Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival
Li H, Ma X, Wang J, Koontz J, Nucci M, Sklar J. Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 20001-20006. PMID: 18077430, PMCID: PMC2148412, DOI: 10.1073/pnas.0709986104.Peer-Reviewed Original ResearchMeSH KeywordsAllelesApoptosisCarrier ProteinsCell LineCell Line, TumorCell ProliferationCell SurvivalCo-Repressor ProteinsDNA-Binding ProteinsFemaleGene FusionGene RearrangementHumansNeoplasm ProteinsNuclear ProteinsPolycomb Repressive Complex 2Sarcoma, Endometrial StromalTranscription FactorsTranslocation, GeneticConceptsAllelic exclusionHistone 3 lysine 27 trimethylationPolycomb group genesChromosomal translocationsLikely functional importanceLysine 27 trimethylationPolycomb protein EZH2Protein EZH2Group genesUnrearranged copyGenetic pathwaysMalignant formNormal proliferation rateJAZF1 geneFunctional importanceGene fusionsCell survivalHEK293 cellsGenesCultured cellsCell growthEndometrial stromal tumorsCellular proliferationCell proliferationSUZ12