Featured Publications
Examining sex as a predictor and moderator of treatment outcomes for binge‐eating disorder: Analysis of aggregated randomized controlled trials
Lydecker JA, Gueorguieva R, Masheb R, White MA, Grilo CM. Examining sex as a predictor and moderator of treatment outcomes for binge‐eating disorder: Analysis of aggregated randomized controlled trials. International Journal Of Eating Disorders 2019, 53: 20-30. PMID: 31497876, PMCID: PMC6983351, DOI: 10.1002/eat.23167.Peer-Reviewed Original ResearchConceptsBinge-eating disorderEating-disorder psychopathologyCognitive behavioral therapySelf-report measuresModerators of outcomeTreatment outcomesBehavioral weight lossStatistical Manual-Fourth EditionSignificant moderatorWeight lossControl conditionModeratorCourse of treatmentBetter treatment outcomesGreater weight lossMain effectStructured interviewsTreatment settingsPsychopathologyMultimodal treatmentPatient groupRCT studiesMedical CenterBed treatmentParticipantsWeighty decisions: How symptom severity and weight impact perceptions of bulimia nervosa
Galbraith K, Elmquist J, White MA, Grilo CM, Lydecker JA. Weighty decisions: How symptom severity and weight impact perceptions of bulimia nervosa. International Journal Of Eating Disorders 2019, 52: 1035-1041. PMID: 31240769, PMCID: PMC6779161, DOI: 10.1002/eat.23125.Peer-Reviewed Original ResearchConceptsBulimia nervosaSymptom frequencySerious mental health concernsMental health concernsPatient weightWeight statusMental illnessSymptom severityOverweightYoung womenHealth concernWeight stigmaSignificant differencesPatientsNervosaCurrent studyParticipantsVariables of interestIllnessNegative attitudesSeverityWomenExamining Race as a Predictor and Moderator of Treatment Outcomes for Binge-Eating Disorder: Analysis of Aggregated Randomized Controlled Trials
Lydecker JA, Gueorguieva R, Masheb R, White MA, Grilo CM. Examining Race as a Predictor and Moderator of Treatment Outcomes for Binge-Eating Disorder: Analysis of Aggregated Randomized Controlled Trials. Journal Of Consulting And Clinical Psychology 2019, 87: 530-540. PMID: 31008634, PMCID: PMC6589831, DOI: 10.1037/ccp0000404.Peer-Reviewed Original ResearchConceptsBinge-eating disorderWhite participantsCognitive behavioral therapySelf-report measuresTreatment outcomesBinge-eating remissionModerate treatment outcomeBinge Eating DisorderBinge-eating episodesMain effectBlack participantsWeight lossBehavioral weight lossEvidence-based treatmentsLower depressionTreatment researchRandomized Controlled TrialsBetter treatment outcomesControl conditionParticipantsControlled TrialsMultimodal treatmentPercent weight lossPatient groupModeratorI didn't want them to see: Secretive eating among adults with binge‐eating disorder
Lydecker JA, Grilo CM. I didn't want them to see: Secretive eating among adults with binge‐eating disorder. International Journal Of Eating Disorders 2019, 52: 153-158. PMID: 30623972, PMCID: PMC6368878, DOI: 10.1002/eat.23002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBinge-Eating DisorderBody ImageBody WeightFemaleHumansMaleMiddle AgedYoung AdultConceptsBody mass indexBinge-eating disorderEating-disorder psychopathologyObjective binge-eating episodesSecretive eatingBinge-eating episodesGreater eating-disorder psychopathologyGreater body mass indexHigher depression scoresClinical characteristicsMass indexTreatment-seeking adultsDepression scoresPatientsShape/weightWeight concernsAdultsEatingSelf-report measuresDisordersShape concernsEpisodesGreater proportionPsychopathologyTreatment formulationForm and Formulation: Examining the Distinctiveness of Body Image Constructs in Treatment-Seeking Patients With Binge-Eating Disorder
