2022
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Eyre MT, Souza FN, Carvalho-Pereira T, Nery N, de Oliveira D, Cruz JS, Sacramento GA, Khalil H, Wunder EA, Hacker KP, Hagan JE, Childs JE, Reis MG, Begon M, Diggle PJ, Ko AI, Giorgi E, Costa F. Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil. ELife 2022, 11: e73120. PMID: 36111781, PMCID: PMC9560157, DOI: 10.7554/elife.73120.Peer-Reviewed Original ResearchConceptsInfection riskSignificant global public health burdenCommunity-based cohort studyGlobal public health burdenPublic health burdenAgents of leptospirosisExposure of interestYears of agePublic health interventionsHigh-risk communitiesJoint spatial modellingZoonotic spilloverCohort studyHuman infection riskMale genderSerological evidenceHealth burdenLeptospira infectionLeptospiral infectionInfection rateHealth interventionsEco-epidemiological studiesHealth surveillanceFundação de Amparo à PesquisaOswaldo Cruz Foundation
2020
Amplification of pathogenic Leptospira infection with greater abundance and co‐occurrence of rodent hosts across a counter‐urbanizing landscape
Peterson AC, Ghersi BM, Riegel C, Wunder EA, Childs JE, Blum MJ. Amplification of pathogenic Leptospira infection with greater abundance and co‐occurrence of rodent hosts across a counter‐urbanizing landscape. Molecular Ecology 2020, 30: 2145-2161. PMID: 33107122, DOI: 10.1111/mec.15710.Peer-Reviewed Original Research
2007
Pre-spillover Prevention of Emerging Zoonotic Diseases: What Are the Targets and What Are the Tools?
Childs J. Pre-spillover Prevention of Emerging Zoonotic Diseases: What Are the Targets and What Are the Tools? Current Topics In Microbiology And Immunology 2007, 315: 389-443. PMID: 17848073, PMCID: PMC7120954, DOI: 10.1007/978-3-540-70962-6_16.Peer-Reviewed Original ResearchIntroduction: Conceptualizing and Partitioning the Emergence Process of Zoonotic Viruses from Wildlife to Humans
Childs J, Richt J, Mackenzie J. Introduction: Conceptualizing and Partitioning the Emergence Process of Zoonotic Viruses from Wildlife to Humans. Current Topics In Microbiology And Immunology 2007, 315: 1-31. PMID: 17848058, PMCID: PMC7122288, DOI: 10.1007/978-3-540-70962-6_1.Peer-Reviewed Original Research
2006
Animal-based national surveillance for zoonotic disease: Quality, limitations, and implications of a model system for monitoring rabies
Childs J, Krebs J, Real L, Gordon E. Animal-based national surveillance for zoonotic disease: Quality, limitations, and implications of a model system for monitoring rabies. Preventive Veterinary Medicine 2006, 78: 246-261. PMID: 17129622, PMCID: PMC7114326, DOI: 10.1016/j.prevetmed.2006.10.014.Peer-Reviewed Original Research
2005
Persistence of elevated rabies prevention costs following post-epizootic declines in rates of rabies among raccoons (Procyon lotor)
Gordon E, Krebs J, Rupprecht C, Real L, Childs J. Persistence of elevated rabies prevention costs following post-epizootic declines in rates of rabies among raccoons (Procyon lotor). Preventive Veterinary Medicine 2005, 68: 195-222. PMID: 15820116, DOI: 10.1016/j.prevetmed.2004.12.007.Peer-Reviewed Original ResearchSpatial Dynamics and Molecular Ecology of North American Rabies
Real L, Russell C, Waller L, Smith D, Childs J. Spatial Dynamics and Molecular Ecology of North American Rabies. Journal Of Heredity 2005, 96: 253-260. PMID: 15677743, DOI: 10.1093/jhered/esi031.Peer-Reviewed Original ResearchConceptsMacro-evolutionary time scalesLocal environmental variablesRemarkable model systemEvolutionary geneticsMolecular ecologyHost specificityPopulation ecologySpatial dynamicsAccidental introductionWildlife populationsNorth AmericaRNA virusesPattern of emergenceEnvironmental variablesGenetic heterogeneityEastern United StatesRaccoon populationsModel systemEcologyImportant viral zoonotic diseaseVirginia borderEpidemic expansionRegions of EuropeVirus variantsTemporal occurrence
2004
Temporal dynamics of rabies in a wildlife host and the risk of cross-species transmission
GORDON E, CURNS A, KREBS J, RUPPRECHT C, REAL L, CHILDS J. Temporal dynamics of rabies in a wildlife host and the risk of cross-species transmission. Epidemiology And Infection 2004, 132: 515-524. PMID: 15188720, PMCID: PMC2870130, DOI: 10.1017/s0950268804002067.Peer-Reviewed Original ResearchZoonotic viruses of wildlife: hither from yon
Childs J. Zoonotic viruses of wildlife: hither from yon. Archives Of Virology. Supplementa 2004, 1-11. PMID: 15119758, DOI: 10.1007/978-3-7091-0572-6_1.Peer-Reviewed Original ResearchConceptsZoonotic virusesCross-species virus transmissionImportant zoonotic virusesCross-species transmissionSubsequent disease outbreaksWest Nile virusEvolutionary factorsVirus adaptationWildlife diseasesSpillover hostsVirus emergenceWildlife reservoir hostsRecent discoveryReservoir hostsNipah virusHostNile virusInter-species contactVirusDisease outbreaksVirus transmissionSpeciesWildlifeHendraEpidemic emergence
2001
Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato.
