2024
Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk
Marini S, Kimball T, Mayerhofer E, Tack R, Senff J, Prapiadou S, Rivier C, Duskin J, Kourkoulis C, Falcone G, Yechoor N, Tanzi R, Rosand J, Singh S, Parodi L, Anderson C. Health-Related Behaviors and Risk of Common Age-Related Brain Diseases Across Severities of Genetic Risk. Neurology 2024, 103: e210014. PMID: 39504504, DOI: 10.1212/wnl.0000000000210014.Peer-Reviewed Original ResearchConceptsLate-life depressionGenetic riskDementia riskUK Biobank (UKBEffects of healthy lifestylesHealth-related behaviorsGenetic predispositionElevated genetic riskProspective cohort studyHazard of strokeCox proportional hazards modelsAge-related brain diseasesLifestyle behaviorsCare scoresUKB participantsProportional hazards modelHealthy lifestyleIncidence of strokeMultivariate Cox proportional hazards modelPolygenic scoresTargeted interventionsLifestyle adjustmentsAggregate risk estimatesRisk estimatesCohort studyLife's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults
Clocchiatti-Tuozzo S, Rivier C, Renedo D, Huo S, Hawkes M, de Havenon A, Schwamm L, Sheth K, Gill T, Falcone G. Life's Essential 8 and Poor Brain Health Outcomes in Middle-Aged Adults. Neurology 2024, 103: e209990. PMID: 39442069, PMCID: PMC11498939, DOI: 10.1212/wnl.0000000000209990.Peer-Reviewed Original ResearchConceptsLife's Essential 8Poor cardiovascular healthCardiovascular healthBrain healthLife's Essential 8 scoreUnadjusted riskEssential 8Determinants of cardiovascular healthUK Biobank (UKBCardiovascular health profileModifiable cardiovascular risk factorsBrain health outcomesRisk factorsComposite outcomePublic health constructsPopulation studiesMiddle-aged adultsCox modelLate-life depressionCox proportional hazards modelsBrain health benefitsMultivariate Cox modelCardiovascular risk factorsFollow-up timeAoU participants
2023
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDementiaHumansMagnetic Resonance ImagingMiddle AgedNeuroimagingProspective StudiesSleep DurationStrokeWhite MatterConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRetrospective StudiesWhite MatterConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexEmergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa
Ammar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.Peer-Reviewed Original ResearchConceptsAndexanet alfaExtra-axial hemorrhageEVD placementThrombotic eventsNew hemorrhagePrimary safety outcomeExternal ventricular drain placementLarge prospective studiesIntensive care unitIntracerebral hemorrhage patientsVentricular drain placementBolus patientsHospital lengthHospital LOSICU LOSTract hemorrhageRankin scoreSecondary outcomesAdult patientsBolus groupPrimary outcomeCare unitIntracerebral hemorrhageLong administration timeHemorrhage patients
2022
Bedside detection of intracranial midline shift using portable magnetic resonance imaging
Sheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, RN AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Scientific Reports 2022, 12: 67. PMID: 34996970, PMCID: PMC8742125, DOI: 10.1038/s41598-021-03892-7.Peer-Reviewed Original ResearchConceptsMidline shiftNeuroscience intensive care unitCare measurementYale-New Haven HospitalValuable bedside toolIntensive care unitPoor clinical outcomeBrain-injured patientsMass effectNew Haven HospitalMagnetic resonance imagingClinical outcomesIll patientsCare unitStroke patientsFunctional outcomeBedside toolObservational studyBedside detectionImaging examsPatientsResonance imagingPortable MRIImaging suiteSignificant concordance
2020
A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage
Murthy SB, Cho SM, Gupta A, Shoamanesh A, Navi BB, Avadhani R, Gruber J, Li Y, Greige T, Lioutas VA, Norton C, Zhang C, Mandava P, Iadecola C, Falcone GJ, Sheth KN, Biffi A, Rosand J, Qureshi AI, Goldstein JN, Kidwell C, Awad I, Selim M, Hanley DF, Woo D, Kamel H, Ziai WC. A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage. JAMA Neurology 2020, 77: 1390-1397. PMID: 32687564, PMCID: PMC7372494, DOI: 10.1001/jamaneurol.2020.2349.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imaging lesionsModified Rankin scoreDWI lesionsImaging lesionsAcute intracerebral hemorrhageIntracerebral hemorrhageFunctional outcomeSubgroup analysisChronic cerebral small vessel diseaseAdmission systolic blood pressureCerebral small vessel diseaseMulticenter prospective studySystolic blood pressurePoor functional outcomeSmall vessel diseaseDeep intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataMixed-effects logistic regressionMixed effects regression modelsAcute sequelaeHypertensive vasculopathyRankin scoreSecondary outcomesBlood pressureFixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke
Petersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51: 914-921. PMID: 32078493, PMCID: PMC7050651, DOI: 10.1161/strokeaha.119.026596.Peer-Reviewed Original ResearchConceptsSystolic BP thresholdMean arterial pressureArterial pressureEndovascular thrombectomyIschemic strokeSystolic BPFunctional outcomePercent timeFurther brain injuryModified Rankin ScaleBlood pressure changesPoor functional outcomeBP thresholdAutoregulatory indexHemorrhagic transformationMechanical thrombectomyRankin ScaleBlood pressureBP targetsHemodynamic managementAcute phaseBP managementStroke patientsCerebral autoregulationWorse outcomesRace/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage.
