2020
Subaortic Membranes in Patients With Hereditary Hemorrhagic Telangiectasia and Liver Vascular Malformations
Kim AS, Henderson KJ, Pawar S, Kim MJ, Punjani S, Pollak JS, Fahey JT, Garcia‐Tsao G, Sugeng L, Young LH. Subaortic Membranes in Patients With Hereditary Hemorrhagic Telangiectasia and Liver Vascular Malformations. Journal Of The American Heart Association 2020, 9: e016197. PMID: 33054561, PMCID: PMC7763373, DOI: 10.1161/jaha.120.016197.Peer-Reviewed Original ResearchMeSH KeywordsActivin Receptors, Type IICardiac Output, HighDiscrete Subaortic StenosisEchocardiographyFemaleHeart Defects, CongenitalHeart FailureHumansLiverMaleMiddle AgedMutationPrognosisRetrospective StudiesSurvival AnalysisTelangiectasia, Hereditary HemorrhagicUnited StatesVascular MalformationsConceptsHigh-output cardiac failureHereditary hemorrhagic telangiectasiaLeft ventricular outflow tractVentricular outflow tractHemorrhagic telangiectasiaMild obstructionSubaortic membraneVascular malformationsOutflow tractActivin receptor-like kinase 1 mutationsHereditary hemorrhagic telangiectasia patientsLiver vascular malformationsMild aortic insufficiencyPulmonary artery pressureRight heart catheterizationCohort of patientsRetrospective observational analysisHigh cardiac outputKinase 1 mutationsArtery pressureHeart catheterizationPulmonary hypertensionAortic insufficiencyBackground PatientsTricuspid regurgitationGenotype–Phenotype Correlations in Children with HHT
Kilian A, Latino GA, White AJ, Clark D, Chakinala MM, Ratjen F, McDonald J, Whitehead K, Gossage JR, Lin D, Henderson K, Pollak J, McWilliams JP, Kim H, Lawton MT, Faughnan ME, . Genotype–Phenotype Correlations in Children with HHT. Journal Of Clinical Medicine 2020, 9: 2714. PMID: 32842615, PMCID: PMC7565052, DOI: 10.3390/jcm9092714.Peer-Reviewed Original ResearchBrain vascular malformationsHereditary hemorrhagic telangiectasiaPulmonary arteriovenous malformationsGenotype-phenotype correlationVascular malformationsArteriovenous malformationsHHT patientsCentral nervous systemRare autosomal dominant diseaseChi-square testAutosomal dominant diseaseGastrointestinal bleedingPediatric patientsMucocutaneous telangiectasiaHemorrhagic telangiectasiaGreater prevalenceNervous systemPatientsPhenotypic presentationDominant diseaseMalformationsAdultsChildrenTelangiectasiaMutations
2018
Applicability of the Curaçao Criteria for the Diagnosis of Hereditary Hemorrhagic Telangiectasia in the Pediatric Population
Pahl KS, Choudhury A, Wusik K, Hammill A, White A, Henderson K, Pollak J, Kasthuri RS. Applicability of the Curaçao Criteria for the Diagnosis of Hereditary Hemorrhagic Telangiectasia in the Pediatric Population. The Journal Of Pediatrics 2018, 197: 207-213. PMID: 29655863, DOI: 10.1016/j.jpeds.2018.01.079.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaClinical Curaçao criteriaCuraçao criteriaPediatric populationHemorrhagic telangiectasiaAge groupsDiagnosis of HHTGenetic testingMulticenter chart review6 A Novel Association Between High Red Blood Cell Alloimmunization Rates and Hereditary Hemorrhagic Telangiectasia (HHT)
Zheng Y, Pollak J, Henderson K, Hendrickson J, Tormey C. 6 A Novel Association Between High Red Blood Cell Alloimmunization Rates and Hereditary Hemorrhagic Telangiectasia (HHT). American Journal Of Clinical Pathology 2018, 149: s166-s166. DOI: 10.1093/ajcp/aqx149.375.Peer-Reviewed Original ResearchHereditary hemorrhagic telangiectasiaAlloimmunization rateRBC transfusionHHT patientsHemorrhagic telangiectasiaRed blood cell transfusionFirst RBC transfusionMore RBC transfusionsNon-ABO alloantibodiesProphylactic antigen matchingRBC alloimmunization rateBlood cell transfusionMultiple arteriovenous malformationsStudent's t-testAutosomal dominant disorderCommon alloantibodiesHHT subjectsCell transfusionReferral centerControl patientsMale patientsAntigen matchingRetrospective studyAntibody screenPatient population
