The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis
MacLusky NJ, Hajszan T, Leranth C. The Environmental Estrogen Bisphenol A Inhibits Estradiol-Induced Hippocampal Synaptogenesis. Environmental Health Perspectives 2005, 113: 675-679. PMID: 15929888, PMCID: PMC1257590, DOI: 10.1289/ehp.7633.Peer-Reviewed Original ResearchConceptsEnvironmental BPA exposureHippocampal synapse formationDendritic spine synapsesEndogenous estrogen productionHuman exposureNormal sex differencesHippocampus-dependent memoryHippocampal synaptogenesisOvariectomized ratsPyramidal neuronsBPA doseCA1 areaEstrogen productionSpine synapsesBPA exposureSignificant inhibitory effectSynaptic remodelingHippocampal functionSynapse formationCognitive functionNormal agingRapid effectsInhibitory effectManufacture of plasticsDental prostheses