Miyares LC, Falcone GJ, Leasure A, Adeoye O, Shi FD, Kittner SJ, Langefeld C, Vagal A, Sheth KN, Woo D. Race/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage. Neurology 2020, 94: e1271-e1280. PMID: 31969467, PMCID: PMC7274930, DOI: 10.1212/wnl.0000000000008930.Peer-Reviewed Original ResearchConceptsSupratentorial intracerebral hemorrhageModified Rankin ScaleIntracerebral hemorrhageRace/ethnicityFunctional outcomeYounger patientsPoor outcomeAdmission Glasgow Coma Scale scoreEthnic/Racial VariationsGlasgow Coma Scale scoreHispanic participantsHispanic race/ethnicityAdmission blood pressureDeep ICH locationIntracerebral Hemorrhage (ERICH) studyProspective multicenter studyGood functional outcomeNon-Hispanic blacksBaseline disabilityRankin ScaleBlood pressureICH locationIntraventricular extensionMulticenter studyICH volume
2018
Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage
Ormseth CH, Falcone GJ, Jasak SD, Mampre DM, Leasure AC, Miyares LC, Hwang DY, James ML, Testai FD, Becker KJ, Tirschwell DL, Langefeld CD, Woo D, Sheth KN. Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage. Neurocritical Care 2018, 29: 419-425. PMID: 29949003, PMCID: PMC6286261, DOI: 10.1007/s12028-018-0554-4.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageHematoma volumeAdmission Glasgow Coma ScaleEthnic/Racial VariationsNon-traumatic intracerebral hemorrhageIntracerebral Hemorrhage (ERICH) studyProspective cohort studyGlasgow Coma ScaleIntensive care unitWithdrawal of careSpontaneous intracerebral hemorrhageSimilar mortality ratesLogistic regression analysisRace/ethnicity modifiesRace/ethnicityCMO patientsHospital mortalityCohort studyRankin ScaleWhite patientsComa ScaleBlack patientsCare unitEndotracheal intubationICH patients
2016
Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria
Leslie-Mazwi TM, Hirsch JA, Falcone GJ, Schaefer PW, Lev MH, Rabinov JD, Rost NS, Schwamm L, González RG. Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria. JAMA Neurology 2016, 73: 1-7. PMID: 26524074, DOI: 10.1001/jamaneurol.2015.3000.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSelection of patientsClinical criteriaFavorable outcomeSuccessful reperfusionMRS scoreLTB patientsIschemic strokeTerminal internal carotid artery occlusionResonance imagingInternal carotid artery occlusionStroke treatment outcomesEndovascular stroke treatmentAcute ischemic strokeCarotid artery occlusionProspective cohort studyMiddle cerebral arterySpecific magnetic resonance imagingInfarct volume determinationArtery occlusionCohort studyStroke treatmentCerebral arteryEndovascular treatmentPatient selection
2014
APOE &egr; variants increase risk of warfarin-related intracerebral hemorrhage
Falcone GJ, Radmanesh F, Brouwers HB, Battey TW, Devan WJ, Valant V, Raffeld MR, Chitsike LP, Ayres AM, Schwab K, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Flaherty ML, Martini SR, Deka R, Biffi A, Kraft P, Woo D, Rosand J, Anderson CD. APOE &egr; variants increase risk of warfarin-related intracerebral hemorrhage. Neurology 2014, 83: 1139-1146. PMID: 25150286, PMCID: PMC4176027, DOI: 10.1212/wnl.0000000000000816.Peer-Reviewed Original ResearchMeSH KeywordsApolipoprotein E2Case-Control StudiesCerebral HemorrhageGenetic Predisposition to DiseaseGenotypeHumansProspective StudiesRiskWarfarinPredicting Hematoma Expansion After Primary Intracerebral Hemorrhage