Lydecker JA, White MA, Grilo CM. Form and Formulation: Examining the Distinctiveness of Body Image Constructs in Treatment-Seeking Patients With Binge-Eating Disorder. Journal Of Consulting And Clinical Psychology 2017, 85: 1095-1103. PMID: 29083224, PMCID: PMC5679782, DOI: 10.1037/ccp0000258.Peer-Reviewed Original ResearchConceptsBody image variablesBody image disturbanceBody image constructsBinge-eating disorderImage constructImage variablesWeight/shape overvaluationBinge-eating frequencyInvestigator-based interviewBiopsychosocial featuresEating-disorder psychopathologyTreatment-seeking patientsShape preoccupationShape dissatisfactionShape overvaluationShape concernsCore aspectsCurrent studyTreatment formulationConstructsImportant distinctionDifferent aspectsOvervaluationPreoccupationDisordersCognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial
Grilo C, Lydecker J, Gueorguieva R. Cognitive‐behavioral therapy for binge‐eating disorder for non‐responders to initial acute treatments: Randomized controlled trial. International Journal Of Eating Disorders 2023, 56: 1544-1553. PMID: 37144325, PMCID: PMC10524840, DOI: 10.1002/eat.23975.Peer-Reviewed Original ResearchConceptsInitial acute treatmentBinge-eating disorderCognitive behavioral therapyAcute treatmentBinge-eating frequencyInitial interventionTherapist-led cognitive behavioural therapyInitial pharmacological treatmentTreat remission ratesEvidence-based treatmentsSingle-site trialAcute efficacyRemission rateAdult patientsInitial treatmentPharmacological treatmentPatientsPosttreatment assessmentBehavioral treatmentSufficient benefitTherapyDisordersInterventionTreatmentPharmacotherapy
2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionNaltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlacebo
2022
Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial
Grilo CM, Lydecker JA, Fineberg SK, Moreno JO, Ivezaj V, Gueorguieva R. Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial. American Journal Of Psychiatry 2022, 179: 927-937. PMID: 36285406, PMCID: PMC9722598, DOI: 10.1176/appi.ajp.20220267.Peer-Reviewed Original ResearchConceptsBehavioral weight loss therapyBinge-eating disorderPlacebo groupBupropion groupWeight lossRandomized double-blind placebo-controlled trialDouble-blind placebo-controlled trialLogistic regressionBinge-eating remissionPlacebo-controlled trialWeight loss therapyDouble-blind placeboSerious public health problemPublic health problemEvidence-based treatmentsRate of participantsBinge-eating frequencyBinge Eating DisorderMedical comorbiditiesRemission rateLoss therapyPercent weight lossMixed modelsFunctional impairmentSecondary measures
2020
Naltrexone + Bupropion Combination for the Treatment of Binge-eating Disorder with Obesity: A Randomized, Controlled Pilot Study
Grilo CM, Lydecker JA, Morgan PT, Gueorguieva R. Naltrexone + Bupropion Combination for the Treatment of Binge-eating Disorder with Obesity: A Randomized, Controlled Pilot Study. Clinical Therapeutics 2020, 43: 112-122.e1. PMID: 33218742, PMCID: PMC7902424, DOI: 10.1016/j.clinthera.2020.10.010.Peer-Reviewed Original ResearchConceptsBinge-eating disorderEating-disorder psychopathologyPilot RCTTreatment of BEDOutcome time pointDouble-blind treatmentPercentage of patientsControlled Pilot StudyDiscontinuation of medicationTreatment of bingeEvidence-based treatmentsBinge-eating frequencyBupropion combinationAdult patientsAdverse eventsComorbid obesitySecondary outcomesPrimary outcomeAcute effectsFunctional impairmentPlaceboLong-term effectsPatientsMost outcomesObesityDoes Bariatric Binge‐Eating Size Matter? Conceptual Model and Empirical Support
