2021
Improved performance and consistency of deep learning 3D liver segmentation with heterogeneous cancer stages in magnetic resonance imaging
Gross M, Spektor M, Jaffe A, Kucukkaya AS, Iseke S, Haider SP, Strazzabosco M, Chapiro J, Onofrey JA. Improved performance and consistency of deep learning 3D liver segmentation with heterogeneous cancer stages in magnetic resonance imaging. PLOS ONE 2021, 16: e0260630. PMID: 34852007, PMCID: PMC8635384, DOI: 10.1371/journal.pone.0260630.Peer-Reviewed Original ResearchAnatomy-guided multimodal registration by learning segmentation without ground truth: Application to intraprocedural CBCT/MR liver segmentation and registration
Zhou B, Augenfeld Z, Chapiro J, Zhou SK, Liu C, Duncan JS. Anatomy-guided multimodal registration by learning segmentation without ground truth: Application to intraprocedural CBCT/MR liver segmentation and registration. Medical Image Analysis 2021, 71: 102041. PMID: 33823397, PMCID: PMC8184611, DOI: 10.1016/j.media.2021.102041.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsCarcinoma, HepatocellularChemoembolization, TherapeuticCone-Beam Computed TomographyHumansImage Processing, Computer-AssistedLiver NeoplasmsSpiral Cone-Beam Computed TomographyConceptsMultimodal registrationLiver segmentationLarge-scale manual annotationGround truthMultimodal image registrationMultimodal registration methodSegmentation networkDomain adaptationManual annotationSource modalityImage registrationRegistration frameworkSegmentationImage-guided interventionsRegistration methodMedical imagingDiagnostic medical imagingCorrect transformationLimited FOVStructure informationIntraprocedural CBCTImage qualitySegmenterExperimental resultsPatient data
2020
Automated feature quantification of Lipiodol as imaging biomarker to predict therapeutic efficacy of conventional transarterial chemoembolization of liver cancer
Stark S, Wang C, Savic LJ, Letzen B, Schobert I, Miszczuk M, Murali N, Oestmann P, Gebauer B, Lin M, Duncan J, Schlachter T, Chapiro J. Automated feature quantification of Lipiodol as imaging biomarker to predict therapeutic efficacy of conventional transarterial chemoembolization of liver cancer. Scientific Reports 2020, 10: 18026. PMID: 33093524, PMCID: PMC7582153, DOI: 10.1038/s41598-020-75120-7.Peer-Reviewed Original ResearchConceptsConventional transarterial chemoembolizationLipiodol depositionTransarterial chemoembolizationLiver cancerPeripheral depositionLipiodol depositsTherapeutic efficacyNecrotic tumor areasBaseline MRITherapy optionsTumor responseTreatment responseTumor volumeLiver lesionsLipiodolH postTumor areaH-CTHounsfield unitsBiomarkersChemoembolizationHigh rateTumorsCancerImproved responseFibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation
Tefera J, Revzin M, Chapiro J, Savic L, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. Fibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation. Journal Of Clinical Pathology 2020, 74: 31-35. PMID: 32430483, PMCID: PMC7674234, DOI: 10.1136/jclinpath-2020-206574.Peer-Reviewed Original ResearchMeSH KeywordsAgedCarcinoma, HepatocellularCohort StudiesConnecticutDisease ProgressionFemaleHumansImage Processing, Computer-AssistedLiverLiver CirrhosisLiver NeoplasmsMaleMiddle AgedRadiographyRetrospective StudiesConceptsAdvanced Barcelona Clinic Liver Cancer stageBarcelona Clinic Liver Cancer stageScirrhous HCCMultiple rounded nodulesNon-peripheral washoutLiver Cancer stageRadiological featuresClinical featuresRadiological correlationCarcinoma variantsCancer stageHCC casesHepatocellular carcinomaLiver cancerFibrotic liverConventional HCCHCCLower ratesHigh rateRounded nodulesProgressionDistinct patternsCarcinomaSpecific variantsLesions
2019
Theranostic application of lipiodol for transarterial chemoembolization in a VX2 rabbit liver tumor model
van Breugel JMM, Geschwind JF, Mirpour S, Savic LJ, Zhang X, Duran R, Lin M, Miszczuk M, Liapi E, Chapiro J. Theranostic application of lipiodol for transarterial chemoembolization in a VX2 rabbit liver tumor model. Theranostics 2019, 9: 3674-3686. PMID: 31281506, PMCID: PMC6587357, DOI: 10.7150/thno.32943.Peer-Reviewed Original ResearchConceptsOil Red OPerfusion indexMicrovascular densityLipiodol depositionLiver cancerTherapeutic efficacyVX2 tumorsContrast-enhanced CT scanRabbit liver tumor modelTumor-specific functionsNon-tumoral liverLiver tumor modelRadiological-pathological correlationVX2 rabbit liver tumor modelPortal flowTransarterial chemoembolizationLeft lobeLipiodol retentionTherapeutic managementPatient responseTumor vascularityTumor volumeArterial flowCT scanTumor perfusion
