2024
Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs
Wang T, Ling A, Billings S, Hosseini D, Vaisbuch Y, Kim G, Atkinson P, Sayyid Z, Aaron K, Wagh D, Pham N, Scheibinger M, Zhou R, Ishiyama A, Moore L, Maria P, Blevins N, Jackler R, Alyono J, Kveton J, Navaratnam D, Heller S, Lopez I, Grillet N, Jan T, Cheng A. Single-cell transcriptomic atlas reveals increased regeneration in diseased human inner ear balance organs. Nature Communications 2024, 15: 4833. PMID: 38844821, PMCID: PMC11156867, DOI: 10.1038/s41467-024-48491-y.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptome atlasInner ear hair cell lossNon-sensory cell typesCell regeneration in vivoVestibular schwannoma patientsTranscriptomic atlasHair cellsHair cell lossIGF-1 signalingHuman inner earMouse hair cellsCell trajectory analysisSchwannoma patientsDynamic gene expressionVestibular hair cellsPermanent hearingHair cell precursorsIGF-1Cell lossCell precursorsInner earRegenerative capacityMurine utriclesCell typesGene expression
2007
Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse
Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H. Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse. The Journal Of Membrane Biology 2007, 215: 49-56. PMID: 17415610, PMCID: PMC4154540, DOI: 10.1007/s00232-007-9004-5.Peer-Reviewed Original ResearchConceptsLateral membranesOuter hair cellsMouse outer hair cellsMotor protein activitySteady-state levelsKnockout experimentsProtein activityDevelopmental expressionMembrane tensionGenetic modificationConformational fluctuationsCellular mechanismsMotor moleculesMolecular motorsOnset of hearingMorphological estimatesProtein densityEarly maturationQuantitative polymerase chain reactionHair cellsVpkCmDevelopmental dataCochlear amplificationMaturationFull maturation