Featured Publications
Development and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography Reports
Torres-Lopez VM, Rovenolt GE, Olcese AJ, Garcia GE, Chacko SM, Robinson A, Gaiser E, Acosta J, Herman AL, Kuohn LR, Leary M, Soto AL, Zhang Q, Fatima S, Falcone GJ, Payabvash MS, Sharma R, Struck AF, Sheth KN, Westover MB, Kim JA. Development and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography Reports. JAMA Network Open 2022, 5: e2227109. PMID: 35972739, PMCID: PMC9382443, DOI: 10.1001/jamanetworkopen.2022.27109.Peer-Reviewed Original ResearchConceptsNatural language processingF-scoreTest data setsLanguage processingIndependent test data setsData setsBidirectional Encoder RepresentationsAcute brain injuryLarge data setsHead CTBrain injuryNLP toolsF1 scoreNER modelTransformer architectureClinical textEncoder RepresentationsNLP algorithmNLP modelsCT reportsCustom dictionaryTraining setCross-validation performancePerformance metricsAvailable new toolsFocused Management of Patients With Severe Acute Brain Injury and ARDS
Kim JA, Wahlster S, LaBuzetta JN, Nobleza COS, Johnson NJ, Rubinos C, Malaiyandi D, O'Phelan KH, Mainali S, Sarwal A, Gilmore EJ. Focused Management of Patients With Severe Acute Brain Injury and ARDS. CHEST Journal 2021, 161: 140-151. PMID: 34506794, PMCID: PMC8423666, DOI: 10.1016/j.chest.2021.08.066.Peer-Reviewed Original ResearchConceptsSevere acute brain injuryAcute brain injuryBrain injuryTreatment strategiesHigh-acuity patient populationMainstay of treatmentHypothetical case scenariosSevere ARDSConcurrent diseasesPatient populationTreatment decisionsARDSConcomitant managementLung physiologyTreatment conceptNarrative reviewConcomitant occurrenceSimultaneous managementPatientsCOVID-19 pandemicInjuryNoninvasive monitoringFocused managementPhysiological basisManagement
2021
A model of metabolic supply-demand mismatch leading to secondary brain injury
Song JL, Kim JA, Struck AF, Zhang R, Westover MB. A model of metabolic supply-demand mismatch leading to secondary brain injury. Journal Of Neurophysiology 2021, 126: 653-667. PMID: 34232754, PMCID: PMC8815783, DOI: 10.1152/jn.00674.2020.Peer-Reviewed Original ResearchConceptsPrimary brain injurySecondary brain injuryAcute brain injuryBrain injuryExtracellular potassiumAdditional brain injuryAssociation of seizuresIschemic strokeNeurologic insultPreventable complicationsSeizure activityCommon sequalaeTissue hypoxiaMetabolic crisisSeizuresInjuryExcitotoxicityPatientsCommon associationAssociationCurrent practiceExcitotoxityComplicationsHemorrhageIschemia
2020
Detecting Seizures and Epileptiform Abnormalities in Acute Brain Injury
Singla S, Garcia GE, Rovenolt GE, Soto AL, Gilmore EJ, Hirsch LJ, Blumenfeld H, Sheth KN, Omay SB, Struck AF, Westover MB, Kim JA. Detecting Seizures and Epileptiform Abnormalities in Acute Brain Injury. Current Neurology And Neuroscience Reports 2020, 20: 42. PMID: 32715371, PMCID: PMC9353690, DOI: 10.1007/s11910-020-01060-4.Peer-Reviewed Original ResearchConceptsIctal-interictal continuumBrain injuryAcute brain injuryBetter clinical outcomesTraumatic brain injuryRecent FindingsCurrent literatureIncreased morbidityClinical outcomesEpileptiform abnormalitiesEEG findingsMortality riskEEG monitoringEpileptiform patternsPrognostic modelSeizuresClinical settingInjuryLogistical barriersElectroencephalogram studyUse of EEGABIPractical barriersEEG analysisEEGMorbidity