Brouwers HB, Chang Y, Falcone GJ, Cai X, Ayres AM, Battey TW, Vashkevich A, McNamara KA, Valant V, Schwab K, Orzell SC, Bresette LM, Feske SK, Rost NS, Romero JM, Viswanathan A, Chou S, Greenberg SM, Rosand J, Goldstein JN. Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage. JAMA Neurology 2014, 71: 158-164. PMID: 24366060, PMCID: PMC4131760, DOI: 10.1001/jamaneurol.2013.5433.Peer-Reviewed Original ResearchConceptsPrimary intracerebral hemorrhageIndependent validation cohortIntracerebral hemorrhageHematoma expansionValidation cohortHigh riskPrediction scoreUrban academic medical centerBaseline ICH volumeWarfarin sodium useProspective cohort studyAcute intracerebral hemorrhageMultivariable logistic regressionTomography angiography spot signComputed tomography angiography spot signAcademic medical centerPredictors of expansionCohort studyMultivariable analysisDevelopment cohortICH volumeC-statisticClinical trialsIndividualized treatmentMAIN OUTCOMEAccuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data
Radmanesh F, Devan WJ, Anderson CD, Rosand J, Falcone GJ. Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data. European Journal Of Human Genetics 2014, 22: 1239-1242. PMID: 24448547, PMCID: PMC4169533, DOI: 10.1038/ejhg.2013.308.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAlzheimer DiseaseApolipoproteins ECase-Control StudiesCerebral HemorrhageGene FrequencyGenome, HumanGenome-Wide Association StudyGenotypeGenotyping TechniquesHapMap ProjectHumansLogistic ModelsLongitudinal StudiesPolymorphism, Single NucleotidePrincipal Component AnalysisProspective StudiesQuality ControlWhite PeopleConceptsIntracerebral hemorrhageAlzheimer's diseaseSingle nucleotide polymorphismsEpsilon allelesAPOE epsilon allelesCerebral amyloid angiopathyLate-onset Alzheimer's diseaseCatabolism of chylomicronsLow-density lipoproteinGenetic risk factorsAmyloid angiopathyCommon single nucleotide polymorphismsRisk factorsApolipoprotein EDensity lipoproteinControl groupMain apoproteinApoEDiseaseGenome-wide genotyping dataEuropean ancestryImproved balanceHapMap reference panelsGenome-wide genotyping arraysAlleles
2013
Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage
Woo D, Deka R, Falcone GJ, Flaherty ML, Haverbusch M, Martini SR, Greenberg SM, Ayres AM, Sauerbeck L, Kissela BM, Kleindorfer DO, Moomaw CJ, Anderson CD, Broderick JP, Rosand J, Langefeld CD, Woo JG. Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage. Stroke 2013, 44: 3013-3017. PMID: 24008570, PMCID: PMC3873717, DOI: 10.1161/strokeaha.113.001304.Peer-Reviewed Original ResearchConceptsRisk of ICHLobar intracerebral hemorrhageStatin useIntracerebral hemorrhageReplication cohortICH casesAssociation of hypercholesterolemiaHemorrhagic Stroke studyNonlobar intracerebral hemorrhageCase-control studyApolipoprotein E genotypeFisher's exact testEnvironmental risk factorsBreslow-Day testHemorrhagic strokeStroke StudyRisk factorsClinical changesE4 genotypeAPOE polymorphismE genotypeApolipoprotein EDiscovery cohortHigh riskLower riskPredictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage
Falcone GJ, Biffi A, Brouwers HB, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Predictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage. JAMA Neurology 2013, 70: 988-994. PMID: 23733000, PMCID: PMC3808840, DOI: 10.1001/jamaneurol.2013.98.Peer-Reviewed Original ResearchConceptsLobar intracerebral hemorrhageIntensity of anticoagulationIntracerebral hemorrhageICH volumeHematoma volumeIndependent predictorsLobar supratentorial intracerebral haemorrhageProspective cohort studyCoronary artery diseaseSupratentorial intracerebral hemorrhageMedian ICH volumePrimary ICH patientsComputed tomography scanMultivariable linear regressionAcademic medical centerIntracerebral hemorrhage volumeLobar hemorrhageAntiplatelet treatmentRadiological outcomesArtery diseaseCohort studyDeep hemorrhagesICH locationICH patientsMale sexMagnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies
