2024
Connectomic reconstruction predicts visual features used for navigation
Garner D, Kind E, Lai J, Nern A, Zhao A, Houghton L, Sancer G, Wolff T, Rubin G, Wernet M, Kim S. Connectomic reconstruction predicts visual features used for navigation. Nature 2024, 634: 181-190. PMID: 39358517, PMCID: PMC11446847, DOI: 10.1038/s41586-024-07967-z.Peer-Reviewed Original ResearchConceptsVisual featuresAnterior visual pathwayClasses of neuronsOptic lobeAnterior optic tubercleLocation of synapsesER neuronsDrosophila melanogasterOptic tubercleAVPPresynaptic connectionsVisual informationCentral brainNeuronsConnectome reconstructionVisual pathwayNavigation systemCentral complexPostsynaptic connectionsMedullaNeural classInformation channelsDendritic fieldsNavigationVisual inputNeuronal parts list and wiring diagram for a visual system
Matsliah A, Yu S, Kruk K, Bland D, Burke A, Gager J, Hebditch J, Silverman B, Willie K, Willie R, Sorek M, Sterling A, Kind E, Garner D, Sancer G, Wernet M, Kim S, Murthy M, Seung H. Neuronal parts list and wiring diagram for a visual system. Nature 2024, 634: 166-180. PMID: 39358525, PMCID: PMC11446827, DOI: 10.1038/s41586-024-07981-1.Peer-Reviewed Original Research
2023
Generation of ventralized human thalamic organoids with thalamic reticular nucleus
Kiral F, Cakir B, Tanaka Y, Kim J, Yang W, Wehbe F, Kang Y, Zhong M, Sancer G, Lee S, Xiang Y, Park I. Generation of ventralized human thalamic organoids with thalamic reticular nucleus. Cell Stem Cell 2023, 30: 677-688.e5. PMID: 37019105, PMCID: PMC10329908, DOI: 10.1016/j.stem.2023.03.007.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsSingle-cell RNA sequencingReceptor tyrosine protein kinaseTyrosine protein kinaseEmbryonic stem cellsDisease-associated genesLineage developmentRNA sequencingHuman brain developmentOrganoid systemsStem cellsHuman brain organoidsNeuronal functionBrain organoidsOrganoidsBrain organoid systemsDistinct nucleiBrain developmentThalamic developmentPTCHD1NucleusKinaseGenesSequencing
2021
Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila
Kind E, Longden K, Nern A, Zhao A, Sancer G, Flynn M, Laughland C, Gezahegn B, Ludwig H, Thomson A, Obrusnik T, Alarcón P, Dionne H, Bock D, Rubin G, Reiser M, Wernet M. Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila. ELife 2021, 10: e71858. PMID: 34913436, PMCID: PMC8789284, DOI: 10.7554/elife.71858.Peer-Reviewed Original ResearchThe development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster
Sancer G, Wernet M. The development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster. Arthropod Structure & Development 2021, 61: 101012. PMID: 33618155, DOI: 10.1016/j.asd.2020.101012.Peer-Reviewed Original ResearchConceptsDorsal rim areaOptic lobeSpecific cellular elementsCell typesMedulla neuropilPhotoreceptor terminalsNeuronal subtypesRim areaOmmatidial subtypesDistinct subtypesSynaptic connectionsNeural circuitsCellular elementsSubtypesDistal portionRetinal mosaicsMolecular mechanismsCell type-specific transcriptomicsResponse propertiesPhotoreceptorsLobeCellsR7 photoreceptorsR8 cellsR8 photoreceptors