2024
GPT-based normative models of brain sMRI correlate with dimensional psychopathology
Mendes S, Pinaya W, Pan P, Gadelha A, Belangero S, Jackowski A, Rohde L, Miguel E, Sato J. GPT-based normative models of brain sMRI correlate with dimensional psychopathology. Imaging Neuroscience 2024, 2: 1-15. DOI: 10.1162/imag_a_00204.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderChild Behavior ChecklistDeficit hyperactivity disorderAutism spectrum disorderPsychiatric disordersBrain regionsStructural MRIDimensional psychopathologyHyperactivity disorderBrazilian High-Risk Cohort StudyAttention deficit hyperactivity disorder scoresAutism Brain Imaging Data Exchange IIAdolescent Brain Cognitive DevelopmentChild Behavior Checklist scalesHigh Risk Cohort StudyDetect psychiatric symptomsEmergent psychiatric disordersBrain structural MRINeurobiological substratesNeuroimaging studiesLanguage tasksPsychiatric symptomsBehavior ChecklistPsychiatric conditionsSpectrum disorder
2023
Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample
Sato J, Biazoli C, Bueno A, Caye A, Pan P, Santoro M, Honorato‐Mauer J, Salum G, Hoexter M, Bressan R, Jackowski A, Miguel E, Belangero S, Rohde L. Polygenic risk score for attention‐deficit/hyperactivity disorder and brain functional networks segregation in a community‐based sample. Genes Brain & Behavior 2023, 22: e12838. PMID: 36811275, PMCID: PMC10067387, DOI: 10.1111/gbb.12838.Peer-Reviewed Original ResearchConceptsCingulo-opercular networkDefault mode networkADHD-PRSAttentional networksFunctional segregationAttention-deficit/hyperactivity disorder (ADHD) symptomsAttention-deficit/hyperactivity disorderLarge-scale brain networksADHD polygenic risk scoresHyperactivity disorder symptomsSegregation of networksFunctional network segregationLongitudinal community-based cohortAttentional processesRs-fMRI dataExecutive functionHyperactivity disorderDisorder symptomsBrain networksCommunity-based sampleProbable ADHDADHDNetwork segregationPolygenic risk scoresDirection of association
2022
Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways
Axelrud L, Hoffmann M, Vosberg D, Santoro M, Pan P, Gadelha A, Belangero S, Miguel E, Shin J, Thapar A, Smoller J, Pausova Z, Rohde L, Keller M, Paus T, Salum G. Disentangling the influences of parental genetics on offspring's cognition, education, and psychopathology via genetic and phenotypic pathways. Journal Of Child Psychology And Psychiatry 2022, 64: 408-416. PMID: 36162806, DOI: 10.1111/jcpp.13708.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderPolygenic scoresOffspring cognitionIntergenerational transmissionMultiple mediation modelEducational attainmentBehavioral traitsCognitive measuresExecutive functionGeneral intelligenceHyperactivity disorderMediation modelMultiple mediationCognitive AssessmentCognitionPsychopathologyGenetic influencesParental educationPsychotic symptomsDirect associationParental geneticsAttainmentDiscovery sampleGenetic riskFathersThe Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome
Ferrão Y, de Alvarenga P, Hounie A, de Mathis M, Farhat L, do Rosário M, Miguel E. The Phenomenology of Obsessive–Compulsive Symptoms in Tourette Syndrome. 2022, 45-64. DOI: 10.1093/med/9780197543214.003.0004.Peer-Reviewed Original ResearchTourette syndromeObsessive-compulsive disorderObsessive-compulsive symptomsComorbid obsessive-compulsive disorderPost-traumatic stress disorderAttention-deficit/hyperactivity disorderPsychiatric comorbidityBasal gangliaBehavioral comorbiditiesSeparation anxiety disorderTreatment approachesClinical practiceComorbid diagnosesSymptom presentationComorbiditiesSimple phobiaStress disorderAnxiety disordersHyperactivity disorderSymptomsDisordersGenetic vulnerabilityBehavioral problemsSyndromeInattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life