2017
Characteristics of a New X-Ray Imaging System for Interventional Procedures: Improved Image Quality and Reduced Radiation Dose
Schernthaner RE, Haroun RR, Nguyen S, Duran R, Sohn JH, Sahu S, Chapiro J, Zhao Y, Radaelli A, van der Bom IM, Mauti M, Hong K, Geschwind JH, Lin M. Characteristics of a New X-Ray Imaging System for Interventional Procedures: Improved Image Quality and Reduced Radiation Dose. CardioVascular And Interventional Radiology 2017, 41: 502-508. PMID: 29090348, PMCID: PMC5801377, DOI: 10.1007/s00270-017-1821-z.Peer-Reviewed Original ResearchC-Arm Cone Beam CT for Intraprocedural Image Fusion and 3D Guidance in Portal Vein Embolization (PVE)
Lüdemann WM, Böning G, Chapiro J, Jonczyk M, Geisel D, Schnapauff D, Wieners G, Schmelzle M, Chopra S, Günther RW, Gebauer B, Streitparth F. C-Arm Cone Beam CT for Intraprocedural Image Fusion and 3D Guidance in Portal Vein Embolization (PVE). CardioVascular And Interventional Radiology 2017, 41: 424-432. PMID: 28875339, DOI: 10.1007/s00270-017-1782-2.Peer-Reviewed Original ResearchConceptsPortal vein embolizationDose area productVein embolizationPuncture timeControl groupNeedle guidanceDifficult anatomic situationsIntervention-related complicationsTotal dose-area productPortal vein anatomyC-arm cone beamPortal vein accessC-arm cone-beam CTUse of USNumber of puncturesContrast-enhanced CBCTFuture liverLiver diseaseTechnical successVein accessUltrasound guidanceCE-CTVein anatomyAnatomic situationPuncture attempts
2016
Intra-arterial therapies for liver cancer: assessing tumor response
Stroehl YW, Letzen BS, van Breugel JM, Geschwind JF, Chapiro J. Intra-arterial therapies for liver cancer: assessing tumor response. Expert Review Of Anticancer Therapy 2016, 17: 119-127. PMID: 27983883, DOI: 10.1080/14737140.2017.1273775.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorCarcinoma, HepatocellularChemoembolization, TherapeuticHumansImage Processing, Computer-AssistedImaging, Three-DimensionalInfusions, Intra-ArterialLiver NeoplasmsTreatment Outcome
2015
Three-Dimensional Quantitative Assessment of Lesion Response to MR-guided High-Intensity Focused Ultrasound Treatment of Uterine Fibroids
Savic LJ, De Lin M, Duran R, Schernthaner RE, Hamm B, Geschwind JF, Hong K, Chapiro J. Three-Dimensional Quantitative Assessment of Lesion Response to MR-guided High-Intensity Focused Ultrasound Treatment of Uterine Fibroids. Academic Radiology 2015, 22: 1199-1205. PMID: 26160057, PMCID: PMC4546360, DOI: 10.1016/j.acra.2015.05.008.Peer-Reviewed Original ResearchAdultCohort StudiesContrast MediaFeasibility StudiesFemaleFollow-Up StudiesHigh-Intensity Focused Ultrasound AblationHumansImage Processing, Computer-AssistedImaging, Three-DimensionalLeiomyomaMagnetic Resonance Imaging, InterventionalMiddle AgedRemission InductionRetrospective StudiesTreatment OutcomeTumor BurdenUterine NeoplasmsA new angiographic imaging platform reduces radiation exposure for patients with liver cancer treated with transarterial chemoembolization
Schernthaner RE, Duran R, Chapiro J, Wang Z, Geschwind JF, Lin M. A new angiographic imaging platform reduces radiation exposure for patients with liver cancer treated with transarterial chemoembolization. European Radiology 2015, 25: 3255-3262. PMID: 25956933, PMCID: PMC4595540, DOI: 10.1007/s00330-015-3717-0.Peer-Reviewed Original ResearchConceptsDose area productDigital subtraction angiographyTransarterial chemoembolizationCone-beam CTRadiation exposureLiver cancerDSA image qualityCumulative dose area productSecondary liver cancerLiver cancer patientsTwo-arm trialSignificant differencesResultsBoth cohortsDiagnostic image qualityPatient characteristicsConsecutive patientsTumor burdenTACE proceduresCancer patientsSubtraction angiographyPatientsHIPAA compliantDigital fluoroscopyProcedure courseIndependent readers