2024
Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling
Ohashi Y, Protack C, Aoyagi Y, Gonzalez L, Thaxton C, Zhang W, Kano M, Bai H, Yatsula B, Alves R, Hoshina K, Schneider E, Long X, Perry R, Dardik A. Heterogeneous gene expression during early arteriovenous fistula remodeling suggests that downregulation of metabolism predicts adaptive venous remodeling. Scientific Reports 2024, 14: 13287. PMID: 38858395, PMCID: PMC11164895, DOI: 10.1038/s41598-024-64075-8.Peer-Reviewed Original ResearchConceptsGene expression patternsArteriovenous fistula groupArteriovenous fistulaExpression patternsHeterogeneous gene expressionGene expression changesOutcomes of arteriovenous fistulaVenous remodelingArteriovenous fistula maturationPostoperative day 7Reduce patient morbidityRNA sequencingUpregulation of metabolismBioinformatics analysisGene expressionDownregulation of metabolismMetabolic pathwaysExpression changesGenesAVF maturationAVF remodelingFistula creationC57BL/6 miceClinical outcomesPatient morbidityCommon Data Elements and Databases Essential for the Study of Musculoskeletal Injuries in Military Personnel
Juman L, Schneider E, Clifton D, Koehlmoos T. Common Data Elements and Databases Essential for the Study of Musculoskeletal Injuries in Military Personnel. Military Medicine 2024, 189: e2146-e2152. PMID: 38771112, DOI: 10.1093/milmed/usae241.Peer-Reviewed Original ResearchMilitary Health SystemMusculoskeletal injuriesService membersData elementsMedical encountersMilitary Health System Data RepositoryInjury statisticsPrevent musculoskeletal injuriesMilitary personnelBranch of serviceInjury preventionHealth systemCommon Data ElementsCore data elementsCommon Procedural Terminology codesForce readinessMedical assessmentEnvironmental scanSnowball samplingProcedural Terminology codesEvidence-informed policy decisionsMedical conditionsDisease burdenDeployment statusActive engagement
2023
Emergent Applications of Machine Learning for Diagnosing and Managing Appendicitis: A State-of-the-Art Review
Bhandarkar S, Tsutsumi A, Schneider E, Ong C, Paredes L, Brackett A, Ahuja V. Emergent Applications of Machine Learning for Diagnosing and Managing Appendicitis: A State-of-the-Art Review. Surgical Infections 2023, 25: 7-18. PMID: 38150507, DOI: 10.1089/sur.2023.201.Peer-Reviewed Original ResearchArtificial intelligence toolsNew artificial intelligence toolsArtificial neural networkSupport vector machineMachine learning-based toolLearning-based toolIntelligence toolsMachine learningUse casesNeural networkVector machineRandom forestAverage accuracyNovel solutionMachineEmergent applicationsAlgorithmOptimal modelQueriesHigh operator dependencyArt reviewAccuracyToolNetworkOperator dependencyDiverticulitis in Older Adults: Is Cognitive Impairment Associated With Outcomes?
Kodadek L, Moore M, Canner J, Schneider E. Diverticulitis in Older Adults: Is Cognitive Impairment Associated With Outcomes? Journal Of Surgical Research 2023, 291: 359-366. PMID: 37506436, DOI: 10.1016/j.jss.2023.06.015.Peer-Reviewed Original ResearchConceptsColonic diverticulitisCognitive impairmentEmergency departmentOlder adultsHospital mortalityOperative interventionInpatient admissionsPrimary diagnosisMultivariable Poisson regression modelsNationwide Emergency Department SamplePrimary payer statusRetrospective cohort studyElixhauser Comorbidity IndexEmergency Department SampleComorbid cognitive impairmentPoisson regression modelsComorbidity indexComplicated diverticulitisCognitive impairment statusCohort studyED encountersPatient ageED carePayer statusRelative riskAn Evaluation of Sex-Based Differences in Surrogate Consent for Older Adults Undergoing Surgical Intervention
