Featured Publications
Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage
Zheng WL, Kim JA, Elmer J, Zafar SF, Ghanta M, Moura V, Patel A, Rosenthal E, Westover M. Automated EEG-based prediction of delayed cerebral ischemia after subarachnoid hemorrhage. Clinical Neurophysiology 2022, 143: 97-106. PMID: 36182752, PMCID: PMC9847346, DOI: 10.1016/j.clinph.2022.08.023.Peer-Reviewed Original ResearchConceptsMultiple EEG featuresEEG featuresInformative featuresPrediction algorithmSubarachnoid hemorrhageBetter performanceNon-DCI patientsMachineCerebral ischemiaDCI riskAlpha-delta ratioAneurysmal subarachnoid hemorrhageUtility of electroencephalographyReceiver operator curveFeaturesDCI predictionAlgorithmDCI onsetSAH patientsShannon entropyDay 5Whole brainAlpha variabilityPatientsPrediction
2021
Antiseizure Medication Treatment and Outcomes in Patients with Subarachnoid Hemorrhage Undergoing Continuous EEG Monitoring
Zafar SF, Rosenthal ES, Postma EN, Sanches P, Ayub MA, Rajan S, Kim JA, Rubin DB, Lee H, Patel AB, Hsu J, Patorno E, Westover MB. Antiseizure Medication Treatment and Outcomes in Patients with Subarachnoid Hemorrhage Undergoing Continuous EEG Monitoring. Neurocritical Care 2021, 36: 857-867. PMID: 34843082, PMCID: PMC9117405, DOI: 10.1007/s12028-021-01387-x.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageGood functional outcomeAntiseizure medicationsFunctional outcomeContinuous electroencephalographyEpileptiform activityLower likelihoodBetter outcomesAneurysm treatmentRetrospective single-center cohort studySingle-center cohort studyAntiseizure medication (ASM) treatmentElectroencephalographic epileptiform activityResultsNinety-four patientsDay of admissionContinuous EEG monitoringASM treatmentCEEG initiationCohort studyProspective trialHigh-intensity treatmentLow-intensity treatmentMedication treatmentSubarachnoid hemorrhageOutcome measures
2018
Effect of epileptiform abnormality burden on neurologic outcome and antiepileptic drug management after subarachnoid hemorrhage
Zafar SF, Postma EN, Biswal S, Boyle EJ, Bechek S, O'Connor K, Shenoy A, Kim J, Shafi MS, Patel AB, Rosenthal ES, Westover MB. Effect of epileptiform abnormality burden on neurologic outcome and antiepileptic drug management after subarachnoid hemorrhage. Clinical Neurophysiology 2018, 129: 2219-2227. PMID: 30212805, PMCID: PMC6478499, DOI: 10.1016/j.clinph.2018.08.015.Peer-Reviewed Original ResearchConceptsAnti-epileptic drugsAneurysmal subarachnoid hemorrhageEpileptiform abnormalitiesWorse outcomesSubarachnoid hemorrhageHigh-grade aSAH patientsEvidence-based treatment protocolsGlasgow Outcome ScoreAntiepileptic drug managementStandard prophylaxisNeurologic outcomeProphylactic protocolASAH patientsOutcome scoresDrug managementHigh burdenRetrospective analysisTreatment protocolOutcome measuresPatientsDaily burdenRhythmic activityFirst dayOutcomesBurden
2017
Electronic Health Data Predict Outcomes After Aneurysmal Subarachnoid Hemorrhage
Zafar SF, Postma EN, Biswal S, Fleuren L, Boyle EJ, Bechek S, O’Connor K, Shenoy A, Jonnalagadda D, Kim J, Shafi MS, Patel AB, Rosenthal ES, Westover MB. Electronic Health Data Predict Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2017, 28: 184-193. PMID: 28983801, PMCID: PMC5886829, DOI: 10.1007/s12028-017-0466-8.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageGlasgow Outcome ScaleWhite blood cellsIntracranial pressureAPACHE IIElectronic health dataSubarachnoid hemorrhageBetter outcomesSingle-center retrospective cohort studyDischarge Glasgow Outcome ScaleEarly goal-directed therapyAPACHE II scoreGoal-directed therapyRetrospective cohort studyMean arterial pressureRisk stratification scoresAdmission APACHE IIPredictors of outcomeMultivariate analysis predictorsLogistic regression modelsHealth dataAdmission dayII scoreNeurologic outcomeArterial pressure