2020
Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia
Paidas MJ, Tita ATN, Macones GA, Saade GA, Ehrenkranz RA, Triche EW, Streisand JB, Lam GK, Magann EF, Lewis DF, Dombrowski MP, Werner EF, Branch DW, Habli MA, Grotegut CA, Silver RM, Longo SA, Amon E, Cleary K, How HY, Novotny SR, Grobman WA, Whiteman VE, Wing DA, Scifres CM, Sibai BM. Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia. American Journal Of Obstetrics And Gynecology 2020, 223: 739.e1-739.e13. PMID: 32780999, DOI: 10.1016/j.ajog.2020.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdolescentAdultAntithrombin ProteinsCesarean SectionDelivery, ObstetricDouble-Blind MethodFemaleFetal DistressGestational AgeHumansInfant, Premature, DiseasesInfant, Small for Gestational AgeMiddle AgedNeonatal SepsisPerinatal MortalityPre-EclampsiaPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdProspective StudiesRecombinant ProteinsYoung AdultConceptsRecombinant human antithrombinPreterm preeclampsiaExpectant managementMorbidity scoreHuman antithrombinPlacebo-controlled clinical trialPlacebo-controlled evaluationPlacebo-controlled trialMedian gestational ageMaternal complicationsVersus PlaceboFetal outcomesMaternal outcomesPreterm deliveryEndothelial dysfunctionSecondary outcomesSingleton pregnanciesStandard therapyLoading dosePrimary outcomeWeeks' gestationGestational ageContinuous infusionClinical trialsSaline infusion
2015
The Rising Burden of Preeclampsia in the United States Impacts Both Maternal and Child Health
Shih T, Peneva D, Xu X, Sutton A, Triche E, Ehrenkranz RA, Paidas M, Stevens W. The Rising Burden of Preeclampsia in the United States Impacts Both Maternal and Child Health. American Journal Of Perinatology 2015, 33: 329-338. PMID: 26479171, DOI: 10.1055/s-0035-1564881.Peer-Reviewed Original ResearchConceptsEarly-onset preeclampsiaNumerous adverse health consequencesHealth consequencesConsiderable perinatal morbidityAdverse health consequencesEstimates of burdenSeverity of outcomePerinatal morbidityPreterm deliveryPreterm birthTerm pregnancyMaternal mortalityUS incidencePreeclampsiaChild healthEffective treatmentEconomic burdenRising BurdenSocial burdenHealth careBurdenMortalityUnited StatesHealthMothersFolic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery
Martinussen MP, Bracken MB, Triche EW, Jacobsen GW, Risnes KR. Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2015, 195: 94-99. PMID: 26500184, PMCID: PMC4684439, DOI: 10.1016/j.ejogrb.2015.09.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFolic AcidHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeObesityOdds RatioPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy Trimester, FirstPremature BirthProspective StudiesProtective FactorsRisk FactorsVitamin B ComplexYoung AdultConceptsFolic acid supplementationLow birth weightFolic acid intakePreterm birthAcid supplementationFirst trimesterLean mothersBirth weightAcid intakeEarly pregnancyOdds ratioGestational age offspringProspective cohort studyFolic acid supplementsFolic acid usePregnancy outcome dataRisk of preeclampsiaPossible protective effectMonths of pregnancyObese mothersPreterm deliveryCohort studyObstetric recordsAge offspringFolate intakeThe effect of labour induction on the risk of caesarean delivery: using propensity scores to control confounding by indication
Danilack V, Dore D, Triche E, Muri J, Phipps M, Savitz D. The effect of labour induction on the risk of caesarean delivery: using propensity scores to control confounding by indication. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 123: 1521-1529. PMID: 26411752, DOI: 10.1111/1471-0528.13682.Peer-Reviewed Original ResearchConceptsWeeks of gestationCaesarean deliveryLabor inductionRisk ratioPropensity scoreElevated riskNational Perinatal Information CenterPrimary caesarean deliveryRisk of caesareanAdministrative hospital discharge dataHospital discharge dataMedical record informationCross-sectional analysisExpectant managementPreterm deliveryLiveborn deliveryPropensity score methodsGestationMember hospitalsPS adjustmentWeeksCovariate adjustmentSubsequent weeksTraditional covariatesRisk
2014
Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study