Nagarkatti N, Miller S, Ahuja V, Schneider E, Mohanty S, Kodadek L. An Evaluation of Sex-Based Differences in Surrogate Consent for Older Adults Undergoing Surgical Intervention. Journal Of Surgical Research 2023, 288: 246-251. PMID: 37030182, DOI: 10.1016/j.jss.2023.02.041.Peer-Reviewed Original ResearchConceptsPreoperative cognitive impairmentMale patientsCognitive impairmentSurrogate consentSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramPatients age 65Preoperative cognitive statusQuality Improvement ProgramHigh rateSex-based differencesFemale patientsPatient sexSurgical interventionStratified analysisFacets of medicineAge 75American CollegePatientsAge 65Cognitive statusDescriptive studyOlder adultsAge categoriesArterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation
Satam K, Setia O, Moore M, Schneider E, Chaar C, Dardik A. Arterial Diameter and Percentage of Monocytes are Sex-Dependent Predictors of Early Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2023, 93: 128-136. PMID: 36812979, PMCID: PMC10277224, DOI: 10.1016/j.avsg.2023.01.052.Peer-Reviewed Original ResearchConceptsFistula maturationArteriovenous fistula maturationArterial diameterArteriovenous fistulaFistula creationBrachial artery diameterPrimary arteriovenous fistulaPercentage of neutrophilsPeak systolic velocityPercentage of monocytesBrachial-cephalic fistulaElectronic medical recordsSex differencesFistula utilizationInferior patencyPostoperative ultrasoundUnassisted maturationYears postprocedureSingle centerArtery diameterArterial inflowArterial velocitySystolic velocityMedical recordsMonocyte percentagePalliative Care in a Pandemic: A Multicenter Cohort of Critically Ill Patients with Coronavirus Disease 2019
Kodadek L, Moore M, Miller S, Schneider E, Ahuja V, Maerz L, Davis K. Palliative Care in a Pandemic: A Multicenter Cohort of Critically Ill Patients with Coronavirus Disease 2019. Surgical Infections 2023, 24: 190-198. PMID: 36757283, PMCID: PMC10081705, DOI: 10.1089/sur.2022.377.Peer-Reviewed Original ResearchConceptsIntensive care unitPalliative careIll patientsCoronavirus disease 2019Life careClinical characteristicsMechanical ventilationDisease 2019Acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCoronavirus 2 infectionPalliative care consultationPalliative care servicesCOVID-19Outcomes of interestHospital lengthAdult patientsComorbid diseasesDisease courseMulticenter cohortCare unitCare consultationsVaccination dataPatients
2022
Indoor Versus Outdoor: Does Occupational Sunlight Exposure Increase Melanoma Risk? A Systematic Review
Maduka R, Tai K, Gonsai R, DeWalt N, Chetty A, Brackett A, Olino K, Schneider E, Ahuja V. Indoor Versus Outdoor: Does Occupational Sunlight Exposure Increase Melanoma Risk? A Systematic Review. Journal Of Surgical Research 2022, 283: 274-281. PMID: 36423476, DOI: 10.1016/j.jss.2022.10.025.Peer-Reviewed Original ResearchConceptsCutaneous melanomaSystematic reviewOutdoor occupationsGrading of RecommendationsChronic occupational exposureRetrospective case controlInternational Prospective RegisterNew cancer casesMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsInitial database searchFull-text screeningCutaneous melanoma developmentEvidence certaintyCohort studyScreening recommendationsCommon cancerRisk factorsStudy protocolProspective RegisterCase ascertainmentCancer casesOccupational exposureStudy qualityCase controlBlood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study
Agoston D, McCullough J, Aniceto R, Lin I, Kamnaksh A, Eklund M, Graves W, Dunbar C, Engall J, Schneider E, Leonessa F, Duckworth J. Blood-Based Biomarkers of Repetitive, Subconcussive Blast Overpressure Exposure in the Training Environment: A Pilot Study. Neurotrauma Reports 2022, 3: 479-490. PMID: 36337080, PMCID: PMC9634979, DOI: 10.1089/neur.2022.0029.Peer-Reviewed Original ResearchTraumatic brain injuryMatrix metalloprotease-9Serum levelsClaudin-5Ubiquitin C-terminal hydrolase L1Pilot studyUnknown long-term effectsElevated autoantibody titersGlial fibrillary acidic proteinMild traumatic brain injuryElevated serum levelsBlood-based biomarkersAlpha 7 subunitChronic degenerative processMolecular changesFibrillary acidic proteinBlast overpressure exposureAutoantibody titersAutoimmune processVascular changesElevated titersBrain injuryLong-term effectsBlood samplesMetalloprotease-9Surrogate consent for surgery among older adult patients