de Oliveira J, Fatori D, Shephard E, Xavier M, Matijasevich A, Ferraro A, Rohde L, Chiesa A, Miguel E, Polanczyk G. Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. Brazilian Journal Of Psychiatry 2022, 44: 388-400. PMID: 35751597, PMCID: PMC9375657, DOI: 10.47626/1516-4446-2021-2045.Peer-Reviewed Original ResearchConceptsMaternal attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderHyperactivity/impulsivity symptomsInattention symptomsImpulsivity symptomsAdolescent mothersHyperactivity disorderMaternal inattentionInfant maltreatmentEarly intervention programsParenting skillsPoor home environmentInfant developmentIntervention programsInattentionChild maltreatmentMaternal competenceMaltreatmentSkillsHome visit programHome environmentFirst yearInfant's lifeMultilevel linear regression modelsEarly pregnancy
2021
Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action
Terra T, Schafer J, Pan P, Costa A, Caye A, Gadelha A, Miguel E, Bressan R, Rohde L, Salum G. Mental health conditions in Lesbian, Gay, Bisexual, Transgender, Queer and Asexual youth in Brazil: A call for action. Journal Of Affective Disorders 2021, 298: 190-193. PMID: 34715179, DOI: 10.1016/j.jad.2021.10.108.Peer-Reviewed Original ResearchConceptsAsexual youthMental disordersWell-Being Behavior AssessmentHigh-risk cohortMental health conditionsPost-traumatic stress disorderAttention deficit hyperactivity disorderMental health problemsDeficit hyperactivity disorderMental health disparitiesStressful life eventsDepressive disorderPsychiatric disordersPrevalence estimatesHealth problemsConfidential questionnaireHealth disparitiesLogistic regressionStress disorderAnxiety disordersHealth conditionsConduct disorderGroup comparisonsHyperactivity disorderDisordersDisability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits.
Zaqueu L, Teixeira M, Lowenthal R, Mari J, Miguel E, Rohde L, Paula C. Disability in children and adolescents: the extent of the impact on psychiatric disorders and educational deficits. Trends In Psychiatry And Psychotherapy 2021, 43: 235-239. PMID: 34860479, PMCID: PMC8638709, DOI: 10.47626/2237-6089-2020-0059.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderChildren/adolescentsAcademic performanceTypical developmentSchool failureType of disabilityPsychiatric disordersDeficit hyperactivity disorderEducational deficitsPoor academic performanceWorse academic performanceBrazilian children/adolescentsPresence of disabilityMental health problemsSchool-aged childrenMiddle-income countriesHyperactivity disorderSixth gradersMulticenter cross-sectional studyAdolescentsTen Questions QuestionnaireCross-sectional studyIntellectual disabilityLogistic regression modelsSpecific interventions
2020
Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents
Manfro A, Pine D, Polanczyk G, Santoro M, Smoller J, Koenen K, Mari J, Pan P, Zugman A, Schäfer J, Belangero S, Gosmann N, Simioni A, Hoexter M, Miguel E, Gadelha A, Rohde L, Salum G. Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 60: 1501-1512. PMID: 33346031, PMCID: PMC10259767, DOI: 10.1016/j.jaac.2020.11.016.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresPsychiatric diagnosisExecutive functionHigher schizophrenia polygenic risk scoresExecutive dysfunctionHigh Risk Cohort StudySmaller intracranial volumeHigher attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderSchizophrenia polygenic risk scoresCortical surface areaDichotomized ageCohort studyFunctional impairmentRisk scoreDomains of psychopathologyBrain regionsIntracranial volumeRelevant outcomesBrain structuresHyperactivity disorderCognitive tasksLatent class analysisLower chanceDiagnosis
2019
Relative Age and Attention-Deficit/Hyperactivity Disorder: Data From Three Epidemiological Cohorts and a Meta-analysis
