2024
Association of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion
Vora A, Pereira L, Du C, Tan Z, Huang C, Friedman D, Wang Y, Faridi K, Lakkireddy D, Zimmerman S, Higgins A, Kapadia S, Curtis J, Freeman J. Association of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion. JACC Cardiovascular Interventions 2024 PMID: 39474982, DOI: 10.1016/j.jcin.2024.10.020.Peer-Reviewed Original ResearchPhysician certificationAppendage occlusionAdverse eventsPercutaneous left atrial appendage occlusionLong-term oral anticoagulationDischarged patientsMultivariate Cox proportional hazards regression analysisRate of procedural complicationsLeft atrial appendage occlusionCox proportional hazards regression analysisProportional hazards regression analysisRisk of adverse eventsHazards regression analysisIn-hospital deathOral anticoagulantsWatchman FLXNo significant differenceLAAO devicesProcedural complicationsStratify patientsIntracardiac echocardiographyAtrial fibrillationEligible patientsIdentified patientsMultivariable adjustmentRethinking Our Roots: The Ground-Up Approach to Heart Health & Planetary Sustainability
Saad A, Brandt E, Faridi K, Paster J, Sheth S, Freeman A, Ramirez V, Aggarwal M. Rethinking Our Roots: The Ground-Up Approach to Heart Health & Planetary Sustainability. The American Journal Of Medicine 2024 PMID: 39383927, DOI: 10.1016/j.amjmed.2024.09.028.Peer-Reviewed Original ResearchPlanetary healthCardiovascular diseasePromote planetary healthPoor dietary habitsModifiable risk factorsNutrition educationChronic illnessDietary habitsFood insecurityRisk factorsHealthPlant-forward dietsTreat cardiovascular diseasesUnited StatesFood systemsAgricultural practicesDiseasePracticeComplex issuesIllnessNutritionHabitsEducationTCT-306 Association of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion
Vora A, Pereira L, Du C, Huang C, Friedman D, Wang Y, Zimmerman S, Faridi K, Higgins A, Kapadia S, Curtis J, Freeman J. TCT-306 Association of Physician Certification and Outcomes Among Patients Undergoing Left Atrial Appendage Occlusion. Journal Of The American College Of Cardiology 2024, 84: b71. DOI: 10.1016/j.jacc.2024.09.360.Peer-Reviewed Original ResearchProposed Mechanisms and Associations of COVID-19 with Cardiometabolic Risk Factors
Reddy K, Faridi K, Aggarwal M, Tirumalai A, Singh T, Tejtel K, Williams K, Litwin S, Dastmalchi L, White B, Barnard N, Ornish D, Batts T, Ajene G, Aspry K, Kris Etherton P, Hull S, Freeman A. Proposed Mechanisms and Associations of COVID-19 with Cardiometabolic Risk Factors. American Journal Of Lifestyle Medicine 2024 DOI: 10.1177/15598276241269532.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCardiometabolic riskLifestyle choicesCardiovascular diseaseHealthy lifestyle choicesCardiometabolic risk factorsHealth promotionReduce disease burdenCode BlueCardiovascular healthDisease preventionCOVID-19 morbidityPoor nutritionDisease burdenCOVID-19Disease burden resultsPublic healthGlobal leading causeLeading causeRisk factorsAssociation of COVID-19HealthLifestyleBurden resultsNutritionCardiovascular medicineContemporary Patterns of Medicare and Medicaid Utilization and Associated Spending on Tafamidis in Cardiac Amyloidosis
Bansal K, Majmundar V, Young G, Riello R, Faridi K, Ahmad T, Desai N. Contemporary Patterns of Medicare and Medicaid Utilization and Associated Spending on Tafamidis in Cardiac Amyloidosis. JACC Heart Failure 2024, 12: 1791-1793. PMID: 39115517, DOI: 10.1016/j.jchf.2024.07.002.Peer-Reviewed Original ResearchProcedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion
Friedman D, Du C, Zimmerman S, Tan Z, Lin Z, Vemulapalli S, Kosinski A, Piccini J, Pereira L, Minges K, Faridi K, Masoudi F, Curtis J, Freeman J. Procedure Volume and Outcomes With WATCHMAN Left Atrial Appendage Occlusion. Circulation Cardiovascular Interventions 2024, 17: e013466. PMID: 38889251, PMCID: PMC11189610, DOI: 10.1161/circinterventions.123.013466.Peer-Reviewed Original ResearchConceptsVolume-outcome relationshipLikelihood of procedural successLeft atrial appendage occlusionProcedural successProcedure volumeAppendage occlusionNational Cardiovascular Data Registry LAAO RegistryVolume quartilesLeft atrial appendage occlusion devicesThree-level hierarchical generalized linear modelsMinimum volume thresholdsWatchman FLX deviceProcedural success rateHierarchical generalized linear modelsAssociated with outcomePhysician volumeWATCHMAN procedureFLX deviceOcclusion deviceVolume thresholdCardiovascular proceduresPhysiciansHospitalNational analysisSuccess rateSerum Lipoproteins Are Associated With Coronary Atherosclerosis in Asymptomatic U.S. Adults Without Traditional Risk Factors
Faridi K, Lahan S, Budoff M, Cury R, Feldman T, Pan A, Fialkow J, Nasir K. Serum Lipoproteins Are Associated With Coronary Atherosclerosis in Asymptomatic U.S. Adults Without Traditional Risk Factors. JACC Advances 2024, 3: 101049. PMID: 39129991, PMCID: PMC11312344, DOI: 10.1016/j.jacadv.2024.101049.Peer-Reviewed Original ResearchTraditional risk factorsNon-HDL-CLDL-CRisk factorsAssociated with atherosclerosisCoronary atherosclerosisLipoprotein cholesterolAtherosclerotic cardiovascular disease riskSerum non-HDL-COptimal risk factorsLow-risk adultsActive tobacco useCardiovascular disease riskAssociation of low-density lipoprotein cholesterolAsymptomatic middle-aged adultsNon-high-density lipoprotein cholesterolAtherosclerosis prevalenceCoronary computed tomography angiographyHigh-risk plaque featuresMiddle-aged adultsAtherogenic lipoproteinsHigh LDL-CLow-density lipoprotein cholesterolLevels of atherogenic lipoproteinsMultivariate logistic regressionHigh- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT?
See C, Kim Y, Park J, Wang Y, Reinhardt S, Shkolnik E, Faridi K, Lombo B, Bellumkonda L, McNamara R, Sugeng L, Hur D. High- versus low-gradient aortic stenosis: Is our evaluation limited by aorto-mitral angle on cardiovascular CT? International Journal Of Cardiology 2024, 409: 132174. PMID: 38754590, DOI: 10.1016/j.ijcard.2024.132174.Peer-Reviewed Original ResearchNormal-flow low-gradientAortic valve areaTranscatheter AV replacementParadoxical low-flow low-gradientCardiovascular CTTransthoracic echocardiogramCalcium scoreAS patientsDiagnosis of severe ASLow-gradient aortic stenosisHG-AS patientsLG-AS patientsLow-flow low-gradientAorto-mitral angleAortic valve (AV) stenosisLG-ASPLFLG-ASAV replacementSevere ASConsecutive patientsAortic stenosisValve areaAS phenotypeClinical managementEchocardiogramUtilization of Fixed-Dose Combination Treatment for Hypertension in Medicare and Medicaid From 2016 to 2020
Essa M, Ross J, Dhruva S, Desai N, Spatz E, Faridi K. Utilization of Fixed-Dose Combination Treatment for Hypertension in Medicare and Medicaid From 2016 to 2020. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010697. PMID: 38712553, DOI: 10.1161/circoutcomes.123.010697.Peer-Reviewed Original ResearchMedicare Coverage and Patient Out-of-Pocket Costs for Cardiovascular-Kidney-Metabolic Medications
Young G, Bansal K, Riello R, Clark K, Dhruva S, Faridi K, Desai N. Medicare Coverage and Patient Out-of-Pocket Costs for Cardiovascular-Kidney-Metabolic Medications. JAMA Network Open 2024, 7: e2412437. PMID: 38771578, PMCID: PMC11109768, DOI: 10.1001/jamanetworkopen.2024.12437.Peer-Reviewed Original ResearchPragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID): A Randomized Clinical Trial
