2024
Connectomic reconstruction predicts visual features used for navigation
Garner D, Kind E, Lai J, Nern A, Zhao A, Houghton L, Sancer G, Wolff T, Rubin G, Wernet M, Kim S. Connectomic reconstruction predicts visual features used for navigation. Nature 2024, 634: 181-190. PMID: 39358517, PMCID: PMC11446847, DOI: 10.1038/s41586-024-07967-z.Peer-Reviewed Original ResearchConceptsVisual featuresAnterior visual pathwayClasses of neuronsOptic lobeAnterior optic tubercleLocation of synapsesER neuronsDrosophila melanogasterOptic tubercleAVPPresynaptic connectionsVisual informationCentral brainNeuronsConnectome reconstructionVisual pathwayNavigation systemCentral complexPostsynaptic connectionsMedullaNeural classInformation channelsDendritic fieldsNavigationVisual inputNeuronal parts list and wiring diagram for a visual system
Matsliah A, Yu S, Kruk K, Bland D, Burke A, Gager J, Hebditch J, Silverman B, Willie K, Willie R, Sorek M, Sterling A, Kind E, Garner D, Sancer G, Wernet M, Kim S, Murthy M, Seung H. Neuronal parts list and wiring diagram for a visual system. Nature 2024, 634: 166-180. PMID: 39358525, PMCID: PMC11446827, DOI: 10.1038/s41586-024-07981-1.Peer-Reviewed Original ResearchOlfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking
Takagi S, Sancer G, Abuin L, Stupski S, Roman Arguello J, Prieto-Godino L, Stern D, Cruchet S, Álvarez-Ocaña R, Wienecke C, van Breugel F, Jeanne J, Auer T, Benton R. Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking. Nature Communications 2024, 15: 7041. PMID: 39147786, PMCID: PMC11327376, DOI: 10.1038/s41467-024-50808-w.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsPopulation expansionSpecies-specific expansionSensory neuronsProjection neuronsConnections of sensory neuronsOlfactory sensory neuron numbersSpecies-specific behaviorsD. sechelliaDrosophila sechelliaEcologically-relevantProportion of neuronsEnvironmental cuesMultigenic changesEvolutionary expansionIncreased synaptic connectivityFunctional impactPN sensitivityNeuronal adaptationOdor trackingNeuronsSechelliaLateral inhibitionInhibitionSpecies
2021
Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila
Kind E, Longden K, Nern A, Zhao A, Sancer G, Flynn M, Laughland C, Gezahegn B, Ludwig H, Thomson A, Obrusnik T, Alarcón P, Dionne H, Bock D, Rubin G, Reiser M, Wernet M. Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila. ELife 2021, 10: e71858. PMID: 34913436, PMCID: PMC8789284, DOI: 10.7554/elife.71858.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainColorDrosophila melanogasterFemaleMicroscopy, ElectronNeuronsPhotoreceptor Cells, InvertebrateSynapsesVisual PathwaysThe development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster
Sancer G, Wernet M. The development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster. Arthropod Structure & Development 2021, 61: 101012. PMID: 33618155, DOI: 10.1016/j.asd.2020.101012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrosophila melanogasterNeuronsOptic Lobe, NonmammalianPhotoreceptor Cells, InvertebrateSynapsesConceptsDorsal rim areaOptic lobeSpecific cellular elementsCell typesMedulla neuropilPhotoreceptor terminalsNeuronal subtypesRim areaOmmatidial subtypesDistinct subtypesSynaptic connectionsNeural circuitsCellular elementsSubtypesDistal portionRetinal mosaicsMolecular mechanismsCell type-specific transcriptomicsResponse propertiesPhotoreceptorsLobeCellsR7 photoreceptorsR8 cellsR8 photoreceptors
2019
Cellular and synaptic adaptations of neural circuits processing skylight polarization in the fly
Sancer G, Kind E, Uhlhorn J, Volkmann J, Hammacher J, Pham T, Plazaola-Sasieta H, Wernet M. Cellular and synaptic adaptations of neural circuits processing skylight polarization in the fly. Journal Of Comparative Physiology A 2019, 206: 233-246. PMID: 31811399, DOI: 10.1007/s00359-019-01389-3.Peer-Reviewed Original ResearchConceptsPolarization-sensitive photoreceptorsDorsal rim areaCell typesCentral brainCertain cell typesDrosophila melanogasterMedulla columnsLarge insectsSynaptic adaptationPhotoreceptors R7Downstream elementsDifferent speciesPost-synaptic membraneDRA regionFunctional roleComplex circuit architecturesInsectsPolarization visionDistal medullaLobula complexMedulla neuropilNeuronal elementsSpecialized ommatidiaOptic lobePhotoreceptorsModality-Specific Circuits for Skylight Orientation in the Fly Visual System
Sancer G, Kind E, Plazaola-Sasieta H, Balke J, Pham T, Hasan A, Münch L, Courgeon M, Mathejczyk T, Wernet M. Modality-Specific Circuits for Skylight Orientation in the Fly Visual System. Current Biology 2019, 29: 2812-2825.e4. PMID: 31402302, DOI: 10.1016/j.cub.2019.07.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDrosophila melanogasterOptic Lobe, NonmammalianOrientation, SpatialPhotoreceptor Cells, Invertebrate