2024
Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts
Rivier C, Acosta J, Leasure A, Forman R, Sharma R, de Havenon A, Spatz E, Inzucchi S, Kernan W, Falcone G, Sheth K. Secondary Prevention in Patients With Stroke Versus Myocardial Infarction: Analysis of 2 National Cohorts. Journal Of The American Heart Association 2024, 13: e033322. PMID: 38639369, PMCID: PMC11179946, DOI: 10.1161/jaha.123.033322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureCross-Sectional StudiesFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPractice Guidelines as TopicRisk AssessmentRisk FactorsSecondary PreventionStrokeUnited KingdomUnited StatesConceptsMyocardial infarctionPrevention scoreSecondary preventionImplementation of preventive therapyNational cohortUK BiobankAntiplatelet therapy useGuideline-directed therapyPrevention profilesBlood pressure controlAdherence to guideline-directed therapyLow-density lipoprotein controlNeighborhood deprivation levelHistory of strokeVascular risk profileStatin useAntiplatelet useTherapy usePreventive therapyComparison to participantsPrevention criteriaCross-sectional analysisBlood pressurePatientsPressure control
2021
Association of lichen planus with cardiovascular disease: A combined analysis of the UK Biobank and All of Us Study
Leasure AC, Acosta JN, Sansing LH, Sheth KN, Cohen JM, Falcone GJ. Association of lichen planus with cardiovascular disease: A combined analysis of the UK Biobank and All of Us Study. Journal Of The American Academy Of Dermatology 2021, 87: 454-456. PMID: 34562549, DOI: 10.1016/j.jaad.2021.09.030.Peer-Reviewed Original ResearchGenetically Determined Smoking Behavior and Risk of Nontraumatic Subarachnoid Hemorrhage
Acosta JN, Szejko N, Both CP, Vanent K, Noche RB, Gill TM, Matouk CC, Sheth KN, Gunel M, Falcone GJ. Genetically Determined Smoking Behavior and Risk of Nontraumatic Subarachnoid Hemorrhage. Stroke 2021, 52: 582-587. PMID: 33440997, PMCID: PMC7856108, DOI: 10.1161/strokeaha.120.031622.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDatabases, FactualElectronic Health RecordsFemaleGenetic Predisposition to DiseaseGenetic VariationHumansIntracranial AneurysmMaleMendelian Randomization AnalysisMiddle AgedMultifactorial InheritanceOdds RatioRisk AssessmentSelf ReportSmokingStrokeSubarachnoid HemorrhageTreatment OutcomeUnited Kingdom
2015
Epidemiology of multiple sclerosis: results from a large observational study in the UK
Jick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Epidemiology of multiple sclerosis: results from a large observational study in the UK. Journal Of Neurology 2015, 262: 2033-2041. PMID: 26067217, PMCID: PMC4768220, DOI: 10.1007/s00415-015-7796-2.Peer-Reviewed Original ResearchConceptsUnderlying autoimmune processHazard ratioCause mortalityAutoimmune processMS patientsUK Clinical Practice Research DatalinkClinical Practice Research DatalinkIncident MS casesAdjusted hazard ratioUrinary tract infectionCox proportional regressionMultiple sclerosis progressionPrimary care dataConfidence intervalsLarge observational studiesIdentification of predictorsOriginal medical recordsCurrent smokingPatient comorbiditiesTract infectionsFrequent comorbiditiesLifestyle factorsMS diagnosisMultiple sclerosisPatient group
2014
Mortality of patients with multiple sclerosis: a cohort study in UK primary care
Jick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Mortality of patients with multiple sclerosis: a cohort study in UK primary care. Journal Of Neurology 2014, 261: 1508-1517. PMID: 24838537, PMCID: PMC4119255, DOI: 10.1007/s00415-014-7370-3.Peer-Reviewed Original ResearchConceptsCause of deathMS patientsCause mortalityHazard ratioMS casesUK General Practice Research DatabaseGeneral Practice Research DatabaseLarge population-based cohortFirst MS diagnosisMortality of patientsFemale MS patientsCox proportional regressionMultiple sclerosis patientsPopulation-based cohortUK primary careConfidence intervalsDifferent hazard ratiosHR 1.7Index dateCohort studyYounger patientsHigher proportionSclerosis patientsMS diagnosisMultiple sclerosis