2022
Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain
Luo X, Fang W, Lin X, Guo X, Chen Y, Tan Y, Wang L, Jing X, Wang X, Zhang Y, Yu T, Ide J, Cao Y, Yang L, Li CR. Sex-different interrelationships of rs945270, cerebral gray matter volumes, and attention deficit hyperactivity disorder: a region-wide study across brain. Translational Psychiatry 2022, 12: 225. PMID: 35654767, PMCID: PMC9163172, DOI: 10.1038/s41398-022-02007-8.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD symptom scoresGray matter volumeDeficit hyperactivity disorderCortical gray matter volumePutamen gray matter volumesHyperactivity disorderADHD riskMatter volumePathogenesis of ADHDMediation effectBrain regionsLeft putamenCerebral gray matter volumeCerebral regionsRelevant covariatesGray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability
Chen Y, Ide JS, Li CS, Chaudhary S, Le TM, Wang W, Zhornitsky S, Zhang S, Li C. Gray matter volumetric correlates of dimensional impulsivity traits in children: Sex differences and heritability. Human Brain Mapping 2022, 43: 2634-2652. PMID: 35212098, PMCID: PMC9057091, DOI: 10.1002/hbm.25810.Peer-Reviewed Original ResearchConceptsGray matter volumeImpulsivity traitsPositive urgencyVolumetric correlatesSensation seekingHigher positive urgencyMid-cingulate cortexSex differencesVoxel-based morphometry analysisSmaller gray matter volumeImpulsivity dimensionsSubsample of twinsDistinct correlatesCingulate cortexPrecentral gyrusSubcortical gray matter volumesMatter volumeTotal intracranial volumeSeekingImpulsivityMorphometry analysisPrevious researchInsulaCorrelatesGirls
2021
Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β‑Hairpin Antimicrobial Peptides
Buri M, Sperandio L, de Souza K, Antunes F, Rezende M, Melo C, Pinhal M, Barros C, Fernig D, Yates E, Ide J, Smaili S, Riske K, Nader H, dos Santos Tersariol I, Lima M, Judice W, Miranda A, Paredes-Gamero E. Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β‑Hairpin Antimicrobial Peptides. ACS Applied Bio Materials 2021, 4: 6488-6501. PMID: 35006908, DOI: 10.1021/acsabm.1c00390.Peer-Reviewed Original ResearchConceptsCell deathAntimicrobial peptidesSecondary structure homologyControl cell deathΒ-hairpin antimicrobial peptidesCommon mechanismCytotoxicity of AMPsStructure homologyMembrane permeabilizationGene expressionMitochondrial potentialCytotoxic modeEndocytosisCell membraneCell tumor modelΒ-hairpin peptidesAMP stimulationPeptidesDynaminHomologyPermeabilizationGlycosaminoglycansMechanismProteinCytotoxicity
2018
Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers
Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li C. Problem Drinking, Alcohol Expectancy, and Thalamic Resting-State Functional Connectivity in Nondependent Adult Drinkers. Brain Connectivity 2018, 8: 487-502. PMID: 30198312, PMCID: PMC6207153, DOI: 10.1089/brain.2018.0633.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestResting-state functional connectivityThalamic connectivityCaudate connectivityFrontal associationThalamic dysfunctionCaudate headProblem drinkingWhole-brain linear regressionAE scoreSubcortical structuresFunctional connectivityBilateral caudate headRight caudate headDisorders Identification TestSex differencesThalamic subdivisionsThalamic subregionsParietal associationAlcohol misuseThalamusWhite matter tractographyAUDIT scoresNondependent drinkersAlcohol expectanciesOxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males
