Featured Publications
Sepsis Fluid Metric Compliance and its Impact on Outcomes of Patients with Congestive Heart Failure, End-Stage Renal Disease or Obesity
Boccio E, Haimovich A, Jacob V, Maciejewski KR, Wira CR, Belsky J. Sepsis Fluid Metric Compliance and its Impact on Outcomes of Patients with Congestive Heart Failure, End-Stage Renal Disease or Obesity. Journal Of Emergency Medicine 2021, 61: 466-480. PMID: 34088547, DOI: 10.1016/j.jemermed.2021.03.004.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseCongestive heart failurePre-existing congestive heart failurePre-existing conditionsMultiple pre-existing conditionsShock patientsHeart failureRenal diseaseEmergency departmentED patient encountersOutcomes of patientsRetrospective chart reviewSeptic shock patientsFluid overload statesLength of stayUrban academic centerFluid goalChart reviewSeptic shockFluid administrationFluid bolusEmergency physiciansObesityPatientsAcademic centersEffect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis
Sevransky J, Rothman R, Hager D, Bernard G, Brown S, Buchman T, Busse L, Coopersmith C, DeWilde C, Ely E, Eyzaguirre L, Fowler A, Gaieski D, Gong M, Hall A, Hinson J, Hooper M, Kelen G, Khan A, Levine M, Lewis R, Lindsell C, Marlin J, McGlothlin A, Moore B, Nugent K, Nwosu S, Polito C, Rice T, Ricketts E, Rudolph C, Sanfilippo F, Viele K, Martin G, Wright D, Nugent K, Spainhour C, Polito C, Moore B, Negrin L, Khan A, Kea B, Krol O, Haq E, Pinkert V, Nguyen K, Brown S, Bledsoe J, Peltan I, Applegate D, Armbruster B, Montgomery Q, Brown K, Daw A, Gong M, Aboodi M, Chen J, Hope A, Gummadi S, Lopez B, Hinson J, Hager D, Ricketts E, Clements C, Gajic O, Kashyap R, Vanmeter D, Busse L, McBride M, Ginde A, Moss M, Finck L, Howell M, McKeehan J, Higgins C, Clare J, McBryde B, Barksdale A, Kalin D, Kruse D, Hilz K, Qadir N, Chang S, Beutler R, Tam A, Harris E, Youngquist S, Middleton E, Davidov E, Plante A, Belsky J, Siner J, Wira C, Brokowski C, Steingrub J, Smithline H, Thornton-Thompson S, Fowler A, Miller S, Narron K, Puskarich M, Prekker M, Hendrickson A, Quinn J, Wilson J, Levitt J, Mann R, Visweswaran A, Gentile N, Marchetti N, Reimer H, Guirgis F, Jones L, Black L, Henson M, Meyer N, Greenwood J, Ittner C, Rivers E, Jayaprakash N, Gardner-Gray J, Hurst G, Pflaum J, Jaehne A, Gill J, Cook A, Janz D, Vonderhaar D, Romaine C, Wilkerson R, McCurdy M, Beach D, Lasko K, Gill R, Price K, Dickson L, Duggal A, Mace S, Hite R, Hastings A, Haukoos J, Douglas I, Trent S, Lyle C, Cupelo A, Gravitz S, Hiller T, Oakes J, LoVecchio F, Quiroga P, Danley S, Mulrow M, Encinas A, Goodwin A, Hall G, Grady A, Exline M, Terndrup T, Pannu S, Robart E, Karow S, Files D, Smith L, Gibbs K, Flores L, Pastores S, Shaz D, Kostelecky N, Case C, Wilkins E, Gaieski D, Baram M, Schwegler D, Renzi N, Mosier J, Hypes C, Campbell E, Hooper M, Sill J, Mitchell K, Hudock K, Lyons M, Gorder K, Ahmad Y, Studer A, Davis J, Barrett M, Nomura J, Knox J, Park P, Co I, McSparron J, Hyzy R, McDonough K, Hanna S, Self W, Semler M, Hays M, Bartz R, Limkakeng A, Sweeney K, Woodburn R, Goyal M, Zaaqoq A, Moriarty T, Oropello J, Zhang Z. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis. JAMA 2021, 325: 742-750. PMID: 33620405, PMCID: PMC7903252, DOI: 10.1001/jama.2020.24505.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnti-Inflammatory AgentsAscorbic AcidCritical IllnessDouble-Blind MethodDrug Therapy, CombinationEarly Termination of Clinical TrialsFemaleHumansHydrocortisoneLength of StayMaleMiddle AgedOrgan Dysfunction ScoresRespiration, ArtificialRespiratory InsufficiencySepsisThiamineTreatment OutcomeVasoconstrictor AgentsVitaminsConceptsVasopressor-free daysIntensive care unitVitamin CPlacebo groupCare unitIntervention groupDays of randomizationIntravenous vitamin CPlacebo-controlled trialThirty-day mortalityTotal daily doseKey secondary outcomesAdult patientsSecondary outcomesDaily doseIll patientsPrimary outcomeSubstantial morbidityCardiovascular dysfunctionEmergency departmentCommon syndromeMAIN OUTCOMESepsisPlaceboPatientsF-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis
Belsky JB, Filbin MR, Rivers EP, Bobbitt KR, Jaehne AK, Wisnik CA, Maciejewski KR, Li F, Morris DC. F-Actin is associated with a worsening qSOFA score and intensive care unit admission in emergency department patients at risk for sepsis. Biomarkers 2020, 25: 391-396. PMID: 32421363, DOI: 10.1080/1354750x.2020.1771419.Peer-Reviewed Original ResearchConceptsIntensive care unitEmergency departmentQSOFA scoreIllness severityPlasma levelsThymosin beta 4Quick Sequential Organ Failure Assessment (qSOFA) scoreSequential Organ Failure Assessment scoreIntensive care unit admissionOrgan Failure Assessment scoreCare unit admissionPositive urine cultureSymptoms of sepsisSystemic inflammatory syndromeDiagnosis of sepsisEmergency department patientsSignificant outcome measureBeta 4Unit admissionICU admissionInflammatory syndromeDepartment patientsSeptic shockCare unitED patientsEarly goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE
Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, Tatem G, Salem D, Moore S, Boka K, Gill JK, Gardner-Gray J, Pflaum J, Domecq JP, Hurst G, Belsky JB, Fowkes R, Elkin RB, Simpson SQ, Falk JL, Singer DJ, Rivers EP. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Critical Care 2016, 20: 160. PMID: 27364620, PMCID: PMC4929762, DOI: 10.1186/s13054-016-1288-3.Peer-Reviewed Original ResearchConceptsEarly goal-directed therapyGoal-directed therapySeptic shockSevere sepsisSepsis mortalitySepsis managementSignificant mortality reductionSurviving Sepsis CampaignAcute myocardial infarctionStandard of careEarly sepsis managementHemodynamic pathogenesisUsual careSepsis CampaignStandard careEmergency departmentMyocardial infarctionEarly managementOutcome benefitsClinical trialsMortality reductionTherapyMortalityTrialsCare
2024
End-tidal oxygen as an effective non-invasive measure of preoxygenation during rapid sequence intubation in the emergency department
Boccio E, Belsky J, Lopez S, Kohen B, Bonz J. End-tidal oxygen as an effective non-invasive measure of preoxygenation during rapid sequence intubation in the emergency department. Journal Of Emergency Medicine 2024 DOI: 10.1016/j.jemermed.2024.07.006.Peer-Reviewed Original ResearchEmergency departmentConvenience sample of patientsEnd-tidal oxygenDuration of apneaAssociated with likelihoodProspective observational studyBody mass indexPeripheral capillary oxygen saturationConvenience sampleSample of patientsCapillary oxygen saturationOptimal preoxygenationPatient ageSecondary aimDesaturation eventsMass indexPatient characteristicsIntubation attemptsPreoxygenationObservational studyOxygen saturationSpO2 levelsPatientsIntubationSpO2
2020
A Research Protocol and Case Report of Emergency Department Endovascular Aortic Occlusion (REBOA) in Non-traumatic Cardiac Arrest
Daley J, Cannon K, Buckley R, Aydin A, Latich I, Lozada J, Bonz J, Joseph D, Coughlin R, Belsky J, Van Tonder R, Sather J, Wira C, Liu R, Johnson A, Moore C. A Research Protocol and Case Report of Emergency Department Endovascular Aortic Occlusion (REBOA) in Non-traumatic Cardiac Arrest. Journal Of Endovascular Resuscitation And Trauma Management 2020, 4: 88-93. DOI: 10.26676/jevtm.v4i2.140.Peer-Reviewed Original ResearchAdvanced cardiac life supportCardiac life supportEmergency departmentEmergency physiciansAortic occlusionCardiac arrestCase reportNon-traumatic cardiac arrestLife supportResuscitative endovascular balloon occlusionResearch protocolFeasibility of REBOAFavorable neurologic outcomeMean arterial pressureNon-traumatic OHCAFemoral arterial accessEndovascular balloon occlusionHospital cardiac arrestTidal carbon dioxideEndovascular aortic occlusionEarly human studiesNeurologic outcomeSecondary outcomesArterial pressureInitial patients