F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis
Belsky JB, Filbin MR, Rivers EP, Bobbitt KR, Jaehne AK, Wisnik CA, Maciejewski KR, Li F, Morris DC. F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis. Biomarkers 2020, 25: 391-396. PMID: 32421363, DOI: 10.1080/1354750x.2020.1771419.Peer-Reviewed Original ResearchConceptsIntensive care unitEmergency departmentQSOFA scoreIllness severityPlasma levelsThymosin beta 4Quick Sequential Organ Failure Assessment (qSOFA) scoreSequential Organ Failure Assessment scoreIntensive care unit admissionOrgan Failure Assessment scoreCare unit admissionPositive urine cultureSymptoms of sepsisSystemic inflammatory syndromeDiagnosis of sepsisEmergency department patientsSignificant outcome measureBeta 4Unit admissionICU admissionInflammatory syndromeDepartment patientsSeptic shockCare unitED patientsThymosin beta 4 regulation of actin in sepsis
Belsky JB, Rivers EP, Filbin MR, Lee PJ, Morris DC. Thymosin beta 4 regulation of actin in sepsis. Expert Opinion On Biological Therapy 2018, 18: 193-197. PMID: 29508629, PMCID: PMC6556887, DOI: 10.1080/14712598.2018.1448381.Peer-Reviewed Original ResearchConceptsThymosin beta 4Beta 4Life-threatening organ damageAnti-inflammatory genesAnti-inflammatory propertiesComprehensive literature searchMicrocirculatory perturbationsInflammatory mediatorsOrgan damageSepsis resultsSeptic ratsClinical trialsSepsisAnti-oxidative enzymesHost responseLiterature searchAnti-apoptotic enzymesReactive oxygen speciesDecreased concentrationMeasurable levelsMortalityCurrent knowledgeOxygen speciesBinding proteinPatientsPlasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock
Belsky JB, Morris DC, Bouchebl R, Filbin MR, Bobbitt KR, Jaehne AK, Rivers EP. Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock. Biomarkers 2016, 21: 180-185. PMID: 26754286, DOI: 10.3109/1354750x.2015.1126646.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeNoninfectious systemic inflammatory response syndromeSeptic shockThymosin beta 4Healthy controlsSIRS groupPlasma levelsInflammatory response syndromePotential new biomarkersResponse syndromeActin ratioNew biomarkersPotential biomarkersBeta 4PatientsBiomarkersActin levelsF-actinGroupSyndromeLevelsDiagnosis