Ide J, Nedic S, Wong K, Strey S, Lawson E, Dickerson B, Wald L, La Camera G, Mujica-Parodi L. Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males. NeuroImage 2018, 174: 35-43. PMID: 29486321, DOI: 10.1016/j.neuroimage.2018.02.035.Peer-Reviewed Original ResearchConceptsUltra-high field fMRIPre-existing beliefsReinforcement learningBrain encodingGeneral reinforcement learningNeuroeconomic taskIntranasal oxytocinFace of informationField fMRIFeedback learningFMRI activationExperimental paradigmNegative rewardsOrbitofrontal cortexSocial learningReward circuitBehavioral trajectoriesFunctional connectivityConnectivity analysisSocial contextSubjects' behaviorSocial relationshipsBehavioral effectsLearningBayesian expectation
2016
Abnormal reward circuitry in anorexia nervosa: A longitudinal, multimodal MRI study
Cha J, Ide J, Bowman F, Simpson H, Posner J, Steinglass J. Abnormal reward circuitry in anorexia nervosa: A longitudinal, multimodal MRI study. Human Brain Mapping 2016, 37: 3835-3846. PMID: 27273474, PMCID: PMC5448464, DOI: 10.1002/hbm.23279.Peer-Reviewed Original ResearchConceptsAnorexia nervosaWeight restorationResting-state functional MRI scansStructural connectivityInpatient weight restorationFunctional MRI scansHum Brain MappUnderweight phaseUnderweight stateWhite matter anisotropyHealthy controlsUnderweight individualsFemale inpatientsAltered connectionsMRI scansFunctional connectivityDisorder symptomsEffective connectivityIllnessReward processingEffect sizeSame timeframeInpatientsPathophysiologySymptomsDissociable Fronto-Operculum-Insula Control Signals for Anticipation and Detection of Inhibitory Sensory Cue.
Cai W, Chen T, Ide JS, Li CR, Menon V. Dissociable Fronto-Operculum-Insula Control Signals for Anticipation and Detection of Inhibitory Sensory Cue. Cerebral Cortex 2016, 27: 4073-4082. PMID: 27473319, PMCID: PMC6059112, DOI: 10.1093/cercor/bhw219.Peer-Reviewed Original ResearchConceptsInhibitory cuesInhibitory controlIndependent functional magnetic resonanceSensory cortexCausal influenceInferior frontal cortexMultiple sensory modalitiesFunctional magnetic resonanceAnterior insular cortexDynamic causal interactionsStrong causal influencesCue anticipationPrimary sensory cortexPrepotent responsesSalient stimuliSalient cuesSensory modalitiesTrial changesSensory cuesAdaptive behaviorCuesRight frontoRIFCExternal cuesHigher anticipationClinically Anxious Individuals Show Disrupted Feedback between Inferior Frontal Gyrus and Prefrontal-Limbic Control Circuit
Cha J, DeDora D, Nedic S, Ide J, Greenberg T, Hajcak G, Mujica-Parodi L. Clinically Anxious Individuals Show Disrupted Feedback between Inferior Frontal Gyrus and Prefrontal-Limbic Control Circuit. Journal Of Neuroscience 2016, 36: 4708-4718. PMID: 27122030, PMCID: PMC6601720, DOI: 10.1523/jneurosci.1092-15.2016.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusVentromedial prefrontal cortexFrontal gyrusPrefrontal-limbic regionsAnxious individualsStimulus meaningNeurobiological responsesPrefrontal cortexFear generalization taskPrefrontal-limbic circuitsPrefrontal-limbic connectivityEmotion regulationAffective neurosciencePrefrontal-limbic systemGeneralization taskPerceptual similaritySimilarity gradientsPrefrontal regionsFMRI studyClinical anxietyAnxiety spectrumAnxiety severityVmPFCFunctional connectivityGyrus
2015
Using network dynamic fMRI for detection of epileptogenic foci