Castro M, Nicholson W, Kramer V, Childs J. Persistent infection in Neotoma fuscipes (Muridae: Sigmodontinae) with Ehrlichia phagocytophila sensu lato. American Journal Of Tropical Medicine And Hygiene 2001, 65: 261-7. PMID: 11693866, DOI: 10.4269/ajtmh.2001.65.261.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialArachnid VectorsBase SequenceBorrelia burgdorferiCaliforniaDisease ReservoirsDNA, BacterialEhrlichiaEhrlichiosisFemaleFluorescent Antibody Technique, IndirectHeat-Shock ProteinsHumansIxodesMaleMicePolymerase Chain ReactionRatsRodent DiseasesSeasonsSeroepidemiologic StudiesSigmodontinaeZoonosesConceptsPolymerase chain reaction testingGroESL heat shock operonPersistent infectionReaction testingRatsE. phagocytophilaLyme diseaseBorrelia burgdorferiMiceSeropositive animalsDusky-footed wood ratsPCRWood ratsSeroreversionSensu latoSeroconversionSeropositiveBiopsySerologySeroreactivityInfectionDiseaseBloodAdult Ixodes pacificus CooleySerumUrban Zoonoses Caused by Bartonella, Coxiella, Ehrlichia, and Rickettsia Species
Comer J, Paddock C, Childs J. Urban Zoonoses Caused by Bartonella, Coxiella, Ehrlichia, and Rickettsia Species. Vector-Borne And Zoonotic Diseases 2001, 1: 91-118. PMID: 12653141, DOI: 10.1089/153036601316977714.Peer-Reviewed Original Research
1999
Search for the Ebola Virus Reservoir in Kikwit, Democratic Republic of the Congo: Reflections on a Vertebrate Collection
Leirs H, Mills J, Krebs J, Childs J, Akaibe D, Woollen N, Ludwig G, Peters C, Ksiazek T. Search for the Ebola Virus Reservoir in Kikwit, Democratic Republic of the Congo: Reflections on a Vertebrate Collection. The Journal Of Infectious Diseases 1999, 179: s155-s163. PMID: 9988179, DOI: 10.1086/514299.Peer-Reviewed Original ResearchConceptsRare speciesVirus ecologyVertebrate collectionsPrimary casesTarget speciesEbola virusPresence of antibodiesEbola hemorrhagic feverSpeciesVirus reservoirLack of informationHemorrhagic feverEcologic investigationsVertebratesHuman outbreaksHabitatsVirusEcologyKikwitFurther studiesDaily activitiesSelect groupSample size limitationsEpidemiologyLong-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: Rationale, Potential, and Methods - Volume 5, Number 1—February 1999 - Emerging Infectious Diseases journal - CDC
Mills J, Yates T, Ksiazek T, Peters C, Childs J. Long-Term Studies of Hantavirus Reservoir Populations in the Southwestern United States: Rationale, Potential, and Methods - Volume 5, Number 1—February 1999 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 1999, 5: 95-101. PMID: 10081676, PMCID: PMC2627686, DOI: 10.3201/eid0501.990111.Peer-Reviewed Original ResearchConceptsHantavirus pulmonary syndromeInfectious Diseases journal - CDCIncidence of infectionHuman hantavirus diseasePulmonary syndromeHantavirus diseaseHantavirus infectionHemorrhagic feverRenal syndromeDisease controlLong-term studiesHantavirus reservoir populationsZoonotic agentsPrevention measuresSyndromeTerm studiesUnited StatesInfectionDiseaseHPS outbreaksPreventionHuman riskRodent hostsHuman diseasesReservoir populations
1998
Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida.
