2010
Bisphenol A interferes with synaptic remodeling
Hajszan T, Leranth C. Bisphenol A interferes with synaptic remodeling. Frontiers In Neuroendocrinology 2010, 31: 519-530. PMID: 20609373, PMCID: PMC2964437, DOI: 10.1016/j.yfrne.2010.06.004.Peer-Reviewed Original Research
2008
Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates
Leranth C, Hajszan T, Szigeti-Buck K, Bober J, MacLusky NJ. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 14187-14191. PMID: 18768812, PMCID: PMC2544599, DOI: 10.1073/pnas.0806139105.Peer-Reviewed Original ResearchConceptsSpine synapse formationNonhuman primate modelSynapse formationPrimate modelAbility of BPAPrefrontal cortexOvariectomized nonhuman primatesLimbic brain areasHuman BPA exposureRodent animal modelsLow exposure levelsBPA administrationDaily doseMale ratsSpine synapsesBPA exposureAnimal modelsBrain areasSynthetic xenoestrogenCognitive functionNonhuman primatesAdverse effectsExposure levelsPolycarbonate plasticsExposure measurements
2007
Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats
Leranth C, Szigeti-Buck K, MacLusky NJ, Hajszan T. Bisphenol A Prevents the Synaptogenic Response to Testosterone in the Brain of Adult Male Rats. Endocrinology 2007, 149: 988-994. PMID: 18048497, PMCID: PMC2275360, DOI: 10.1210/en.2007-1053.Peer-Reviewed Original ResearchConceptsAdult male ratsMedial prefrontal cortexMale ratsSpine synapsesCA1 hippocampal areaAsymmetric spine synapsesSham-operated animalsElectron microscopic stereologyImpairs synaptogenesisSynaptogenic actionsOvariectomized ratsHippocampal areaTestosterone supplementationTestosterone propionateEstrogen receptorExposure measurement dataOil vehicleCompensatory increaseIntact animalsSynthetic xenoestrogenPrefrontal cortexRatsHippocampusCastrated malesPotential mechanisms