Nedic S, Stufflebeam S, Rondinoni C, Velasco T, dos Santos A, Leite J, Gargaro A, Mujica-Parodi L, Ide J. Using network dynamic fMRI for detection of epileptogenic foci. BMC Neurology 2015, 15: 262. PMID: 26689596, PMCID: PMC4687299, DOI: 10.1186/s12883-015-0514-y.Peer-Reviewed Original ResearchConceptsEpileptogenic focusHealthy controlsTemporal lobe epilepsy patientsCohort of patientsDuration of epilepsyVoxel functional connectivity analysisIntracranial EEG studiesPrevalent neurological disordersFunctional MRI methodsResting-state fMRIIpsilateral temporal poleFunctional connectivity analysisEpilepsy durationSuccessful surgeryEpileptogenic zoneFocal epilepsySeizure initiationEpilepsy patientsInterictal dischargesPatientsEpileptic regionsTemporal poleNeurological disordersFunctional connectivityImpaired memoryAnticipating conflict: Neural correlates of a Bayesian belief and its motor consequence
Hu S, Ide JS, Zhang S, Li CS. Anticipating conflict: Neural correlates of a Bayesian belief and its motor consequence. NeuroImage 2015, 119: 286-295. PMID: 26095091, PMCID: PMC4564311, DOI: 10.1016/j.neuroimage.2015.06.032.Peer-Reviewed Original ResearchConceptsProactive controlMedial prefrontal cortexNeural correlatesPrefrontal cortexPre-supplementary motor areaTrial reaction timeStop-signal taskBilateral anterior insulaProlonged response timeReaction timeMotor consequencesCognitive controlConflict anticipationRT slowingSignal taskAnterior insulaTarget onsetLarge fMRI data setsPrediction errorBehavioral paradigmsBehavioral consequencesGranger causality analysisFMRI data setsBayesian beliefFMRI signalsConflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task
Hu S, Ide JS, Zhang S, Sinha R, Li CS. Conflict anticipation in alcohol dependence — A model-based fMRI study of stop signal task. NeuroImage Clinical 2015, 8: 39-50. PMID: 26106526, PMCID: PMC4473266, DOI: 10.1016/j.nicl.2015.03.008.Peer-Reviewed Original ResearchConceptsStop-signal reaction timeHealthy control individualsConflict anticipationAlcohol dependenceCognitive controlProactive controlSignal taskSequential effectsModel-based fMRI studyAlcohol consumptionStop signalPre-supplementary motor areaBilateral inferior parietal cortexPerigenual anterior cingulate cortexSignificant sequential effectInferior parietal cortexSignal reaction timeWhole-brain responsesAnterior cingulate cortexRecent alcohol consumptionNeural correlatesFMRI studyNeural markersMotor areaTrial onset
2013
Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study
Chao HH, Hu S, Ide JS, Uchio E, Zhang S, Rose M, Concato J, Li CS. Effects of Androgen Deprivation on Cerebral Morphometry in Prostate Cancer Patients – An Exploratory Study. PLOS ONE 2013, 8: e72032. PMID: 23977199, PMCID: PMC3747074, DOI: 10.1371/journal.pone.0072032.Peer-Reviewed Original ResearchConceptsAndrogen deprivation therapyProstate cancer patientsGray matter volumeMagnetic resonance imagingPrimary motor cortexCancer patientsVoxel-based morphometryMatter volumeMotor cortexProstate cancerEffects of ADTLow-risk prostate cancerCerebral gray matter volumeStatistical Parametric Mapping 8Utility of brainControl participantsHigh-resolution magnetic resonance imagingPotential side effectsQuality of lifeResolution magnetic resonance imagingSame time pointsFunctional magnetic resonance imagingHigh-resolution T1Prefrontal cortical activationDorsolateral prefrontal cortexChanges in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control