Lundsberg LS, Illuzzi JL, Belanger K, Triche EW, Bracken MB. Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study. Annals Of Epidemiology 2014, 25: 46-54.e3. PMID: 25453352, PMCID: PMC4255148, DOI: 10.1016/j.annepidem.2014.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingConfidence IntervalsConfounding Factors, EpidemiologicConnecticutFemaleFetal Growth RetardationGestational AgeHumansInfant, Low Birth WeightInfant, NewbornLogistic ModelsMassachusettsMaternal-Fetal ExchangeOdds RatioPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthProspective StudiesRisk FactorsConceptsIntrauterine growth restrictionLow birthweightPreterm deliveryBirth lengthBirth outcomesGrowth restrictionAlcohol exposureOdds ratioLower oddsModerate prenatal alcohol exposureModerate alcohol exposureThird-trimester drinkingProspective cohort studyMultivariable logistic regressionConfidence intervalsPrenatal alcohol consumptionPrenatal alcohol exposurePregnancy drinkingNeonatal outcomesPerinatal outcomesSingleton infantsCohort studyAlcohol drinkingReduced oddsHead circumference
2012
Correction of Systematic Bias in Ultrasound Dating in Studies of Small-for-Gestational-Age Birth: An Example From the Iowa Health in Pregnancy Study
Harland K, Saftlas A, Wallis A, Yankowitz J, Triche E, Zimmerman M. Correction of Systematic Bias in Ultrasound Dating in Studies of Small-for-Gestational-Age Birth: An Example From the Iowa Health in Pregnancy Study. American Journal Of Epidemiology 2012, 176: 443-455. PMID: 22886591, PMCID: PMC3499119, DOI: 10.1093/aje/kws120.Peer-Reviewed Original ResearchConceptsLast menstrual periodUltrasound gestational ageGestational ageSGA birthEarly ultrasoundPreterm deliveryPopulation-based case-control studyFirst trimester vaginal bleedingFirst trimester prenatal careGestational age fetusesGestational-age birthsCase-control studyStandard guidelinesMultivariable linear regressionDifferent study populationsVaginal bleedingGestational durationSGA fetusesSGA subjectsPrenatal careMaternal ageMenstrual periodPregnancy StudyStudy populationUnadjusted models
2010
Mortality of mothers from cardiovascular and non‐cardiovascular causes following pregnancy complications in first delivery
Lykke JA, Langhoff‐Roos J, Lockwood CJ, Triche EW, Paidas MJ. Mortality of mothers from cardiovascular and non‐cardiovascular causes following pregnancy complications in first delivery. Paediatric And Perinatal Epidemiology 2010, 24: 323-330. PMID: 20618721, DOI: 10.1111/j.1365-3016.2010.01120.x.Peer-Reviewed Original ResearchConceptsNon-cardiovascular causesGestational age offspringEarly maternal deathPreterm deliveryCardiovascular causesHypertensive disordersPregnancy complicationsMaternal deathsEarly deathRegistry-based retrospective cohort studyCox proportional hazards modelFirst singleton deliveryMortality of mothersRetrospective cohort studyProportional hazards modelDenmark 1978Placental abruptionCohort studySingleton deliveriesLarge cohortFirst deliveryMortality hazardHazards modelSubsequent deathStrong marker
2009
Preterm delivery and risk of subsequent cardiovascular morbidity and type‐II diabetes in the mother
Lykke J, Paidas M, Damm P, Triche E, Kuczynski E, Langhoff‐Roos J. Preterm delivery and risk of subsequent cardiovascular morbidity and type‐II diabetes in the mother. BJOG An International Journal Of Obstetrics & Gynaecology 2009, 117: 274-281. PMID: 20015308, DOI: 10.1111/j.1471-0528.2009.02448.x.Peer-Reviewed Original ResearchConceptsRisk of thromboembolismType II diabetesPreterm deliveryCardiovascular morbiditySingleton deliveriesRegistry-based retrospective cohort studyCox proportional hazards modelFirst singleton deliveryHypertensive pregnancy disordersMaternal cardiovascular morbiditySecond singleton deliverySpecific cardiovascular eventsSubsequent cardiovascular morbidityRetrospective cohort studyIschemic heart diseaseWeeks of gestationYear of deliveryProportional hazards modelFetal growth deviationsMaternal hypertensionAdjusted riskCardiovascular eventsPlacental abruptionPregnancy complicationsCohort studyHypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother
Lykke JA, Langhoff-Roos J, Sibai BM, Funai EF, Triche EW, Paidas MJ. Hypertensive Pregnancy Disorders and Subsequent Cardiovascular Morbidity and Type 2 Diabetes Mellitus in the Mother. Hypertension 2009, 53: 944-951. PMID: 19433776, DOI: 10.1161/hypertensionaha.109.130765.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesCase-Control StudiesCohort StudiesDenmarkDiabetes Mellitus, Type 2FemaleHumansHypertension, Pregnancy-InducedIncidencePre-EclampsiaPregnancyPregnancy OutcomePregnancy RatePregnancy, High-RiskPremature BirthProbabilityProportional Hazards ModelsRegistriesSeverity of Illness IndexYoung AdultConceptsType 2 diabetes mellitusSubsequent type 2 diabetes mellitusHypertensive pregnancy disordersSubsequent cardiovascular eventsDiabetes mellitusGestational hypertensionSevere preeclampsiaPregnancy disordersSubsequent hypertensionCardiovascular eventsRegistry-based cohort studyConsecutive singleton deliveriesSubsequent cardiovascular morbidityCongestive heart failureIschemic heart diseaseCardiovascular morbidityPlacental abruptionPreterm deliveryThromboembolic eventsCohort studyMild preeclampsiaSingleton deliveriesHeart failureSubsequent thromboembolismGestational age
