2015
Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus
Rojas-Rodriguez R, Lifshitz L, Bellve K, Min S, Pires J, Leung K, Boeras C, Sert A, Draper J, Corvera S, Moore Simas T. Human adipose tissue expansion in pregnancy is impaired in gestational diabetes mellitus. Diabetologia 2015, 58: 2106-2114. PMID: 26067361, PMCID: PMC4526585, DOI: 10.1007/s00125-015-3662-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipogenesisAdipose TissueAdiposityAdultBlood GlucoseCapillariesCross-Sectional StudiesDiabetes, GestationalFemaleGene Expression ProfilingGene Expression RegulationGlucose Tolerance TestHumansInsulin-Like Growth Factor Binding Protein 5Insulin-Like Growth Factor IInsulin-Like Growth Factor IINeovascularization, PhysiologicOligonucleotide Array Sequence AnalysisPregnancyReal-Time Polymerase Chain ReactionConceptsGestational diabetes mellitusNormal glucose toleranceDiabetes mellitusCapillary densityAdipocyte sizeType 2 diabetes mellitusMethodsThis cross-sectional studyCapillary growthEctopic lipid depositionIGF binding proteinNon-pregnant womenCross-sectional studyAdipose tissue expansionCaesarean deliveryGlucose tolerancePregnant womenInsulin resistanceAdipocyte hypertrophyAT expansionQuantitative real-time PCRReal-time PCRIGF-1Real-time PCR studiesAims/Lipid deposition
2013
A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast
Mulla MJ, Salmon JE, Chamley LW, Brosens JJ, Boeras CM, Kavathas PB, Abrahams VM. A Role for Uric Acid and the Nalp3 Inflammasome in Antiphospholipid Antibody-Induced IL-1β Production by Human First Trimester Trophoblast. PLOS ONE 2013, 8: e65237. PMID: 23762324, PMCID: PMC3675211, DOI: 10.1371/journal.pone.0065237.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntiphospholipidAntiphospholipid SyndromeBeta 2-Glycoprotein ICARD Signaling Adaptor ProteinsCarrier ProteinsCaspase 1Cell LineCytoskeletal ProteinsFemaleGene Expression RegulationHumansInflammasomesInterleukin-1betaMiceNLR Family, Pyrin Domain-Containing 3 ProteinPregnancyPregnancy Trimester, FirstProtein PrecursorsSignal TransductionToll-Like Receptor 4TrophoblastsUric AcidConceptsIL-1β productionIntrauterine growth restrictionIL-1β secretionAntiphospholipid syndromeIL-1β processingAntiphospholipid antibodiesIL-1βHuman first trimester trophoblast cell lineFirst trimester trophoblast cell lineUric acidNalp3/ASC inflammasomeHuman first trimester trophoblast cellsToll-like receptor 4Human first-trimester trophoblastsFirst trimester trophoblast cellsAnti-β2GPI AbsAdverse pregnancy outcomesAnti-β2GPI antibodiesRecurrent pregnancy lossTLR4-dependent mannerApoptosis-associated speck-like proteinMaternal-fetal interfaceFirst trimester trophoblastsSpeck-like proteinTrophoblast cell line