2014
Genetic alterations in chondrosarcomas – keys to targeted therapies?
Samuel AM, Costa J, Lindskog DM. Genetic alterations in chondrosarcomas – keys to targeted therapies? Cellular Oncology 2014, 37: 95-105. PMID: 24458248, DOI: 10.1007/s13402-014-0166-8.Peer-Reviewed Original ResearchConceptsBenign cartilaginous lesionsCartilaginous lesionsMalignant transformationIhh/PTHrPTwo-hit scenarioPrimary bone tumorsGenetic alterationsDruggable molecular targetsKey genetic alterationsHuman tumor typesResultsCurrent dataBone tumorsMalignant tumorsSarcoma typesMalignant chondrosarcomasKey molecular changesNormal cell cycle controlTumor typesMalignant cellsChondrosarcoma developmentLesionsMolecular targetsTumorsEarly-stage eventsDifferentiation of chondrocytes
1985
Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors
Knazek R, Yee C, Costa J. Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors. International Journal Of Cancer 1985, 36: 143-152. PMID: 2991146, DOI: 10.1002/ijc.2910360204.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArachidonic AcidArachidonic AcidsChondrosarcomaChromatography, High Pressure LiquidChromatography, Thin LayerHistiocytoma, Benign FibrousHumansHydroxyeicosatetraenoic AcidsMiceMice, NudeNeoplasm TransplantationProstaglandinsRadioimmunoassayRhabdomyosarcomaSarcomaSarcoma, SynovialSoft Tissue NeoplasmsTeratomaConceptsArachidonic acid metabolitesAcid metabolitesSynovial cell sarcomaSame histological typeMalignant fibrous histiocytomaTotal prostaglandin synthesisHydroxyeicosatetraenoic acid synthesisHuman mesenchymal tumorsMesenchymal tumor cellsHistological typeMesenchymal tumorsPGF2 alphaFibrous histiocytomaThromboxane A2Embryonal carcinomaNude miceProstaglandin synthesisPGE2 synthesisTransplantable tumorsAlveolar rhabdomyosarcomaTumorsStromal cellsArachidonic acidNormal tissuesTumor cells