Shah N, Ghazi L, Yamamoto Y, Kumar S, Martin M, Simonov M, Riello Iii R, Faridi K, Ahmad T, Wilson F, Desai N. Pragmatic Trial of Messaging to Providers About Treatment of Hyperlipidemia (PROMPT-LIPID): A Randomized Clinical Trial. Circulation Cardiovascular Quality And Outcomes 2024, 17: e010335. PMID: 38634282, DOI: 10.1161/circoutcomes.123.010335.Peer-Reviewed Original ResearchElectronic health recordsElectronic health record alertsHigh-risk atherosclerotic cardiovascular diseaseLipid lowering therapyAtherosclerotic cardiovascular diseasePragmatic trialCardiovascular diseaseProportion of patientsYale New Haven HealthLDL-CSecondary outcomesPrimary outcomeInternal medicine cliniciansEHR alertUsual careHealth recordsProvider levelCluster-randomizedLDL-C managementLDL-C levelsAdverse cardiovascular eventsRandomized clinical trialsTreatment of hyperlipidemiaCliniciansCardiovascular eventsPredicting Major Adverse Events in Patients Undergoing Transcatheter Left Atrial Appendage Occlusion
Faridi K, Ong E, Zimmerman S, Varosy P, Friedman D, Hsu J, Kusumoto F, Mortazavi B, Minges K, Pereira L, Lakkireddy D, Koutras C, Denton B, Mobayed J, Curtis J, Freeman J. Predicting Major Adverse Events in Patients Undergoing Transcatheter Left Atrial Appendage Occlusion. Circulation Arrhythmia And Electrophysiology 2024, 17: e012424. PMID: 38390713, PMCID: PMC11021146, DOI: 10.1161/circep.123.012424.Peer-Reviewed Original ResearchNational Cardiovascular Data RegistryLeft atrial appendage occlusionIn-hospital major adverse eventsMajor adverse eventsBedside risk scoreRisk scoreData RegistryIncreased fall riskAdverse eventsQuality improvement effortsWatchman FLXAppendage occlusionFall riskLeft atrial appendage occlusion procedureRegistry dataImprovement effortsRisk of in-hospital major adverse eventsPredicting major adverse eventsLogistic regressionAdverse event ratesModerate discriminationClinically relevant variablesFemale sexAtrial fibrillation terminationLAAO proceduresFactors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice
Faridi K, Zhu Z, Shah N, Crandall I, McNamara R, Flueckiger P, Bachand K, Lombo B, Hur D, Agarwal V, Reinhardt S, Velazquez E, Sugeng L. Factors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice. Echocardiography 2024, 41: e15774. PMID: 38329886, DOI: 10.1111/echo.15774.Peer-Reviewed Original ResearchConceptsTransthoracic echocardiogramVentricular ejection fractionOutpatient transthoracic echocardiogramsReal-world practiceEjection fractionLeft ventricular ejection fractionAssess left ventricular ejection fractionInpatient transthoracic echocardiogramsMultivariate logistic regressionLVEFHospitalized patientsMedical CenterSonographersClinical settingLogistic regressionUltrasound machineChemotherapyContrast enhancement agentsPortable studiesNegative association
2023
Variation in Reader-Reported Severity of Paradoxical Low-Flow Low-Gradient Aortic Stenosis
Shah N, Sugeng L, Zhang Z, Wang K, McNamara R, Agarwal V, Hur D, Lombo B, Bellumkonda L, Mankbadi M, Basem Dajani A, Forrest J, Krumholz H, Reinhardt S, Velazquez E, Faridi K. Variation in Reader-Reported Severity of Paradoxical Low-Flow Low-Gradient Aortic Stenosis. Journal Of The American Society Of Echocardiography 2023, 37: 466-467. PMID: 37995937, DOI: 10.1016/j.echo.2023.11.014.Peer-Reviewed Original ResearchCase report: Coronary atherosclerosis in a patient with long-standing very low LDL-C without lipid-lowering therapy
Mottola G, Welty F, Mojibian H, Faridi K. Case report: Coronary atherosclerosis in a patient with long-standing very low LDL-C without lipid-lowering therapy. Frontiers In Cardiovascular Medicine 2023, 10: 1272944. PMID: 37795488, PMCID: PMC10546007, DOI: 10.3389/fcvm.2023.1272944.Peer-Reviewed Case Reports and Technical NotesLipid-lowering therapyLDL-C levelsCoronary atherosclerosisLow LDL-C levelsLow-density lipoprotein cholesterolCardiovascular risk factorsLeft coronary systemRight coronary arteryLow serum levelsDevelopment of atherosclerosisNonobstructive coronary atherosclerosisRoutine laboratory dataTomography angiography scansApoB-containing lipoproteinsHeterozygous familial hypobetalipoproteinemiaAnomalous originMyxoma resectionAcute strokeAtrial myxomaCardiovascular riskLipoprotein cholesterolPlaque regressionDiabetes mellitusPrimordial preventionSerum levelsSevere aortic stenosis detection by deep learning applied to echocardiography