2006
Caffeine Metabolites in Umbilical Cord Blood, Cytochrome P-450 1A2 Activity, and Intrauterine Growth Restriction
Grosso LM, Triche EW, Belanger K, Benowitz NL, Holford TR, Bracken MB. Caffeine Metabolites in Umbilical Cord Blood, Cytochrome P-450 1A2 Activity, and Intrauterine Growth Restriction. American Journal Of Epidemiology 2006, 163: 1035-1041. PMID: 16641310, DOI: 10.1093/aje/kwj125.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionRisk of IUGRUmbilical cord bloodGrowth restrictionCord bloodCaffeine consumptionRatio of paraxanthineCytochrome PSelf-reported caffeine consumptionPreterm deliveryFetal exposureHighest quartileAdjusted analysisPregnant womenFetal growthObstetric practiceCYP1A2 activityParaxanthine levelsReproductive outcomesAdjusted modelAssociation of caffeineCaffeine metabolitesStandard deviation changeConflicting resultsQuartile
2005
Association of caffeine metabolites in umbilical cord blood with IUGR and preterm delivery: A prospective cohort study of 1609 pregnancies
Grosso L, Triche E, Belanger K, Benowitz N, Holford T, Bracken M. Association of caffeine metabolites in umbilical cord blood with IUGR and preterm delivery: A prospective cohort study of 1609 pregnancies. Annals Of Epidemiology 2005, 15: 659-660. DOI: 10.1016/j.annepidem.2005.07.037.Peer-Reviewed Original ResearchPreterm deliveryQuartile changeCohort studyCord bloodRatio of paraxanthineProspective cohort studyMethodsProspective cohort studyUmbilical cord bloodSelf-reported caffeine consumptionLogistic regression modelsOne-unit increaseThird trimesterSerum caffeineIUGRUmbilical cordCaffeine exposureReproductive outcomesAssociation of caffeineCaffeine consumptionHealth outcomesCaffeine ratioImportant covariatesRiskOutcomesBlood
2003
Asthma Symptoms, Severity, and Drug Therapy: A Prospective Study of Effects on 2205 Pregnancies
Bracken M, Triche E, Belanger K, Saftlas A, Beckett W, Leaderer B. Asthma Symptoms, Severity, and Drug Therapy: A Prospective Study of Effects on 2205 Pregnancies. Obstetrics And Gynecology 2003, 102: 739. DOI: 10.1097/00006250-200310000-00016.Peer-Reviewed Original ResearchAsthma symptomsOral steroidsAsthma diagnosisPreterm deliveryPregnant womenHistory of asthmaIntrauterine growth restrictionIUGR infantsAsthma guidelinesAsthma historyController medicationsModerate asthmaPregnant patientsAsthma therapySymptomatic patientsAsthma severityFetal effectsSymptomatic womenProspective studyDrug therapyGrowth restrictionΒ2 agonistsAsthmaSymptomsMedicationsAsthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies.
Bracken MB, Triche EW, Belanger K, Saftlas A, Beckett WS, Leaderer BP. Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies. Obstetrics And Gynecology 2003, 102: 739-52. PMID: 14551004, DOI: 10.1016/s0029-7844(03)00621-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Asthmatic AgentsAnti-Inflammatory AgentsAsthmaBirth WeightCase-Control StudiesConnecticutFemaleFetal Growth RetardationFetal Membranes, Premature RuptureHumansInfant, Low Birth WeightInfant, NewbornMassachusettsPregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesRisk FactorsSeverity of Illness IndexSteroidsTheophyllineConceptsAsthma symptomsOral steroidsAsthma diagnosisPreterm deliveryPregnant womenHistory of asthmaIntrauterine growth restrictionIUGR infantsAsthma guidelinesAsthma historyController medicationsModerate asthmaAsthma therapyPregnant patientsSymptomatic patientsAsthma severityFetal effectsSymptomatic womenProspective studyDrug therapyGrowth restrictionAsthmaSymptomsMedicationsDiagnosisAssociation of Maternal Caffeine Consumption with Decrements in Fetal Growth
Bracken MB, Triche EW, Belanger K, Hellenbrand K, Leaderer BP. Association of Maternal Caffeine Consumption with Decrements in Fetal Growth. American Journal Of Epidemiology 2003, 157: 456-466. PMID: 12615610, DOI: 10.1093/aje/kwf220.Peer-Reviewed Original ResearchConceptsMaternal caffeine consumptionIntrauterine growth retardationCaffeine consumptionBirth weightCreatinine increaseUrinary caffeineGrowth retardationFirst prenatal visitLarge prospective studiesLow birth weightMean birth weightImportant confounding factorsFetal hazardsPerinatal outcomesPreterm deliveryCreatinine levelsPregnancy outcomesPrenatal visitUrinary cotinineGestational ageSingleton livebirthsThird trimesterProspective studyFetal growthMedical records