Caye A, Petresco S, de Barros A, Bressan R, Gadelha A, Gonçalves H, Manfro A, Matijasevich A, Menezes A, Miguel E, Munhoz T, Pan P, Salum G, Santos I, Kieling C, Rohde L. Relative Age and Attention-Deficit/Hyperactivity Disorder: Data From Three Epidemiological Cohorts and a Meta-analysis. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 990-997. PMID: 31442562, DOI: 10.1016/j.jaac.2019.07.939.Peer-Reviewed Original ResearchConceptsYounger ageADHD diagnosisMeta-AnalysisADHD symptomsPelotas cohortCommunity-based cohortPopulation-based cohortAttention-deficit/hyperactivity disorderHigh-risk studiesRelative young ageAttention-deficit/hyperactivity disorder (ADHD) symptomsWeb of ScienceHyperactivity disorder symptomsEpidemiology guidelinesEligible recordsRelative riskObservational studyHigh riskPsychiatric disordersEpidemiological cohortCohortSymptomsDiagnosisEffect estimatesHyperactivity disorderEffects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil
Shephard E, Fatori D, Mauro L, de Medeiros Filho M, Hoexter M, Chiesa A, Fracolli L, Brentani H, Ferraro A, Nelson C, Miguel E, Polanczyk G. Effects of Maternal Psychopathology and Education Level on Neurocognitive Development in Infants of Adolescent Mothers Living in Poverty in Brazil. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 925-934. PMID: 31345780, PMCID: PMC6863387, DOI: 10.1016/j.bpsc.2019.05.009.Peer-Reviewed Original ResearchConceptsLow maternal educationMaternal psychopathologyAttention-deficit/hyperactivity disorderMaternal anxietyNeurocognitive developmentInfant neurodevelopmentAdolescent mothersMaternal educationHyperactivity disorderInfant neurocognitive developmentMonths of ageResting-state electroencephalographyCluster-based permutation testingEducation levelOscillatory powerEarly brain developmentMaternal symptomsRisk factorsConnectivity alterationsEarly neurocognitive developmentOscillatory connectivityRelative theta powerFunctional connectivityBrain developmentPilot studyThe impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects
Blanco‐Vieira T, Santos M, Ferrão YA, Torres AR, Miguel EC, Bloch MH, Leckman JF, do Rosario MC. The impact of attention deficit hyperactivity disorder in obsessive‐compulsive disorder subjects. Depression And Anxiety 2019, 36: 533-542. PMID: 30990937, DOI: 10.1002/da.22898.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderAdult OCD patientsObsessive-compulsive disorderDeficit hyperactivity disorderOCD patientsClinical characteristicsExact testFeatures of ADHDHyperactivity disorderSubgroup of patientsAdult obsessive-compulsive disorderComorbid attention deficit hyperactivity disorderSpecific clinical featuresCross-sectional studyObsessive-compulsive disorder (OCD) subjectsLogistic regression analysisFisher's exact testBrazilian Research ConsortiumMann-Whitney testAdult patientsRheumatic feverDevelopment of interventionsClinical featuresObsessive-compulsive spectrum disordersLifetime prevalence
2018
Diagnostic operationalization and phenomenological heterogeneity in psychiatry: the case of attention deficit hyperactivity disorder
Salum G, Gadelha A, Polanczyk G, Miguel E, Rohde L. Diagnostic operationalization and phenomenological heterogeneity in psychiatry: the case of attention deficit hyperactivity disorder. Salud Mental 2018, 41: 249-259. DOI: 10.17711/sm.0185-3325.2018.037.Peer-Reviewed Original ResearchAttention deficit hyperactivity disorderDeficit hyperactivity disorderHyperactivity disorderPhenomenological heterogeneityADHD symptomsTest-rest reliabilitySymptomatic thresholdSymptomatic scalesPathophysiological heterogeneityPsychiatric disordersPsychiatric diagnosisMental disordersSymptomsDiagnostic operationalizationsADHD diagnosisDisordersCross-Sectional and Longitudinal Associations of Temperament and Mental Disorders in Youth
