2024
Dapagliflozin enhances arterial and venous compliance during exercise in heart failure with preserved ejection fraction
Tada A, Burkhoff D, Naser J, Harada T, Pourmussa B, Reddy Y, Jensen M, Carter R, Testani J, Chirinos J, Borlaug B. Dapagliflozin enhances arterial and venous compliance during exercise in heart failure with preserved ejection fraction. European Heart Journal 2024, 45: ehae666.782. DOI: 10.1093/eurheartj/ehae666.782.Peer-Reviewed Original ResearchPulmonary capillary wedge pressureSodium-glucose cotransporter-2 inhibitorsSystemic arterial complianceEffects of dapagliflozinVenous capacitancePeak exerciseArterial complianceHemodynamic congestionHeart failureTotal arterial complianceImproved systemic arterial complianceInvasive hemodynamic exercise testingTime of baseline evaluationSystolic BPBlood volumeHemodynamic exercise testingCapillary wedge pressureCotransporter-2 inhibitorsSystemic vascular resistanceImproving clinical outcomesTotal blood volumeRadial artery pressureFluid-filled catheterWedge pressureStressed blood volume
2010
Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival
Testani JM, Chen J, McCauley BD, Kimmel SE, Shannon RP. Potential Effects of Aggressive Decongestion During the Treatment of Decompensated Heart Failure on Renal Function and Survival. Circulation 2010, 122: 265-272. PMID: 20606118, PMCID: PMC3025294, DOI: 10.1161/circulationaha.109.933275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood ProteinsBlood VolumeExtracellular FluidFemaleGlomerular Filtration RateHeart FailureHematocritHumansKidneyMaleMiddle AgedPulmonary Wedge PressureSerum AlbuminSodium Chloride Symporter InhibitorsSodium Potassium Chloride Symporter InhibitorsTreatment OutcomeVentricular PressureConceptsDecompensated heart failureRenal functionAggressive decongestionHeart failurePulmonary Artery Catheterization Effectiveness trialPulmonary capillary wedge pressureAggressive fluid removalCapillary wedge pressureIntravascular volume depletionRight atrial pressureCongestive heart failureEvidence of hemoconcentrationAggressive diuresisIntravascular substancesWedge pressureAtrial pressureBaseline characteristicsLoop diureticsTop tertileVolume depletionEffectiveness trialExtravascular fluidFluid removalHemoconcentrationHigh doses