphy GF, Tullius SG, Riella LV, Pomahac B. Accelerated chronic skin changes without allograft vasculopathy: A 10-year outcome report after face transplantation. Surgery 2020, 167: 991-998. PMID: 32113580, DOI: 10.1016/j.surg.2020.01.010.Peer-Reviewed Original ResearchConceptsChronic skin changesDeath 10 yearsSkin changesAllograft vasculopathySensory functionAcute cellular rejection episodesLong-term kidney functionHepatitis C virus infectionFace transplantationCellular rejection episodesC virus infectionNumber of CD4Glomerular filtration rateLong-term outcomesLong-term motorSkin immune cellsAllograft vesselsRejection episodesImmunosuppressive therapyLiver cirrhosisKidney functionFiltration rateImmune cellsMedical recordsGrade IIMucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review.
Kauke M, Safi AF, Zhegibe A, Haug V, Kollar B, Nelms L, Palmer WJ, Tchiloemba B, Lian CG, Murphy GF, Pomahac B. Mucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review. Transplantation 2020, 104: 2616-2624. PMID: 32053572, DOI: 10.1097/tp.0000000000003171.Peer-Reviewed Original ResearchConceptsMucosal rejectionSystematic reviewRejection gradeMucosal biopsiesPatient managementComposite allotransplantationDiagnosis of rejectionFunction of patientsFacial Vascularized Composite AllotransplantationMeta-Analyses (PRISMA) guidelinesMEDLINE/PubMedPreferred Reporting ItemsVascularized Composite AllotransplantationPosttransplant periodBiopsy gradeSkin rejectionMucosa biopsiesAllograft skinAnimal studiesReporting ItemsBiopsyRejection processFacial allotransplantsMucosaTarget tissues
2019
MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study
Kollar B, Uffing A, Borges TJ, Shubin AV, Aoyama BT, Dagot C, Haug V, Kauke M, Safi AF, Talbot SG, Morelon E, Dakpe S, Pomahac B, Riella LV. MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study. Frontiers In Immunology 2019, 10: 2771. PMID: 31849957, PMCID: PMC6897344, DOI: 10.3389/fimmu.2019.02771.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-3MMP3 levelsNon-invasive biomarkersTransplant recipientsAcute rejectionHealthy controlsComposite allotransplantationRejection stateCandidate non-invasive biomarkersUpper extremity transplant recipientsSerum samplesAntibody-mediated rejectionKidney transplant recipientsSeverity of rejectionPre-transplant levelsAutoimmune skin diseaseLongitudinal serum samplesSkin disease patientsVascularized Composite AllotransplantationMulticenter validation studyFace transplant recipientsLarger validation studiesClinical VCARejection episodesVCA patientsDoes Meningioma Volume Correlate With Clinical Disease Manifestation Irrespective of Histopathologic Tumor Grade?
Kauke M, Safi AF, Stavrinou P, Krischek B, Goldbrunner R, Timmer M. Does Meningioma Volume Correlate With Clinical Disease Manifestation Irrespective of Histopathologic Tumor Grade? Journal Of Craniofacial Surgery 2019, 30: e799-e802. PMID: 31633669, DOI: 10.1097/scs.0000000000005845.Peer-Reviewed Original ResearchConceptsHigher tumor volumeTumor gradeTumor volumeClinical disease manifestationsHistopathological tumor gradeHistopathologic tumor gradeRadiological biomarkersClinical symptomsCystic degenerationTumor locationDisease manifestationsPeritumoral edemaTumor aggressivenessMeningioma volumeVolume correlateVolumetric analysisMass effectSemiautomatic image segmentationITK-SNAPEarly and late-recorded predictors of health-related quality of life of burn patients on long-term follow-up
Gojowy D, Kauke M, Ohmann T, Homann HH, Mannil L. Early and late-recorded predictors of health-related quality of life of burn patients on long-term follow-up. Burns 2019, 45: 1300-1310. PMID: 31176508, DOI: 10.1016/j.burns.2019.03.016.Peer-Reviewed Original ResearchConceptsSignificant independent predictor variablesTotal body surface areaHealth-related qualityIndependent predictor variablesHospital stayMechanical ventilationHand functionGeneral populationSummary scoresBurn Specific Health Scale-Brief (BSHS-B) questionnaireGeneric Short Form-36 (SF-36) questionnaireThickness burnsSingle-center cross-sectional studyMultivariate analysisShort Form-36 questionnaireObserver Scar Assessment ScaleIntentional burn injuriesMean burn sizePhysical summary scoreMental component scoreMental summary scoresLong-term outcomesPrimary outcome variableNorm scoresBody surface area