Ivezaj V, Lydecker JA, Wiedemann AA, Duffy AJ, Grilo CM. Does Bariatric Binge‐Eating Size Matter? Conceptual Model and Empirical Support. Obesity 2020, 28: 1645-1651. PMID: 32729221, PMCID: PMC7484317, DOI: 10.1002/oby.22876.Peer-Reviewed Original ResearchConceptsEating Disorder Examination-Bariatric Surgery Version interviewBariatric surgeryEpisode groupBinge sizeFunctional impairmentDepressive symptomsNew classification systemMental health-related qualityLoss of controlPostsurgical bariatric patientsSurgery 6 monthsHealth-related qualityCross-sectional studyBinge-eating episodesQuality of lifeObjective binge-eating episodesBariatric patientsClinical outcomesEating Disorder PsychopathologyBinge-eating groupBinge eatingSurgeryClassification systemDistinct psychopathologySymptomsLanguage Matters: Patients’ Preferred Terms for Discussing Obesity and Disordered Eating with Health Care Providers After Bariatric Surgery
Ivezaj V, Lydecker JA, Grilo CM. Language Matters: Patients’ Preferred Terms for Discussing Obesity and Disordered Eating with Health Care Providers After Bariatric Surgery. Obesity 2020, 28: 1412-1418. PMID: 32662251, PMCID: PMC7501175, DOI: 10.1002/oby.22868.Peer-Reviewed Original ResearchConceptsHealth care providersBariatric surgeryCare providersCross-sectional studyPatient-centered carePreferred termHealth care systemTreatment trialsPatient preferencesSurgeryBehavioral treatmentControl eatingLanguage preferenceCare systemRacial differencesObesityPatientsWeight biasProvidersBMIWeightIndividualsControlTrialsCareTesting the Validity and Clinical Utility of the Severity Specifiers for Binge-Eating Disorder for Predicting Treatment Outcomes
Lydecker JA, Ivezaj V, Grilo CM. Testing the Validity and Clinical Utility of the Severity Specifiers for Binge-Eating Disorder for Predicting Treatment Outcomes. Journal Of Consulting And Clinical Psychology 2020, 88: 172-178. PMID: 31894997, PMCID: PMC7286612, DOI: 10.1037/ccp0000464.Peer-Reviewed Original ResearchConceptsBinge-eating disorderCognitive behavioral therapyBehavioral weight lossSeverity specifiersSelf-report measuresTreatment-seeking individualsBinge-eating frequencyBinge Eating DisorderEating-disorder psychopathologyClinical utilityTreatment outcomesSeverity categoriesPredicting Treatment OutcomeWeight lossFuture researchMain effectDepression scoresStatistical ManualParticipantsTesting treatmentsMultimodal treatmentPharmacological treatmentTreatment responseMedical CenterLarge series
2019
Associations of Weight Bias with Disordered Eating Among Latino and White Men
Lydecker JA, Cotter E, Grilo CM. Associations of Weight Bias with Disordered Eating Among Latino and White Men. Obesity 2019, 27: 1982-1987. PMID: 31603628, PMCID: PMC6868326, DOI: 10.1002/oby.22632.Peer-Reviewed Original ResearchConceptsWhite menWeight/shapeWeight biasLatino menWeight-biased attitudesNegative attitudesControllability of obesityEating-disordered behaviorObesityDecreased useDietary restraintMenBody dissatisfactionOnline batteryCompensatory behaviorsAssociationPsychopathologyWeaker beliefsFuture researchBeliefsAttitudesSecretive eating and binge eating following bariatric surgery
Lydecker JA, Ivezaj V, Grilo CM. Secretive eating and binge eating following bariatric surgery. International Journal Of Eating Disorders 2019, 52: 935-940. PMID: 31033037, PMCID: PMC6687553, DOI: 10.1002/eat.23089.Peer-Reviewed Original ResearchConceptsBariatric surgerySecretive eatingClinical variablesDisorder psychopathologyPost-bariatric surgery patientsBed statusBinge-eating disorderBinge-eating episodesInvestigator-based interviewSurgery patientsTreatment-seeking adultsPatientsBariatric bedsControl eatingSurgeryDepression measuresWeight concernsStrong associationRelevant markersPsychopathology severityEatingShape concernsSize criteriaPsychopathologyAdultsRacial Comparisons of Postoperative Weight Loss and Eating‐Disorder Psychopathology Among Patients Following Sleeve Gastrectomy Surgery
