Featured Publications
Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19
Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F, Biswas A, Ghazi L, Greenberg J, Mansour S, Moledina D, Wilson FP. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA Network Open 2021, 4: e211095. PMID: 33688965, PMCID: PMC7948062, DOI: 10.1001/jamanetworkopen.2021.1095.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overBlack or African AmericanCohort StudiesComorbidityCOVID-19CreatinineFemaleFollow-Up StudiesGlomerular Filtration RateHispanic or LatinoHumansHypertensionKidney Function TestsLongitudinal StudiesMaleMiddle AgedPatient DischargeProportional Hazards ModelsRenal Insufficiency, ChronicRetrospective StudiesSARS-CoV-2United StatesConceptsCOVID-19-associated acute kidney injuryAcute kidney injuryHospital acute kidney injurySubgroup of patientsKidney functionKidney injuryCohort studyHospital dischargeAKI recoveryKidney diseaseCOVID-19Peak creatinine levelsRetrospective cohort studyChronic kidney diseaseDays of dischargeHalf of patientsGlomerular filtration rateCoronavirus disease 2019AKI severityBaseline comorbiditiesEGFR decreaseDialysis requirementEGFR slopeKidney recoveryCreatinine levels
2023
Correlates of Spontaneous Blood Pressure Reduction Following Severe Inpatient Hypertension Development
Garg K, Staunton M, Peixoto A, Wilson F, Ghazi L. Correlates of Spontaneous Blood Pressure Reduction Following Severe Inpatient Hypertension Development. American Journal Of Hypertension 2023, 37: 273-279. PMID: 37988620, DOI: 10.1093/ajh/hpad112.Peer-Reviewed Original ResearchBlood pressure reductionSevere hypertensionBP reductionPressure reductionRetrospective cohort studyChronic pulmonary diseaseMultivariable logistic regressionFuture treatment decisionsAntihypertensive medicationsAntihypertensive therapyCohort studyHypertension developmentBP dropHospitalized patientsPulmonary diseaseTreatment guidelinesBP treatmentWorse outcomesTreatment decisionsCardiac arrythmiasPatientsPotassium levelsHigh potassium levelsLogistic regressionDemographic characteristicsOutcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI
Aklilu A, Kumar S, Yamamoto Y, Moledina D, Sinha F, Testani J, Wilson F. Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI. Kidney360 2023, 4: 1371-1381. PMID: 37644648, PMCID: PMC10615381, DOI: 10.34067/kid.0000000000000250.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHeart failure hospitalizationSodium-glucose cotransporter-2 inhibitor useSodium-glucose cotransporter 2 inhibitorsAcute heart failure hospitalizationCotransporter 2 inhibitorsCox regression analysisRenal recoveryFailure hospitalizationAKI diagnosisKidney injuryInhibitor useLower riskStage 5 chronic kidney diseaseTime-varying Cox regression analysisKidney Disease Improving Global OutcomesInverse probability-weighted analysisMulticenter retrospective cohort studyMultivariable Cox regression analysisStage 5 CKDAcute heart failureRetrospective cohort studyChronic kidney diseaseKidney function recoveryGlomerular filtration rateDifferences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19
Liu Y, Rajeevan H, Simonov M, Lee S, Wilson F, Desir G, Vinetz J, Yan X, Wang Z, Clark B, Possick J, Price C, Lutchmansingh D, Ortega H, Zaeh S, Gomez J, Cohn L, Gautam S, Chupp G. Differences in Mortality Among Patients With Asthma and COPD Hospitalized With COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2023, 11: 3383-3390.e3. PMID: 37454926, PMCID: PMC10787810, DOI: 10.1016/j.jaip.2023.07.006.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseType 2 inflammationCOVID-19 severitySOFA scoreAirway diseaseNoneosinophilic asthmaSequential Organ Failure Assessment scoreOrgan Failure Assessment scoreSevere coronavirus disease 2019Higher SOFA scoreMedian SOFA scoreRetrospective cohort studyObstructive pulmonary diseaseOdds of mortalityLower SOFA scoresCells/μLCOVID-19 outcomesCoronavirus disease 2019Logistic regression analysisCOVID-19Clinical confoundersAsthma patientsCohort studyImmunological factorsClinical features
2022
Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment
Ghazi L, Li F, Chen X, Simonov M, Yamamoto Y, Biswas A, Hanna J, Shah T, Townsend R, Peixoto A, Wilson FP. Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment. Journal Of Clinical Hypertension 2022, 24: 339-349. PMID: 35174627, PMCID: PMC8925013, DOI: 10.1111/jch.14431.Peer-Reviewed Original ResearchConceptsSevere hypertensionBlood pressure responseBP elevationUntreated patientsCox proportional hazards modelRetrospective cohort studyPressure responseProportional hazards modelAntihypertensive treatmentInpatient hypertensionMore comorbiditiesPossible overtreatmentHospitalized adultsCohort studyHypertension prevalenceArterial pressureHospitalized patientsTreatment guidelinesHypertensionGreater rateHazards modelPatientsAntihypertensivesTreatmentAdmission
2021
Predicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center study