Hu S, Chao H, Zhang S, Ide JS, Li CS. Changes in cerebral morphometry and amplitude of low-frequency fluctuations of BOLD signals during healthy aging: correlation with inhibitory control. Brain Structure And Function 2013, 219: 983-994. PMID: 23553547, PMCID: PMC3760988, DOI: 10.1007/s00429-013-0548-0.Peer-Reviewed Original ResearchConceptsDorsal lateral prefrontal cortexInferior parietal lobuleSupplementary motor areaFrontal regionsInhibitory controlCingulate cortexStop-signal reaction timeBilateral dorsal lateral prefrontal cortexGM volumeCognitive performance decreasesRight inferior parietal lobuleLow-frequency fluctuationsLateral prefrontal cortexSignal reaction timePosterior cingulate cortexAnterior cingulate cortexBlood oxygenation level-dependent (BOLD) signalLevel-dependent signalFamily-wise errorGray matter volumeRecent alcohol useCognitive challengesParietal lobuleSpontaneous neural activityVoxel-based morphometry
2012
Characterization of dual effects induced by antimicrobial peptides: Regulated cell death or membrane disruption
Paredes-Gamero E, Martins M, Cappabianco F, Ide J, Miranda A. Characterization of dual effects induced by antimicrobial peptides: Regulated cell death or membrane disruption. Biochimica Et Biophysica Acta 2012, 1820: 1062-1072. PMID: 22425533, DOI: 10.1016/j.bbagen.2012.02.015.Peer-Reviewed Original Research
2011
Resting-State Functional Connectivity of the Medial Superior Frontal Cortex
Zhang S, Ide JS, Li CS. Resting-State Functional Connectivity of the Medial Superior Frontal Cortex. Cerebral Cortex 2011, 22: 99-111. PMID: 21572088, PMCID: PMC3236794, DOI: 10.1093/cercor/bhr088.Peer-Reviewed Original ResearchConceptsMedial superior frontal cortexSupplementary motor areaSuperior frontal cortexFunctional connectivityFrontal cortexMotor areaResting-state functional magnetic resonanceResting-state functional connectivityFrontal cortical functionPresupplementary motor areaFunctional magnetic resonanceSubthalamic nucleusSomatomotor areasCortical functionPreSMAAnterior partSignificant hemispheric asymmetryCaudateBehavioral tasksAnatomical boundariesCortexFuture studiesHemispheric asymmetryMagnetic resonanceSeed region
2010
Dissociable Processes of Cognitive Control during Error and Non-Error Conflicts: A Study of the Stop Signal Task
Hendrick OM, Ide JS, Luo X, Li CS. Dissociable Processes of Cognitive Control during Error and Non-Error Conflicts: A Study of the Stop Signal Task. PLOS ONE 2010, 5: e13155. PMID: 20949134, PMCID: PMC2950843, DOI: 10.1371/journal.pone.0013155.Peer-Reviewed Original ResearchIncreased error-related thalamic activity during early compared to late cocaine abstinence
Li CS, Luo X, Sinha R, Rounsaville BJ, Carroll KM, Malison RT, Ding YS, Zhang S, Ide JS. Increased error-related thalamic activity during early compared to late cocaine abstinence. Drug And Alcohol Dependence 2010, 109: 181-189. PMID: 20163923, PMCID: PMC2875333, DOI: 10.1016/j.drugalcdep.2010.01.008.Peer-Reviewed Original Research
2009
Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition
Duann JR, Ide JS, Luo X, Li CS. Functional Connectivity Delineates Distinct Roles of the Inferior Frontal Cortex and Presupplementary Motor Area in Stop Signal Inhibition. Journal Of Neuroscience 2009, 29: 10171-10179. PMID: 19675251, PMCID: PMC2769086, DOI: 10.1523/jneurosci.1300-09.2009.Peer-Reviewed Original ResearchConceptsMotor response inhibitionBasal ganglia circuitryPresupplementary motor areaInferior prefrontal cortexStop-signal inhibitionMotor areaRight inferior prefrontal cortexPrefrontal cortexResponse inhibitionSignal inhibitionRecent imaging literaturePrimary motor cortexMedial prefrontal cortexInferior frontal cortexMotor cortexFrontal cortexCortical areasPrimary siteVentral attention systemPreSMAGreater effective connectivityCortexFunctional interconnectivityPsychophysiological interactionGo trials