2015
Hemorrhage Rates From Brain Arteriovenous Malformation in Patients With Hereditary Hemorrhagic Telangiectasia
Kim H, Nelson J, Krings T, terBrugge K, McCulloch C, Lawton M, Young W, Faughnan M, Chakinala M, Gossage J, Henderson K, Iyer V, Kasthuri R, Lin D, Mager J, McWilliams J, McDonald J, Pawlikowska L, Pollak J, Ratjen F, Swanson K, Vethanayagam D, White A, White R, Wilcox P. Hemorrhage Rates From Brain Arteriovenous Malformation in Patients With Hereditary Hemorrhagic Telangiectasia. Stroke 2015, 46: 1362-1364. PMID: 25858236, PMCID: PMC4415515, DOI: 10.1161/strokeaha.114.007367.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAneurysm, RupturedChildChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornIntracranial Arteriovenous MalformationsIntracranial HemorrhagesMaleMiddle AgedRecurrenceRetrospective StudiesSocioeconomic FactorsSurvival AnalysisTelangiectasia, Hereditary HemorrhagicYoung AdultConceptsHereditary hemorrhagic telangiectasiaBrain arteriovenous malformationsICH rateArteriovenous malformationsHemorrhage rateHemorrhagic telangiectasiaHigher ICH ratesIntracranial hemorrhage rateMajority of patientsICH presentationSymptomatic casesSystemic diseaseICH eventsMean ageAsymptomatic screeningMucocutaneous telangiectasiaHHT patientsHigh riskUnruptured casesPatientsMalformationsDiagnosisTelangiectasiaRehemorrhageEpistaxis
2013
Bevacizumab: Finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia
Young LH, Henderson KJ, White RI, Garcia‐Tsao G. Bevacizumab: Finding its niche in the treatment of heart failure secondary to liver vascular malformations in hereditary hemorrhagic telangiectasia. Hepatology 2013, 58: 442-445. PMID: 23686865, DOI: 10.1002/hep.26472.Commentaries, Editorials and LettersConceptsHereditary hemorrhagic telangiectasiaHeart failureVascular malformationsHemorrhagic telangiectasiaMalformations
2012
Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: Gene–phenotype correlations
Nishida T, Faughnan ME, Krings T, Chakinala M, Gossage JR, Young WL, Kim H, Pourmohamad T, Henderson KJ, Schrum SD, James M, Quinnine N, Bharatha A, terBrugge KG, White RI. Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: Gene–phenotype correlations. American Journal Of Medical Genetics Part A 2012, 158A: 2829-2834. PMID: 22991266, PMCID: PMC3610331, DOI: 10.1002/ajmg.a.35622.Peer-Reviewed Original ResearchMeSH KeywordsActivin Receptors, Type IIAdolescentAdultAgedAntigens, CDArteriovenous FistulaChildChild, PreschoolEndoglinFemaleGenetic Association StudiesHumansInfantInfant, NewbornIntracellular Signaling Peptides and ProteinsIntracranial Arteriovenous MalformationsMaleMiddle AgedMutationReceptors, Cell SurfaceSmad4 ProteinTelangiectasia, Hereditary HemorrhagicYoung AdultConceptsBrain arteriovenous malformationsHereditary hemorrhagic telangiectasiaHistory of ICHIntracranial hemorrhageArteriovenous malformationsMean ageVascular malformationsHemorrhagic telangiectasiaMultiple brain arteriovenous malformationsAutosomal dominant genetic diseaseDominant genetic diseaseGenetic test resultsAVM characteristicsClinical manifestationsAVM diagnosisPatientsInitial examinationMultiple organsLarger studyACVRL1 mutationsENG mutationsMalformationsAgeSignificant differencesManifestationsThe Young's Procedure for Severe Epistaxis from Hereditary Hemorrhagic Telangiectasia
Richer SL, Geisthoff UW, Livada N, Ward PD, Johnson L, Mainka A, Henderson KJ, Maune S, White RI, Ross DA. The Young's Procedure for Severe Epistaxis from Hereditary Hemorrhagic Telangiectasia. American Journal Of Rhinology And Allergy 2012, 26: 401-404. PMID: 23168156, DOI: 10.2500/ajra.2012.26.3809.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaSevere epistaxisYoung's procedureHemorrhagic telangiectasiaGlasgow Benefit Inventory scoreTransfusion-dependent patientsComplete cessationHHT CenterMost patientsSurgical treatmentPostoperative epistaxisSurgical closurePatient outcomesEfficacious procedureSubjective outcomesEpistaxisPatientsMean increaseSevere ironInventory scoresLaser proceduresCessationOutcomesTreatmentTelangiectasia
