Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos
Xia R, Jian X, Rodrigue A, Bressler J, Boerwinkle E, Cui B, Daviglus M, DeCarli C, Gallo L, Glahn D, Knowles E, Moon J, Mosley T, Satizabal C, Sofer T, Tarraf W, Testai F, Blangero J, Seshadri S, González H, Fornage M. Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos. Alzheimer's & Dementia 2024, 20: 6070-6081. PMID: 38946675, PMCID: PMC11497725, DOI: 10.1002/alz.14082.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsLatino adultsAssociated to cognitive functionAdmixture mappingHispanic Community Health Study/Study of LatinosCognitive functionHispanic Community Health Study/StudyPrioritized single nucleotide polymorphismsGenetic variantsGenome-wide association studiesNon-Hispanic whitesFine-mapping analysisLoci harboring genesSample of BlackHispanic/Latino adultsPhosphoinositide lipid metabolismNeurocognitive measuresIndependent replicationAdmixture signalsUnique haplotypesGenetic architectureChromosomal regionsHarboring genesAssociation studiesNucleotide polymorphismsUsing rare genetic mutations to revisit structural brain asymmetry
Kopal J, Kumar K, Shafighi K, Saltoun K, Modenato C, Moreau C, Huguet G, Jean-Louis M, Martin C, Saci Z, Younis N, Douard E, Jizi K, Beauchamp-Chatel A, Kushan L, Silva A, van den Bree M, Linden D, Owen M, Hall J, Lippé S, Draganski B, Sønderby I, Andreassen O, Glahn D, Thompson P, Bearden C, Zatorre R, Jacquemont S, Bzdok D. Using rare genetic mutations to revisit structural brain asymmetry. Nature Communications 2024, 15: 2639. PMID: 38531844, PMCID: PMC10966068, DOI: 10.1038/s41467-024-46784-w.Peer-Reviewed Original ResearchConceptsCopy number variationsGenome-wide association studiesBrain asymmetryPlanum temporale asymmetryHemispheric functional specializationStructural brain asymmetryCopy number variation carriersBrain-related phenotypesFacial cuesWord recognitionBrain lateralizationHuman cognitive capacitiesPerspective takingCognitive operationsRight hemispherePattern-learning approachBrain organizationLateralized functionsSusceptible to deletionGenetic influencesCognitive capacityAssociation studiesAsymmetry patternsGenomic deletionsGene sets