Ivezaj V, Fu E, Lydecker JA, Duffy AJ, Grilo CM. Racial Comparisons of Postoperative Weight Loss and Eating‐Disorder Psychopathology Among Patients Following Sleeve Gastrectomy Surgery. Obesity 2019, 27: 740-745. PMID: 30925196, PMCID: PMC6478551, DOI: 10.1002/oby.22446.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryEating-disorder psychopathologyWhite patientsBlack patientsGastrectomy surgeryWeight lossEating Disorder Examination-Bariatric Surgery VersionMedical Outcomes Study Short-Form Health SurveyPercent excess weight lossPercent total weight lossMental health-related qualityShort Form Health SurveyPsychosocial functioningExcess weight lossPostoperative weight lossHealth-related qualityBeck Depression Inventory-IIRacial differencesBinge-eating disorderPresurgical BMISleeve gastrectomyLess weight lossEating Disorder PsychopathologyHealth SurveyMeal patterns
2018
Comparing men and women with binge‐eating disorder and co‐morbid obesity
Lydecker JA, Grilo CM. Comparing men and women with binge‐eating disorder and co‐morbid obesity. International Journal Of Eating Disorders 2018, 51: 411-417. PMID: 29493793, PMCID: PMC5980708, DOI: 10.1002/eat.22847.Peer-Reviewed Original ResearchMeSH KeywordsBinge-Eating DisorderDepressionFemaleHumansMaleMiddle AgedObesity, MorbidSelf ReportSex CharacteristicsConceptsBody mass indexBinge-eating disorderEating-disorder psychopathologyBinge-eating episodesBinge-eating behaviorClinical presentationResearch cliniciansHigher body mass indexCo-morbid obesityDSM-IV disordersStructured Clinical InterviewEating Disorder Examination interviewAge of onsetBinge-eating frequencyRace/ethnicityMass indexBED diagnosisClinical InterviewYounger ageObesityExamination interviewWomenMenAgeDisorders
2017
Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention
Marek RJ, Coulon SM, Brown JD, Lydecker JA, Marek S, Malcolm R, O'Neil PM. Characteristics of Weight Loss Trajectories in a Comprehensive Lifestyle Intervention. Obesity 2017, 25: 2062-2067. PMID: 29086487, DOI: 10.1002/oby.21942.Peer-Reviewed Original ResearchConceptsWeight loss trajectoriesAverage weight lossWeight lossLifestyle interventionWeight changeWeight gainComprehensive lifestyle interventionLatent class analysisMeal replacement dietMore tailored interventionsLifestyle change counselingWeekly weight changesWeekly weight gainPercent weight lossLess optimal outcomesLifestyle programEfficacy dataGroup 2Group 1Group 3Class analysisPatientsTailored interventionsOptimal outcomesPercent weight gainRumination in Patients with Binge‐Eating Disorder and Obesity: Associations with Eating‐Disorder Psychopathology and Weight‐bias Internalization
Wang SB, Lydecker JA, Grilo CM. Rumination in Patients with Binge‐Eating Disorder and Obesity: Associations with Eating‐Disorder Psychopathology and Weight‐bias Internalization. European Eating Disorders Review 2017, 25: 98-103. PMID: 28078784, PMCID: PMC5318238, DOI: 10.1002/erv.2499.Peer-Reviewed Original ResearchConceptsShape/weightWeight bias internalizationEating-disorder psychopathologyBinge-eating disorderCognitive processesGreater eating-disorder psychopathologyImportant cognitive processesOvervaluation of shapeGreater weight bias internalizationHierarchical multiple regressionTreatment-seeking patientsGreater ruminationRuminationDiscrimination experiencesPhysical healthPsychopathologyNegative attitudesMultiple regressionOvervaluationObesity treatmentComorbid obesityAttitudesDisordersExperienceFindings
2016
Loss-of-control eating following sleeve gastrectomy surgery
Ivezaj V, Kessler EE, Lydecker JA, Barnes RD, White MA, Grilo CM. Loss-of-control eating following sleeve gastrectomy surgery. Surgery For Obesity And Related Diseases 2016, 13: 392-398. PMID: 27913121, PMCID: PMC5357454, DOI: 10.1016/j.soard.2016.09.028.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryGastrectomy surgeryWeight lossEating Disorder Examination-Bariatric Surgery VersionPoorer weight loss outcomesBED criteriaLower percent weight lossPoor weight lossWeight loss outcomesBody mass indexEating-disorder psychopathologyBinge-eating disorderRegular compensatory behaviorsCurrent mean ageUnited States METHODSBariatric surgeryPostoperative lossMass indexPercent weight lossMean ageMonths postsurgeryPoor outcomeLoss outcomesGreater severitySurgery