Ghazi L, Simonov M, Mansour SG, Moledina DG, Greenberg JH, Yamamoto Y, Biswas A, Wilson FP. Predicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center study. PLOS ONE 2021, 16: e0251376. PMID: 33979353, PMCID: PMC8115794, DOI: 10.1371/journal.pone.0251376.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionHours of hospitalizationReceiver operator characteristicAdult patientsNegative SARS-CoV-2 testYale New Haven Health SystemLower white blood cell countAvailable electronic health record dataRetrospective multi-center studySARS-CoV-2 positivityWhite blood cell countSARS-CoV-2 testSARS-CoV-2 testingPositive COVID testHospitalized adult patientsRetrospective cohort studyPopulation of patientsElectronic health record dataBlood cell countVital sign abnormalitiesMulti-center studyFalse-negative testingHealth record dataSARS-CoV-2 virusSARS-CoV-2
2018
Enhancing the prediction of acute kidney injury risk after percutaneous coronary intervention using machine learning techniques: A retrospective cohort study
Huang C, Murugiah K, Mahajan S, Li SX, Dhruva SS, Haimovich JS, Wang Y, Schulz WL, Testani JM, Wilson FP, Mena CI, Masoudi FA, Rumsfeld JS, Spertus JA, Mortazavi BJ, Krumholz HM. Enhancing the prediction of acute kidney injury risk after percutaneous coronary intervention using machine learning techniques: A retrospective cohort study. PLOS Medicine 2018, 15: e1002703. PMID: 30481186, PMCID: PMC6258473, DOI: 10.1371/journal.pmed.1002703.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedClinical Decision-MakingData MiningDecision Support TechniquesFemaleHumansMachine LearningMaleMiddle AgedPercutaneous Coronary InterventionProtective FactorsRegistriesReproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionNational Cardiovascular Data RegistryRisk prediction modelAKI eventsAKI riskCoronary interventionAKI modelMean ageCardiology-National Cardiovascular Data RegistryAcute kidney injury riskAKI risk predictionRetrospective cohort studyIdentification of patientsCandidate variablesAvailable candidate variablesCohort studyPCI proceduresPoint of careBrier scoreAmerican CollegeData registryPatientsCalibration slopeInjury riskSame cohortAttributable Risk and Time Course of Colistin-Associated Acute Kidney Injury
Miano TA, Lautenbach E, Wilson FP, Guo W, Borovskiy Y, Hennessy S. Attributable Risk and Time Course of Colistin-Associated Acute Kidney Injury. Clinical Journal Of The American Society Of Nephrology 2018, 13: 542-550. PMID: 29545383, PMCID: PMC5969457, DOI: 10.2215/cjn.06980717.Peer-Reviewed Original ResearchConceptsBaseline hemoglobin concentrationAKI riskAttributable riskHours of exposureHemoglobin concentrationEquation Poisson regression modelsGlobal Outcomes creatinine criteriaIncidence of AKIAcute kidney injuryRetrospective cohort studyPropensity-matched pairsSimilar baseline characteristicsEarly treatment decisionsIncidence rate ratiosBroad-spectrum antibioticsHours of treatmentPoisson regression modelsColistin groupColistin toxicityHospital mortalityCreatinine criteriaKidney injuryBaseline characteristicsCohort studyKidney function
2017
Association of Alternative Approaches to Normalizing Peritoneal Dialysis Clearance with Mortality and Technique Failure: A Retrospective Analysis Using the United States Renal Data System-Dialysis Morbidity and Mortality Study, Wave 2
Boyle SM, Li Y, Wilson FP, Glickman JD, Feldman HI. Association of Alternative Approaches to Normalizing Peritoneal Dialysis Clearance with Mortality and Technique Failure: A Retrospective Analysis Using the United States Renal Data System-Dialysis Morbidity and Mortality Study, Wave 2. Advances In Peritoneal Dialysis 2017, 37: 85-93. PMID: 27680757, PMCID: PMC5448711, DOI: 10.3747/pdi.2015.00227.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood Urea NitrogenCause of DeathCohort StudiesCreatinineDialysis SolutionsFemaleHumansKaplan-Meier EstimateKidney Failure, ChronicKidney Function TestsMaleMiddle AgedPeritoneal Dialysis, Continuous AmbulatoryProportional Hazards ModelsRegistriesRenal DialysisRetrospective StudiesRisk AssessmentSurvival AnalysisUnited StatesUreaConceptsKt/body surface areaKt/VBody surface areaTechnique failureHarrell's C-statisticPeritoneal urea clearanceC-statisticHazard ratioUrea clearanceUrine volumeUnited States Renal Data System Dialysis MorbidityBody mass index strataMortality Study Wave 2Peritoneal Kt/VUnited States Renal Data SystemIncident peritoneal dialysis patientsIdeal weightSignificant differencesCox proportional hazards modelPeritoneal dialysis clearanceMedian patient ageRetrospective cohort studyPeritoneal dialysis patientsGlomerular filtration rateOutcomes of mortality
2013
The impact of documentation of severe acute kidney injury on mortality
Wilson FP, Bansal AD, Jasti SK, Lin JJ, Shashaty MG, Berns JS, Feldman HI, Fuchs BD. The impact of documentation of severe acute kidney injury on mortality. Clinical Nephrology 2013, 80: 417-425. PMID: 24075024, PMCID: PMC4018223, DOI: 10.5414/cn108072.Peer-Reviewed Original ResearchConceptsAcute kidney injuryBaseline creatinineKidney injuryHigher Sequential Organ Failure Assessment scoreDocumentation of AKIRecognition of AKISequential Organ Failure Assessment scoreAngiotensin receptor blocker medicationHospital acute kidney injuryOrgan Failure Assessment scoreSevere acute kidney injuryHigher baseline creatinineHigher peak creatinineRetrospective cohort studyImproved clinical outcomesUniversity Health SystemSeverity of diseaseNephrology consultationPeak creatinineRapid discontinuationCohort studyImproved survivalClinical outcomesIllness severityKidney disease