Hoffmann M, Pan P, Manfro G, de Jesus Mari J, Miguel E, Bressan R, Rohde L, Salum G. Cross-Sectional and Longitudinal Associations of Temperament and Mental Disorders in Youth. Child Psychiatry & Human Development 2018, 50: 374-383. PMID: 30259212, DOI: 10.1007/s10578-018-0846-0.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDisruptive behavior disordersEffortful controlLongitudinal associationsMental disordersWell-Being Behavior AssessmentEffects of temperamentConfirmatory factor analysisTemperament factorsHyperactivity disorderBifactor modelTemperament QuestionnaireAdjusted longitudinal analysesTemperamentBehavior disorderDistressFactor analysisParental interviewsPhobiaBehavior assessmentLongitudinal analysisYouthDisordersLogistic regression modelsEATQ
2017
Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample
Pan P, Sato J, Salum G, Rohde L, Gadelha A, Zugman A, Mari J, Jackowski A, Picon F, Miguel E, Pine D, Leibenluft E, Bressan R, Stringaris A. Ventral Striatum Functional Connectivity as a Predictor of Adolescent Depressive Disorder in a Longitudinal Community-Based Sample. American Journal Of Psychiatry 2017, 174: 1112-1119. PMID: 28946760, PMCID: PMC10752293, DOI: 10.1176/appi.ajp.2017.17040430.Peer-Reviewed Original ResearchConceptsResting-state functional MRIIntrinsic functional connectivityDepressive disorderFunctional connectivityFunctional MRIReward networkFuture depressive disorderAdolescent depressive disordersLeft ventral striatumOnset of depressionBrain reward networksAberrant reward processingAttention deficit hyperactivity disorderDeficit hyperactivity disorderLongitudinal communityChildren 6Ventral striatumAdolescent depressionLogistic regressionHyperactivity disorderSubstance useYouth depressionDisordersDepressionFuture risk
2016
Erratum: Corrigendum: An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder
Lima L, Feio-dos-Santos A, Belangero S, Gadelha A, Bressan R, Salum G, Pan P, Moriyama T, Graeff-Martins A, Tamanaha A, Alvarenga P, Krieger F, Fleitlich-Bilyk B, Jackowski A, Brietzke E, Sato J, Polanczyk G, Mari J, Manfro G, do Rosário M, Miguel E, Puga R, Tahira A, Souza V, Chile T, Gouveia G, Simões S, Chang X, Pellegrino R, Tian L, Glessner J, Hashimoto R, Rohde L, Sleiman P, Hakonarson H, Brentani H. Erratum: Corrigendum: An integrative approach to investigate the respective roles of single-nucleotide variants and copy-number variants in Attention-Deficit/Hyperactivity Disorder. Scientific Reports 2016, 6: 25861. PMID: 27216920, PMCID: PMC4877574, DOI: 10.1038/srep25861.Peer-Reviewed Original ResearchMeasuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis
Salum G, DeSousa D, Manfro G, Pan P, Gadelha A, Brietzke E, Miguel E, Mari J, do Rosário M, Grassi-Oliveira R. Measuring child maltreatment using multi-informant survey data: a higher-order confirmatory factor analysis. Trends In Psychiatry And Psychotherapy 2016, 38: 23-32. PMID: 27007940, DOI: 10.1590/2237-6089-2015-0036.Peer-Reviewed Original ResearchConceptsConfirmatory factor analysisChild maltreatmentOppositional defiant disorder/conduct disorderAttention deficit hyperactivity disorderHigher-order confirmatory factor analysisMulti-informant approachDeficit hyperactivity disorderLower-order factorsLarge community sampleMulti-informant survey dataHigher-order factorsFactor analysisMeasures of psychopathologyTeacher-reported scoresOverall child maltreatmentFear disordersProsocial measuresHyperactivity disorderBrief measureDistress disordersCommunity sampleConduct disorderEmotional abuseDivergent validitySexual abuse
2014
An Inherited Small Microdeletion at 15q13.3 in a Patient with Early- Onset Obsessive-Compulsive Disorder