2018
Evaluation of Fronto-Orbital Advancement Using Titanium-Based Internal Fixation for Corrective Pediatric Craniofacial Surgery
Kreppel M, Kauke M, Grandoch A, Safi AF, Nickenig HJ, Zöller J. Evaluation of Fronto-Orbital Advancement Using Titanium-Based Internal Fixation for Corrective Pediatric Craniofacial Surgery. Journal Of Craniofacial Surgery 2018, 29: 1542-1545. PMID: 29916974, DOI: 10.1097/scs.0000000000004689.Peer-Reviewed Original ResearchConceptsFronto-orbital advancementPediatric craniofacial surgerySecondary surgeryEsthetic outcomeFixation systemRigid fixation systemsRate of complicationsCraniofacial surgeryInternal rigid fixationPlate fixation systemComplication rateSurgical drainsInternal fixationMean durationSecond HospitalSecondary interventionsMedical recordsInternal fixation systemWhitaker scoreRigid fixationSurgeryPatientsBone fragmentsComplicationsCranial vaultClinical evaluation of non-syndromic scaphocephaly surgically corrected with the procedure of total vertex craniectomy
Kreppel M, Kauke M, Safi AF, Grandoch A, Pocek-Behn N, Nickenig HJ, Zöller J. Clinical evaluation of non-syndromic scaphocephaly surgically corrected with the procedure of total vertex craniectomy. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1465-1469. PMID: 29960814, DOI: 10.1016/j.jcms.2018.05.057.Peer-Reviewed Original ResearchConceptsTime of surgeryStandardized operative techniqueSingle-surgeon approachMonths of ageReoperation rateMajor complicationsCorrective surgeryMean durationClinical evaluationSurgical correctionSurgical methodsOperative techniqueWhitaker scoreRetrospective evaluationSurgeon's approachCraniectomyAesthetic outcomeYoung individualsMonthsPatientsSurgeryScaphocephalyCategory IVCategory IOutcomesDoes volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma?
Safi AF, Kauke M, Jung H, Timmer M, Borggrefe J, Persigehl T, Nickenig HJ, Zinser M, Maintz D, Kreppel M, Zöller J. Does volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma? Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1013-1018. PMID: 29709330, DOI: 10.1016/j.jcms.2018.04.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersCarcinoma, Squamous CellChemoradiotherapyFemaleHumansLymph NodesLymphatic MetastasisMaleMicrosurgeryMiddle AgedMouth NeoplasmsMultivariate AnalysisNeckNeck DissectionNeoadjuvant TherapyNeoplasm Recurrence, LocalPrognosisRetrospective StudiesRisk FactorsTomography, X-Ray ComputedConceptsOral squamous cell carcinomaLymph node volumeSquamous cell carcinomaLocoregional recurrenceN classificationCell carcinomaNode volumeInclusion criteriaComputed tomographyTreatment-naive oral squamous cell carcinomaIpsilateral lymph node metastasisBetter risk stratification toolsComprehensive neck dissectionPathological N classificationCervical lymph nodesNegative resection marginsRetrospective chart reviewRisk stratification toolLymph node metastasisPreoperative computed tomographyVolumetric measurementsT4b classificationUnresectable diseaseLocoregional failureNeoadjuvant chemoradiotherapyThe importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller J, Kreppel M. The importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1007-1012. PMID: 29709331, DOI: 10.1016/j.jcms.2018.03.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Squamous CellChemoradiotherapyFemaleHumansKaplan-Meier EstimateLymph Node ExcisionLymph NodesLymphatic MetastasisMaleMandibleMiddle AgedMouth NeoplasmsMultivariate AnalysisNeck DissectionNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesRisk AssessmentConceptsOral squamous cell carcinomaSquamous cell carcinomaMandibular infiltrationLocoregional recurrenceCell carcinomaLymph nodesExclusion criteriaTreatment-naive oral squamous cell carcinomaImportance of lymphPathologic N classificationLymph node ratioPositive lymph nodesNegative resection marginsRetrospective chart reviewRisk stratification toolAssessment of prognosisConventional nodalT4b classificationUnresectable diseaseNeoadjuvant chemoradiotherapyPerioperative deathsSynchronous malignanciesChart reviewResection marginsClinicopathological characteristics