Fondell E, O’Reilly É, Fitzgerald KC, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Magnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2013, 14: 356-361. PMID: 23777266, PMCID: PMC3743429, DOI: 10.3109/21678421.2013.803577.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisMagnesium intakeALS riskCohort studyLateral sclerosisCases of ALSLarge prospective cohort studyProspective cohort studyDietary magnesium intakeLow magnesium intakeCase-control studyLarge cohort studyProportional hazards modelCohort-specific estimatesRandom-effects modelProspective studyHighest quintileDietary intakeProtective effectHazards modelIntakeMagnesium absorptionSclerosisHeavy metal exposureRiskIntakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies
Fitzgerald KC, O'Reilly ÉJ, Fondell E, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies. Annals Of Neurology 2013, 73: 236-245. PMID: 23362045, PMCID: PMC3608702, DOI: 10.1002/ana.23820.Peer-Reviewed Original ResearchConceptsRisk of ALSAmyotrophic lateral sclerosisNurses' Health StudyRisk ratioALS deathsVitamin CLateral sclerosisHealth StudyCancer Prevention Study II Nutrition CohortCox proportional hazards regressionMultivariate risk ratiosRetired Persons DietHealth Professionals FollowVitamin C intakeNational Death IndexProportional hazards regressionHigh dietary intakeRandom-effects methodNutrition CohortProfessionals FollowCohort studyProspective cohortC intakeDeath IndexHazards regressionBurden of Blood Pressure–Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage
Falcone GJ, Biffi A, Devan WJ, Brouwers HB, Anderson CD, Valant V, Ayres AM, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Rosand J. Burden of Blood Pressure–Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage. Stroke 2013, 44: 321-326. PMID: 23321443, PMCID: PMC3560332, DOI: 10.1161/strokeaha.112.675181.Peer-Reviewed Original ResearchConceptsPoor clinical outcomeBaseline hematoma volumeIntracerebral hemorrhageClinical outcomesHematoma volumeGenetic risk scoreBlood pressureICH volumeRisk scoreHypertension-related end-organ damageRisk of ICHAdmission ICH volumeEnd-organ damageLarger hematoma volumeSupratentorial intracerebral hemorrhageHigh blood pressureCerebral small vesselsDeep intracerebral hemorrhageSmall vesselsSingle nucleotide polymorphismsMultivariate regression analysisProgressive diseaseProspective studyAcute manifestationsWorse outcomes
2012
Premorbid body mass index and risk of amyotrophic lateral sclerosis
O'Reilly ÉJ, Wang H, Weisskopf MG, Fitzgerald KC, Falcone G, McCullough ML, Thun M, Park Y, Kolonel LN, Ascherio A. Premorbid body mass index and risk of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2012, 14: 205-211. PMID: 23134505, PMCID: PMC3615420, DOI: 10.3109/21678421.2012.735240.Peer-Reviewed Original ResearchConceptsBody mass indexHealthy body mass indexPremorbid body mass indexALS ratesMass indexCohort-specific Cox proportional hazard modelsLower premorbid Body Mass IndexLower body mass indexCox proportional hazards modelAmyotrophic lateral sclerosis riskProportional hazards modelAmyotrophic lateral sclerosisRandom-effects modelOngoing cohortUnhealthy weightLateral sclerosisHazards modelUndiagnosed diseaseCurrent weightWeight lossObeseALSAssociationMalesFemales