Cappi C, Hounie A, Mariani D, Diniz J, Silva A, Reis V, Busso A, Silva A, Fidalgo F, Rogatto S, Miguel E, Krepischi A, Brentani H. An Inherited Small Microdeletion at 15q13.3 in a Patient with Early- Onset Obsessive-Compulsive Disorder. PLOS ONE 2014, 9: e110198. PMID: 25303678, PMCID: PMC4193873, DOI: 10.1371/journal.pone.0110198.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge of OnsetCase-Control StudiesChildChild, PreschoolChromosome DeletionChromosomes, Human, Pair 15Comparative Genomic HybridizationDNA Copy Number VariationsFetal ProteinsForminsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMicrofilament ProteinsNuclear ProteinsObsessive-Compulsive DisorderConceptsObsessive-compulsive disorderOnset obsessive-compulsive disorderEarly-onset obsessive-compulsive disorderAttention deficit hyperactivity disorderArray-based comparative genomic hybridizationNeurodevelopmental psychiatric disordersDeficit hyperactivity disorderGlutamatergic involvementMale patientsGlutamatergic systemPsychiatric disordersHealthy individualsPatientsHyperactivity disorderGenetic riskComparative genomic hybridizationDisordersSmall microdeletionsChromosome 15q13.3Present studyGenomic hybridizationMicrodeletionCohort
2013
The Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome
FerrãO Y, De Alvarenga P, Hounie A, De Mathis M, De RosáRio M, Miguel E. The Phenomenology of Obsessive-Compulsive Symptoms in Tourette Syndrome. 2013, 50-73. DOI: 10.1093/med/9780199796267.003.0003.Peer-Reviewed Original ResearchObsessive-compulsive disorderTourette syndromeObsessive-compulsive symptomsComorbid obsessive-compulsive disorderAttention-deficit/hyperactivity disorderPosttraumatic stress disorderPsychiatric comorbidityBehavioral comorbiditiesSeparation anxiety disorderClinical practiceComorbid diagnosesComorbiditiesSymptomsSimple phobiaStress disorderAnxiety disordersHyperactivity disorderDisordersSyndromeBehavioral problems
2008
Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns
de Mathis M, do Rosario M, Diniz J, Torres A, Shavitt R, Ferrão Y, Fossaluza V, de Bragança Pereira C, Miguel E. Obsessive–compulsive disorder: Influence of age at onset on comorbidity patterns. European Psychiatry 2008, 23: 187-194. PMID: 18329252, DOI: 10.1016/j.eurpsy.2008.01.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge of OnsetAnxiety DisordersAttention Deficit Disorder with HyperactivityBrazilComorbidityCross-Sectional StudiesDisruptive, Impulse Control, and Conduct DisordersFeeding and Eating DisordersFemaleHumansMaleMental DisordersMiddle AgedObsessive-Compulsive DisorderPersonality AssessmentSex FactorsSomatoform DisordersTic DisordersConceptsImpulse control disordersInfluence of ageComorbidity patternsYale Global Tic Severity ScaleOCD patientsStructured Clinical InterviewTic Severity ScaleYale-Brown Obsessive Compulsive ScaleAttention-deficit/hyperactivity disorderObsessive Compulsive ScalePsychiatric comorbidityIllness durationTic disordersFemale genderSeverity ScaleClinical InterviewDSM-IVLower ageAnxiety disordersCompulsive ScaleHyperactivity disorderDisordersLower chanceAgeComorbidities
2004
Transtorno de déficit de atenção/hiperatividade na infância e na adolescência: considerações clínicas e terapêuticas
Rohde L, Filho E, Benetti L, Gallois C, Kieling C. Transtorno de déficit de atenção/hiperatividade na infância e na adolescência: considerações clínicas e terapêuticas. Archives Of Clinical Psychiatry 2004, 31: 124-131. DOI: 10.1590/s0101-60832004000300002.Peer-Reviewed Original ResearchBipolar disorderAttention-deficit/hyperactivity disorderNon-systematic reviewPharmacological managementTherapeutic dilemmaDifferential diagnosisPrevalent disorderComorbid disordersClinical relevancePrecise diagnosisClinical tipsHyperactivity disorderDisordersClinical psychiatristsImpairment criteriaDiagnosisImportant impairmentComorbiditiesTreatmentAdequate useMedicationsReviewImpairment