Miller SM, Nagarkatti N, Ahuja V, Schneider EB, Mohanty S, Rosenthal RA, Kodadek LM. Surrogate consent for surgery among older adult patients. Surgery 2022, 172: 1748-1752. PMID: 36123180, DOI: 10.1016/j.surg.2022.08.015.Peer-Reviewed Original ResearchConceptsHalf of patientsCognitive impairmentSurrogate consentHigher comorbidity burdenOlder adult patientsComorbidity burdenPreoperative disabilityAdult patientsOlder patientsFemale patientsSurgical interventionElective proceduresSurgical proceduresHealth characteristicsAmerican CollegeDaily livingOwn consentPatientsOlder adultsImpairmentSurgeryConsentDescriptive analysisFurther researchDiagnosisThe collaborative research and service delivery partnership between the United States healthcare system and the U.S. Military Health System during the COVID-19 pandemic
Koehlmoos T, Korona-Bailey J, Janvrin M, Madsen C, Schneider E. The collaborative research and service delivery partnership between the United States healthcare system and the U.S. Military Health System during the COVID-19 pandemic. Health Research Policy And Systems 2022, 20: 81. PMID: 35854348, PMCID: PMC9295105, DOI: 10.1186/s12961-022-00885-4.Peer-Reviewed Original ResearchConceptsMilitary Health SystemHealth systemHealthcare systemU.S. Military Health SystemWorld Health Organization frameworkUnited States healthcare systemU.S. healthcare systemProvision of suppliesStates healthcare systemCOVID-19 pandemicCollaborative effortsHealthcare deliveryProvider supportTreatment venueGrey literatureHealth challengesAreas of medicineHealthHealth emergencyDevelopment of vaccinesCOVID-19ProvidersNation's abilityHuman resourcesCollaborative research837 Shunt-dependent Post Traumatic Hydrocephalus in Pediatric Patients with Moderate to Severe Traumatic Brain Injury (TBI)
Asemota A, Schneider E. 837 Shunt-dependent Post Traumatic Hydrocephalus in Pediatric Patients with Moderate to Severe Traumatic Brain Injury (TBI). Neurosurgery 2022, 68: 143-144. DOI: 10.1227/neu.0000000000001880_837.Peer-Reviewed Original ResearchPost-traumatic hydrocephalusTraumatic brain injuryVP shunt placementPediatric patientsBrain injuryHigher oddsMedian age 4 yearsNationwide Inpatient Sample 2000ICD-9-CM codesSevere traumatic brain injuryHigh inpatient morbidityPediatric TBI casesPediatric TBI patientsAcute respiratory failureMean patient ageAcute renal failureCongestive cardiac failureVentilator-Associated PneumoniaDeep vein thrombosisModerate-severe traumatic brain injuryMotor vehicle accidentsAge 4 yearsAge group categoriesMajority of casesTraumatic hydrocephalus
2021
Non-Operative Shoulder Dysfunction in the United States Military
Leggit J, Wu H, Janvrin M, Korona-Bailey J, Koehlmoos T, Schneider E. Non-Operative Shoulder Dysfunction in the United States Military. Military Medicine 2021, 188: e1003-e1009. PMID: 34865115, DOI: 10.1093/milmed/usab468.Peer-Reviewed Original ResearchConceptsMilitary Health SystemUpper arm injuriesShoulder dysfunctionForce readinessMilitary Health System Data RepositoryTreatment of shoulder dysfunctionService membersPhysical fitness domainActive duty military service membersDiagnosis of shoulderHealth services researchActive duty service membersType of careFiscal yearDuty service membersActive duty membersMilitary service membersTotal Force FitnessLaboratory test costsHealth servicesHealth systemRetrospective cohort studyFunctional limitationsNonoperative conditionsNonoperative careMethylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer
Ying L, Sharma A, Chhoda A, Ruzgar N, Hasan N, Kwak R, Wolfgang CL, Wang TH, Kunstman JW, Salem RR, Wood LD, Iacobuzio-Donahue C, Schneider EB, Farrell JJ, Ahuja N. Methylation-based Cell-free DNA Signature for Early Detection of Pancreatic Cancer. Pancreas 2021, 50: 1267-1273. PMID: 34860810, DOI: 10.1097/mpa.0000000000001919.Peer-Reviewed Original Research
2020
Can an Academic RVU Model Balance the Clinical and Research Challenges in Surgery?