Holste G, Oikonomou E, Mortazavi B, Coppi A, Faridi K, Miller E, Forrest J, McNamara R, Ohno-Machado L, Yuan N, Gupta A, Ouyang D, Krumholz H, Wang Z, Khera R. Severe aortic stenosis detection by deep learning applied to echocardiography. European Heart Journal 2023, 44: 4592-4604. PMID: 37611002, PMCID: PMC11004929, DOI: 10.1093/eurheartj/ehad456.Peer-Reviewed Original ResearchAssociation Between Claims‐Defined Frailty and Outcomes Following 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: Findings From the EXTEND‐DAPT Study
Faridi K, Strom J, Kundi H, Butala N, Curtis J, Gao Q, Song Y, Zheng L, Tamez H, Shen C, Secemsky E, Yeh R. Association Between Claims‐Defined Frailty and Outcomes Following 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: Findings From the EXTEND‐DAPT Study. Journal Of The American Heart Association 2023, 12: e029588. PMID: 37449567, PMCID: PMC10382113, DOI: 10.1161/jaha.123.029588.Peer-Reviewed Original ResearchConceptsExtended duration dual antiplatelet therapyDuration dual antiplatelet therapyNet adverse clinical eventsDual antiplatelet therapyAdverse clinical eventsPercutaneous coronary interventionCoronary interventionClinical eventsNonfrail patientsAntiplatelet therapyFrail patientsClaims dataMonths of DAPTClaims-based indexYears of ageMajor bleedingCause mortalityMultivariable adjustmentOlder patientsDAPT studyResults PatientsBackground FrailtyMyocardial infarctionClinical trialsMedicare claimsImpact of Preprocedure Imaging for Left Atrial Appendage Occlusion Insights From the NCDR LAAO Registry
Clarke J, Higgins A, Wang Y, Faridi K, Curtis J, Freeman J, Friedman D. Impact of Preprocedure Imaging for Left Atrial Appendage Occlusion Insights From the NCDR LAAO Registry. JACC Cardiovascular Interventions 2023, 16: 1317-1328. PMID: 37316143, DOI: 10.1016/j.jcin.2023.05.008.Peer-Reviewed Original ResearchConceptsDevice successImplantation successPreprocedure imagingProcedure successLAAO proceduresAbnormal renal functionAtrial appendage occlusionMultivariable logistic regressionOutcomes of interestMagnitude of benefitLAAO implantationPrior thromboembolismUncontrolled hypertensionRate of useRenal functionAppendage occlusionProcedural successUniversity HospitalLogistic regressionCMR useOverall rateCMRPatientsPreprocedureRegistryWatchman device migration and embolization: A report from the NCDR LAAO Registry
Friedman D, Freeman J, Zimmerman S, Tan Z, Pereira L, Faridi K, Curtis J. Watchman device migration and embolization: A report from the NCDR LAAO Registry. Journal Of Cardiovascular Electrophysiology 2023, 34: 1192-1195. PMID: 37078339, PMCID: PMC10290479, DOI: 10.1111/jce.15909.Peer-Reviewed Original ResearchConceptsWATCHMAN procedureSurgical retrievalDevice migrationMortality rateAtrial appendage closure deviceHospital mortality rateAnnual procedure volumeCardiac surgeryHospital eventsPostdischarge eventsOstial sizeDevice embolizationTaller patientsRetrospective analysisClosure deviceLAA ostiumPatientsProcedure volumeHigh mortalitySurgerySubstantial proportionEmbolizationRegistryGreater body massBody massTrends in Spending and Claims for P2Y12 Inhibitors by Medicare and Medicaid From 2015 to 2020
Essa M, Ross J, Dhruva S, Desai N, Yeh R, Faridi K. Trends in Spending and Claims for P2Y12 Inhibitors by Medicare and Medicaid From 2015 to 2020. Journal Of The American Heart Association 2023, 12: e028869. PMID: 37042289, PMCID: PMC10227267, DOI: 10.1161/jaha.122.028869.Peer-Reviewed Original Research