Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior
Ibrahim K, Eilbott JA, Ventola P, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 1031-1041. PMID: 30979647, PMCID: PMC7173634, DOI: 10.1016/j.bpsc.2019.01.009.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCallous-unemotional traitsAmygdala-vlPFC connectivityDisruptive behaviorAmygdala reactivityNeural mechanismsSpectrum disorderAmygdala-prefrontal functional connectivityEmotion perception taskFunctional magnetic resonance imagingVentrolateral prefrontal cortexUnderlying neural mechanismsDisruptive behavior disordersTask-specific changesRisk of aggressionEmotion dysregulationFearful facesCalm facesPerception taskFear processingAmygdala activityPsychophysiological interactionAmygdala connectivityExternalizing behaviorsAmygdala hyperactivity