Dunn A, Walsh R, Lipman J, French J, Jeyarajah D, Schneider E, Delaney C, Augustin T. Can an Academic RVU Model Balance the Clinical and Research Challenges in Surgery? Journal Of Surgical Education 2020, 77: 1473-1480. PMID: 32768381, DOI: 10.1016/j.jsurg.2020.05.029.Peer-Reviewed Original ResearchConceptsNational CommitteeGeneral surgery programsAcademic surgical departmentsClinical activitySurgical departmentSurgeon characteristicsSurgery programProgram directorsClinical settingSurgeon demographicsClinical expectationsGrand roundsAcademic surgeonsSurgeryPractice environmentSurvey-based studyMost respondentsSurgeonsDemographicsRespondent characteristicsClinical productivityAcademic productivityClinicalSetting
2019
Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort
Hawkins R, Mehaffey J, Charles E, Kern J, Schneider E, Tracci M. Socioeconomically Distressed Communities Index independently predicts major adverse limb events after infrainguinal bypass in a national cohort. Journal Of Vascular Surgery 2019, 70: 1985-1993.e8. PMID: 31761106, DOI: 10.1016/j.jvs.2019.03.060.Peer-Reviewed Original ResearchConceptsDistressed Communities IndexMajor adverse limb eventsAdverse limb eventsInfrainguinal bypassGraft occlusionIndependent predictorsLimb eventsMajor adverse cardiovascular eventsLong-term maleAdverse cardiovascular eventsOperative risk factorsCritical limb ischemiaMore comorbid diseasesCare-related outcomesHealth care-related outcomesPrior amputationHospital mortalityCardiovascular eventsComorbid diseasesLimb ischemiaSurgical outcomesNational cohortVascular diseaseRisk factorsUnivariate analysisTrends in Management of Cerebrospinal Fluid Leaks Among Pediatric Head Trauma Patients With Skull Base Fractures
Asemota A, Schneider E, Gallia G. Trends in Management of Cerebrospinal Fluid Leaks Among Pediatric Head Trauma Patients With Skull Base Fractures. Neurosurgery 2019, 66: 310-813. DOI: 10.1093/neuros/nyz310_813.Peer-Reviewed Original ResearchEffect of Travel Time for Thyroid Surgery on Treatment Cost and Morbidity
Ramirez A, Schneider E, Mehaffey J, Zeiger M, Hanks J, Smith P. Effect of Travel Time for Thyroid Surgery on Treatment Cost and Morbidity. The American Surgeon 2019, 85: 949-955. PMID: 31638505, DOI: 10.1177/000313481908500934.Peer-Reviewed Original ResearchConceptsHigh-volume centersThyroid surgeryPrimary outcomeHospital costsSingle high-volume centerMedian operative timeHealth care utilizationCertain patient populationsMultivariable regression modelingPatient's home addressHome addressPostoperative morbidityACS-NSQIPOperative timePatient populationUninsured statusThyroid diseaseEndocrine surgeryMorbidity riskThyroid proceduresSurgical careTime-related differencesPatient differencesDisease processPatientsVariation in the use of MRI for cervical spine clearance: an opportunity to simultaneously improve clinical care and decrease cost
Albaghdadi A, Leeds IL, Florecki KL, Canner JK, Schneider EB, Sakran JV, Haut ER. Variation in the use of MRI for cervical spine clearance: an opportunity to simultaneously improve clinical care and decrease cost. Trauma Surgery & Acute Care Open 2019, 4: e000336. PMID: 31392284, PMCID: PMC6660802, DOI: 10.1136/tsaco-2019-000336.Peer-Reviewed Original ResearchBlunt trauma patientsUse of MRICervical spine clearanceInjury Severity ScoreTrauma centerTrauma patientsMRI useSpine clearanceNational guidelinesLevel 1 trauma centerNational Trauma Data BankHospital-level factorsProportion of patientsGlasgow Coma ScalePatient-level characteristicsTrauma center levelBest practice careCervical spine evaluationCurrent national guidelinesTrauma Data BankRecent national guidelinesHospital-specific factorsMotor vehicle collisionsAbbreviated Injury ScaleNon-teaching hospitalsCollecting sexual orientation and gender identity information in the emergency department : the divide between patient and provider perspectives
Kodadek LM, Peterson S, Shields RY, German D, Ranjit A, Snyder C, Schneider E, Lau BD, Haider AH. Collecting sexual orientation and gender identity information in the emergency department : the divide between patient and provider perspectives. Emergency Medicine Journal 2019, 36: 136. PMID: 30630837, DOI: 10.1136/emermed-2018-207669.Peer-Reviewed Original ResearchConceptsED cliniciansED providersClinical circumstancesGender identity informationMost clinical circumstancesInstitute of MedicinePatients' sexual orientationGender minority patientsED encountersEmergency departmentMinority patientsPatients' viewsPatientsAcademic centersSimilar careProvider perspectivesJoint CommissionPrior reportsDiscordant perspectivesRoutine collectionConstant comparative methodCliniciansPurposive sampleTherapeutic relationshipCare