2024
Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder
Echevarria M, Batistuzzo M, Silva R, Brunoni A, Sato J, Miguel E, Hoexter M, Shavitt R. Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder. Journal Of Affective Disorders 2024, 355: 175-183. PMID: 38548207, DOI: 10.1016/j.jad.2024.03.141.Peer-Reviewed Original ResearchTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationCurrent stimulationActive transcranial direct current stimulationSensorimotor networkOCD symptom dimensionsTreatment-resistant obsessive-compulsive disorderNeurobiological mechanisms of actionObsessive-compulsive disorder pathophysiologyWhole-brain connectivity analysisDaily tDCS sessionsSymptom improvementResting-state functional MRITDCS sessionsNon-invasive neuromodulation interventionsBrain stimulation interventionsFunctional connectivity changesAssociated with connectivityLeft deltoidSymptom dimensionsNeurobiological mechanismsLeft precuneusMode networkPre/postcentral gyri
2015
Gamma knife surgery
Lopes A, Batistuzzo M, Gentil A, Hoexter M, Miguel E. Gamma knife surgery. 2015, 369-383. DOI: 10.1002/9781118801086.ch20.Peer-Reviewed Original ResearchSevere adverse eventsGamma Knife surgeryGamma knife radiosurgeryDeep brain stimulationAdverse eventsBrain cystsCase seriesDecreased incidenceObsessive-compulsive disorderSymptom improvementInternal capsuleKnife radiosurgeryAblative proceduresAnterior limbPsychiatric disordersBrain stimulationMajority of studiesRadiosurgical techniquesWhite matter tissueDisordersPatientsSurgeryLesionsRadiosurgeryIncidence
2014
Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial
Lopes A, Greenberg B, Canteras M, Batistuzzo M, Hoexter M, Gentil A, Pereira C, Joaquim M, de Mathis M, D’Alcante C, Taub A, de Castro D, Tokeshi L, Sampaio L, Leite C, Shavitt R, Diniz J, Busatto G, Norén G, Rasmussen S, Miguel E. Gamma Ventral Capsulotomy for Obsessive-Compulsive Disorder: A Randomized Clinical Trial. JAMA Psychiatry 2014, 71: 1066-1076. PMID: 25054836, DOI: 10.1001/jamapsychiatry.2014.1193.Peer-Reviewed Original ResearchConceptsIntractable obsessive-compulsive disorderObsessive-compulsive disorderClinical trialsGamma ventral capsulotomyClinical Global Impressions-Improvement scaleSerious adverse eventsRandomized clinical trialsCGI-I ratingsDeep brain stimulationYale-Brown ObsessiveAdverse eventsMonth 12Additional patientsActive treatmentSham groupSymptom improvementInternal capsuleSpecialized centersNeurosurgical ablationAnterior limbMAIN OUTCOMEPsychiatric disordersPatientsOCD symptom improvementSelect cases
2012
Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder
Hoexter M, Dougherty D, Shavitt R, D'Alcante C, Duran F, Lopes A, Diniz J, Batistuzzo M, Evans K, Bressan R, Busatto G, Miguel E. Differential prefrontal gray matter correlates of treatment response to fluoxetine or cognitive-behavioral therapy in obsessive–compulsive disorder. European Neuropsychopharmacology 2012, 23: 569-580. PMID: 22841131, DOI: 10.1016/j.euroneuro.2012.06.014.Peer-Reviewed Original ResearchConceptsGray matter volumeMedial prefrontal cortexCognitive behavioral therapyObsessive-compulsive disorderTreatment responseTreatment-naïve OCD patientsTreatment groupsMagnetic resonance imagingMatter volumeOrbitofrontal cortexLateral orbitofrontal cortexSymptom improvementOCD patientsFluoxetine treatment groupTrial of fluoxetineSerotonin reuptake inhibitorsAdequate therapeutic approachStructural magnetic resonance imagingCBT treatment groupRight medial prefrontal cortexGroup-based cognitive behavioral therapyRegional gray matter volumeStructural MRI scansDistinct brain regionsYale-Brown Obsessive