Featured Publications
The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ. The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice. Science 2011, 332: 478-484. PMID: 21393509, PMCID: PMC3104397, DOI: 10.1126/science.1199214.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAnimalsAnti-Inflammatory Agents, Non-SteroidalArthritis, ExperimentalCartilage, ArticularFemaleGranulinsHumansIntercellular Signaling Peptides and ProteinsLigandsMaleMiceMice, Inbred StrainsMice, KnockoutMice, TransgenicMiddle AgedProgranulinsProtein Interaction Domains and MotifsReceptors, Tumor Necrosis Factor, Type IReceptors, Tumor Necrosis Factor, Type IIRecombinant Fusion ProteinsRecombinant ProteinsSignal TransductionT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaYoung AdultConceptsInflammatory arthritisAdministration of progranulinAntagonist of TNFαCollagen-induced arthritisArthritis mouse modelPGRN-deficient miceNew potential therapeutic interventionsPotential therapeutic interventionsGrowth factor progranulinNecrosis factor receptorRheumatoid arthritisMouse modelArthritisTherapeutic interventionsProgranulinTNF receptorFactor receptorMiceReceptorsInflammationTissue repairTNFαIntracellular signalingAtsttrinTNFRAssociation Between Progranulin and Gaucher Disease
Jian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, Wang G, Chen Y, Liang F, Overkleeft HS, Saunders-Pullman R, Chan GL, Liu CJ. Association Between Progranulin and Gaucher Disease. EBioMedicine 2016, 11: 127-137. PMID: 27515686, PMCID: PMC5049935, DOI: 10.1016/j.ebiom.2016.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesAnimalsCase-Control StudiesDisease Models, AnimalEnzyme ActivationFemaleGaucher DiseaseGene FrequencyGenetic Association StudiesGenotypeHumansIntercellular Signaling Peptides and ProteinsLysosomesMaleMiceMice, KnockoutMiddle AgedMutationPhenotypePolymorphism, Single NucleotideProgranulinsProtein TransportConceptsGD patientsHealthy controlsGaucher diseaseGRN genePGRN KO miceSerum PGRN levelsPGRN-deficient miceHealthy control samplesSerum levelsPGRN levelsGaucher-like cellsKO miceTherapeutic effectRecombinant PGRNGeneral populationPatientsAnimal modelsBone marrowGBA1 geneLysosomal localizationProgranulin geneNull micePGRNDiseaseMice
2012
Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA
Lai Y, Yu X, Zhang Y, Tian Q, Song H, Mucignat M, Perris R, Samuels J, Krasnokutsky S, Attur M, Greenberg J, Abramson S, Di Cesare P, Liu C. Enhanced COMP catabolism detected in serum of patients with arthritis and animal disease models through a novel capture ELISA. Osteoarthritis And Cartilage 2012, 20: 854-862. PMID: 22595227, PMCID: PMC3389204, DOI: 10.1016/j.joca.2012.05.003.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsAntirheumatic AgentsArthritis, ExperimentalArthritis, RheumatoidCartilage Oligomeric Matrix ProteinCase-Control StudiesEnzyme-Linked Immunosorbent AssayExtracellular Matrix ProteinsFemaleGlycoproteinsHumansMaleMatrilin ProteinsMethotrexateMiceMice, TransgenicMiddle AgedOsteoarthritisRecombinant Fusion ProteinsSynovial FluidTumor Necrosis Factor-alphaYoung AdultConceptsCollagen-induced arthritisEnzyme-linked immunosorbent assayCapture enzyme-linked immunosorbent assayCOMP fragmentsRA patientsOA patientsRheumatoid arthritisRodent arthritis modelsTherapeutic response predictorsArthritis mouse modelSera of patientsTNF-transgenic miceTransgenic animal modelsEffects of interventionsNovel sandwich enzyme-linked immunosorbent assayAnimal disease modelsSandwich enzyme-linked immunosorbent assayDisease courseSerum levelsArthritis modelTNFα inhibitorsArthritic patientsCOMP levelsMurine modelResponse predictors
2008
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin
Luan Y, Kong L, Howell D, Ilalov K, Fajardo M, Bai X, Di Cesare P, Goldring M, Abramson S, Liu C. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis And Cartilage 2008, 16: 1413-1420. PMID: 18485748, PMCID: PMC2574789, DOI: 10.1016/j.joca.2008.03.017.Peer-Reviewed Original ResearchConceptsCartilage oligomeric matrix proteinADAMTS-7ADAMTS-12COMP degradationOA patientsOligomeric matrix proteinIL-1betaTNF-alphaHuman chondrocytesCartilage explantsCultured cartilage explantsFirst endogenous inhibitorsArthritic patientsTumor necrosisMatrix proteinsCOMP fragmentsPatientsEndogenous inhibitorDependent mannerOsteoarthritisADAMTS familyAntibodiesInhibitionCartilageChondrocytes
2006
ADAMTS‐7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein
Liu C, Kong W, Ilalov K, Yu S, Xu K, Prazak L, Fajardo M, Sehgal B, Di Cesare P, Liu C, Kong W, Ilalov K, Yu S, Xu K, Prazak L, Fajardo M, Sehgal B, Di Cesare P. ADAMTS‐7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein. The FASEB Journal 2006, 20: 988-990. PMID: 16585064, PMCID: PMC1483927, DOI: 10.1096/fj.05-3877fje.Peer-Reviewed Original ResearchMeSH KeywordsADAM ProteinsADAMTS7 ProteinAdultAgedAnimalsArthritis, RheumatoidBinding SitesCartilageCartilage Oligomeric Matrix ProteinExtracellular Matrix ProteinsGene Expression Regulation, EnzymologicGlycoproteinsHumansHydrogen-Ion ConcentrationMatrilin ProteinsMiceMiddle AgedProtein BindingRatsRNA, MessengerSynovial MembraneTwo-Hybrid System TechniquesUp-RegulationZincConceptsCartilage oligomeric matrix proteinMatrix proteinsEpidermal growth factor domainTwo-hybrid screenOligomeric matrix proteinGrowth factor domainRecombinant catalytic domainCatalytic domainRepeat domainFunctional domainsInteraction partnersADAMTS-7Factor domainAmino acidsEnzymatic activityProteinHigh expression
2005
Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip and Knee Arthroplasty
Di Cesare P, Chang E, Preston C, Liu C. Serum Interleukin-6 as a Marker of Periprosthetic Infection Following Total Hip and Knee Arthroplasty. Journal Of Bone And Joint Surgery 2005, 87: 1921-1927. PMID: 16140805, DOI: 10.2106/jbjs.d.01803.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overArthroplasty, Replacement, HipArthroplasty, Replacement, KneeBiomarkersBlood SedimentationCase-Control StudiesC-Reactive ProteinFemaleHumansInterleukin-6Leukocyte CountMaleMiddle AgedPredictive Value of TestsProspective StudiesProsthesis-Related InfectionsSensitivity and SpecificityStatistics, NonparametricConceptsSerum interleukin-6 levelsWhite blood cell countInterleukin-6 levelsErythrocyte sedimentation rateBlood cell countImplant-related problemsTotal hipTotal knee arthroplastyPeriprosthetic infectionSerum levelsNegative predictive valuePositive predictive valueKnee arthroplastyPredictive valueInterleukin-6Elevated serum interleukin-6 levelsC-reactive protein serum levelsTotal knee arthroplasty groupC-reactive protein levelsInterleukin-6 serum levelsKnee arthroplasty groupSerum interleukin-6Group of patientsProtein serum levelsC-reactive protein