2011
Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia
Li W, Niu B, Henderson K, Northrup V, Pollak JS, Trow T, Fahey J, White RI. Reproducibility of Oxygen Saturation Monitoring During Six-Minute Walk Test and Exercise Stress Test in Patients with Pulmonary Arteriovenous Malformations Associated With Hereditary Hemorrhagic Telangiectasia. Pediatric Cardiology 2011, 32: 590-594. PMID: 21336824, DOI: 10.1007/s00246-011-9917-8.Peer-Reviewed Original ResearchConceptsPulmonary arteriovenous malformationsHereditary hemorrhagic telangiectasiaOxygen saturationHeart rateWalk testArteriovenous malformationsHemorrhagic telangiectasiaSix-minute walk testOxygen saturation monitoringLowest oxygen saturationYears of ageHuman Investigation CommitteeStress testIntraclass correlation coefficientAnatomic subtypesExercise capacityMultiple complicationsPatientsAdjunct testSaturation monitoringAdequate restReproducible measureMalformationsTelangiectasiaBroad spectrum
2008
Hormonal Therapy for the Treatment of Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia
Proctor DD, Henderson KJ, Dziura JD, White RI. Hormonal Therapy for the Treatment of Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia. Journal Of Clinical Gastroenterology 2008, 42: 756-757. PMID: 18496387, DOI: 10.1097/mcg.0b013e318032391f.Peer-Reviewed Original ResearchLong‐term complications of septal dermoplasty in patients with hereditary hemorrhagic telangiectasia
Levine CG, Ross DA, Henderson KJ, Leder SB, White RI. Long‐term complications of septal dermoplasty in patients with hereditary hemorrhagic telangiectasia. Otolaryngology 2008, 138: 721-724. PMID: 18503842, DOI: 10.1016/j.otohns.2008.01.005.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaSeptal dermoplastyQuality of lifeHemorrhagic telangiectasiaConsecutive retrospective studyLong-term complicationsLife-threatening epistaxisTreatment of choiceNasal odorConsecutive patientsSinus infectionRetrospective studySense of smellDermoplastyPatientsEpistaxisPotential patientsComplicationsPhone interviewsImproved qualityTelangiectasiaInfection
2007
Septectomy and Septal Dermoplasty for the Treatment of Severe Transfusion-Dependent Epistaxis in Patients with Hereditary Hemorrhagic Telangiectasia and Septal Perforation
Lesnik GT, Ross DA, Henderson KJ, Joe JK, Leder SB, White RI. Septectomy and Septal Dermoplasty for the Treatment of Severe Transfusion-Dependent Epistaxis in Patients with Hereditary Hemorrhagic Telangiectasia and Septal Perforation. American Journal Of Rhinology And Allergy 2007, 21: 312-315. PMID: 17621815, DOI: 10.2500/ajr.2007.21.3017.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaSeptal dermoplastySeptal perforationQuality of lifeTransfusion requirementsHHT patientsHemorrhagic telangiectasiaMainstay of treatmentCentral nervous systemAutosomal dominant disorderMonopolar cauterizationGraft uptakeCommon manifestationMucocutaneous tissuesSubjective improvementEffective treatmentEpistaxisVisceral organsPatientsSeptectomyNervous systemAbnormal angiogenesisPatient resultsTelangiectasia formationCombined procedure
2006
Clinical and Anatomic Outcomes after Embolotherapy of Pulmonary Arteriovenous Malformations
Pollak JS, Saluja S, Thabet A, Henderson KJ, Denbow N, White RI. Clinical and Anatomic Outcomes after Embolotherapy of Pulmonary Arteriovenous Malformations. Journal Of Vascular And Interventional Radiology 2006, 17: 35-45. PMID: 16415131, DOI: 10.1097/01.rvi.0000191410.13974.b6.Peer-Reviewed Original ResearchConceptsPulmonary AVMsResidual lesionsCollateral vesselsPulmonary arteriovenous malformation (PAVM) embolizationBronchial collateral vesselsPulmonary collateral vesselsOnset of symptomsPulmonary arteriovenous malformationsArteriovenous malformation embolizationHereditary hemorrhagic telangiectasiaHelical computed tomographyUnderwent embolizationAnatomic outcomesAsymptomatic eventsCerebral ischemiaRespiratory manifestationsAnatomic evaluationPhysiologic evaluationSymptomatic eventsArteriovenous malformationsAVM embolizationClinical assessmentHemorrhagic telangiectasiaComputed tomographyPatients