Glass G, Livingstone W, Mills J, Hlady W, Fine J, Biggler W, Coke T, Frazier D, Atherley S, Rollin P, Ksiazek T, Peters C, Childs J. Black Creek Canal Virus infection in Sigmodon hispidus in southern Florida. American Journal Of Tropical Medicine And Hygiene 1998, 59: 699-703. PMID: 9840584, DOI: 10.4269/ajtmh.1998.59.699.Peer-Reviewed Original ResearchEpidemiology of human rabies in the United States, 1980 to 1996.
Noah D, Drenzek C, Smith J, Krebs J, Orciari L, Shaddock J, Sanderlin D, Whitfield S, Fekadu M, Olson J, Rupprecht C, Childs J. Epidemiology of human rabies in the United States, 1980 to 1996. Annals Of Internal Medicine 1998, 128: 922-30. PMID: 9634432, DOI: 10.7326/0003-4819-128-11-199806010-00012.Peer-Reviewed Original ResearchConceptsPostexposure prophylaxisHuman rabiesAnimal bitesBat bitesRabies virus variantVirus variantsLaboratory-confirmed casesMedical personnelExposure historyDiagnostic laboratory testsLocal health authoritiesDiagnosis of rabiesRabies virus transmissionInfectious salivaInsignificant woundMost patientsClinical courseClinical featuresClinical presentationDefinite historyAntemortem diagnosisCase reportClinical differencesClinical signsDifferential diagnosis
1997
Survey of veterinary professionals and other veterinary conference attendees for antibodies to Bartonella henselae and B quintana.
Noah D, Kramer C, Verbsky M, Rooney J, Smith K, Childs J. Survey of veterinary professionals and other veterinary conference attendees for antibodies to Bartonella henselae and B quintana. Journal Of The American Veterinary Medical Association 1997, 210: 342-4. PMID: 9057914, DOI: 10.2460/javma.1997.210.03.342.Peer-Reviewed Original ResearchConceptsCat-scratch diseaseB quintanaBartonella henselaeOccupational groupsVeterinary techniciansIllness consistentPrevious diagnosisEpidemiologic characteristicsPotential confoundersOverall seroprevalenceUnknown prevalenceB henselaeEpidemiologic SurveyHospital staffCat ownershipSp infectionExposure informationSerum samplesVeterinary conferencesHenselaeSeropositivitySpecies of BartonellaSeroprevalenceInfectionUnknown duration
1995
Rabies surveillance in the United States during 1994.
Krebs J, Strine T, Smith J, Rupprecht C, Childs J. Rabies surveillance in the United States during 1994. Journal Of The American Veterinary Medical Association 1995, 207: 1562-75. PMID: 7493894, DOI: 10.2460/javma.1995.207.12.1562.Peer-Reviewed Original ResearchEAR BIOPSY LOCATION INFLUENCES DETECTION OF BORRELIA BURGDORFERI BY PCR, BUT NOT BY CULTURE IN NATURALLY INFECTED PEROMYSCUS LEUCOPUS
Hofmeister E, Childs J. EAR BIOPSY LOCATION INFLUENCES DETECTION OF BORRELIA BURGDORFERI BY PCR, BUT NOT BY CULTURE IN NATURALLY INFECTED PEROMYSCUS LEUCOPUS. Journal Of Wildlife Diseases 1995, 31: 345-351. PMID: 8592355, DOI: 10.7589/0090-3558-31.3.345.Peer-Reviewed Original ResearchConceptsEar biopsy samplesPolymerase chain reactionBiopsy samplesBiopsy locationB. burgdorferiBorrelia burgdorferiInfected micePeripheral samplesIndividual miceInfection statusMore tissue samplesMiceTissue samplesHigh concordanceChain reactionOrgan cultureBurgdorferiGreater frequencyEar samplesWhite-footed miceEnzootic areaEarCentral sample