2005
Outcome of Septal Dermoplasty in Patients With Hereditary Hemorrhagic Telangiectasia
Fiorella ML, Ross D, Henderson KJ, White RI. Outcome of Septal Dermoplasty in Patients With Hereditary Hemorrhagic Telangiectasia. The Laryngoscope 2005, 115: 301-305. PMID: 15689755, DOI: 10.1097/01.mlg.0000154754.39797.43.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaSeptal dermoplastySymptomatic liver diseaseCerebral arteriovenous malformationsHemorrhagic telangiectasiaArteriovenous malformationsLiver diseaseGastrointestinal tract bleedingPulmonary arteriovenous malformationsLife-threatening epistaxisTreatment of choiceQuality of lifeUnits 1 yearTract bleedingTransfusion requirementsOrgan involvementUnrelated causesConsecutive patientsSevere epistaxisRetrospective studySecond therapyMean ageGastrointestinal tractDermoplastyPatientsEnteroscopic Evaluation of the Gastrointestinal Tract in Symptomatic Patients With Hereditary Hemorrhagic Telangiectasia
Proctor DD, Henderson KJ, Dziura JD, Longacre AV, White RI. Enteroscopic Evaluation of the Gastrointestinal Tract in Symptomatic Patients With Hereditary Hemorrhagic Telangiectasia. Journal Of Clinical Gastroenterology 2005, 39: 115-119. PMID: 15681905, DOI: 10.1097/01.mcg.0000150193.15978.f9.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaStomach/duodenumHemorrhagic telangiectasiaGastrointestinal bleedingNumber of telangiectasesSymptomatic adult patientsCross-sectional studyAutosomal dominant diseaseDistal stomachSymptomatic patientsAdult patientsMedian numberIndividual patientsGastrointestinal tractPatientsTelangiectasesDuodenumJejunal onesJejunumLarger telangiectasesStomachDominant diseaseBleedingAnemiaTelangiectasia
2003
Diagnosis and Management of Gastrointestinal Bleeding in Patients With Hereditary Hemorrhagic Telangiectasia
Longacre AV, Gross CP, Proctor D, Henderson KJ, Gallitelli M, White R. Diagnosis and Management of Gastrointestinal Bleeding in Patients With Hereditary Hemorrhagic Telangiectasia. The American Journal Of Gastroenterology 2003, 98: 59. PMID: 12526937, DOI: 10.1111/j.1572-0241.2003.07185.x.Peer-Reviewed Original ResearchConceptsBlood transfusion requirementsHereditary hemorrhagic telangiectasiaTransfusion requirementsGI bleedingMean HbDrug therapyHHT patientsHemorrhagic telangiectasiaEthinyl estradiol/norethindroneHigher blood transfusion requirementsIndividual patient basisLower mean HbGastrointestinal bleedingMean followRed blood cellsConsecutive patientsEndoscopic treatmentSignificant bleedingMean ageClinical evaluationBleedingPatient basisPatientsOptimal managementAminocaproic acid
2000
Liver Disease in Patients with Hereditary Hemorrhagic Telangiectasia
Garcia-Tsao G, Korzenik J, Young L, Henderson K, Jain D, Byrd B, Pollak J, White R. Liver Disease in Patients with Hereditary Hemorrhagic Telangiectasia. New England Journal Of Medicine 2000, 343: 931-936. PMID: 11006369, DOI: 10.1056/nejm200009283431305.Peer-Reviewed Original ResearchConceptsHereditary hemorrhagic telangiectasiaHigh-output heart failureHemorrhagic telangiectasiaHeart failureMedian periodPortal hypertensionLiver involvementClinical findingsBiliary diseasePulmonary capillary wedge pressureElevated alkaline phosphatase levelsHepatic sinusoidal pressureSymptomatic liver involvementTypical clinical presentationAlkaline phosphatase levelsAutosomal dominant disorderHyperdynamic circulationAngiodysplastic lesionsCardiac indexLiver transplantationVariceal bleedingWedge pressureMedical therapyRendu-OslerClinical presentation