2024
Association between Left Ventricular Geometry, Systolic Ejection Time, and Estimated Glomerular Filtration Rate in Ambulatory Patients with Preserved Left Ventricular Ejection Fraction
Goeddel L, Navarrete S, Waldron N, D’Amiano A, Faraday N, Lima J, Parikh C, Bandeen-Roche K, Hays A, Brown C. Association between Left Ventricular Geometry, Systolic Ejection Time, and Estimated Glomerular Filtration Rate in Ambulatory Patients with Preserved Left Ventricular Ejection Fraction. Cardiology 2024, 1-11. PMID: 39353411, DOI: 10.1159/000541725.Peer-Reviewed Original ResearchLeft ventricular ejection fractionTrans thoracic echocardiographyIncreased RWTRelative wall thicknessChronic kidney diseaseLeft ventricular ejection timeSubclinical systolic dysfunctionVentricular ejection fractionCardiac functionSystolic dysfunctionEjection fractionSystolic functionClinical outcomesPreserved left ventricular ejection fractionAmbulatory patientsAssociated with adverse clinical outcomesMeasures of LV geometryEjection timeAssociated with chronic kidney diseaseIncreased oddsMeasures of cardiac functionLV relative wall thicknessSubclinical cardiac dysfunctionIncreased odds of CKDOdds of chronic kidney diseaseUrine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies
Amatruda J, Katz R, Rebholz C, Sarnak M, Gutierrez O, Schrauben S, Greenberg J, Coresh J, Cushman M, Waikar S, Parikh C, Schelling J, Jogalekar M, Bonventre J, Vasan R, Kimmel P, Ix J, Shlipak M, Consortium C. Urine Biomarkers of Kidney Tubule Health and Risk of Incident CKD in Persons Without Diabetes: The ARIC, MESA, and REGARDS Studies. Kidney Medicine 2024, 6: 100834. PMID: 38826568, PMCID: PMC11141432, DOI: 10.1016/j.xkme.2024.100834.Peer-Reviewed Original ResearchAssociated with incident chronic kidney diseaseIncident chronic kidney diseaseChronic kidney diseaseUrine MCP-1Meta-analysisUrine biomarkersMCP-1A1M concentrationsMultivariable Cox proportional hazards regressionRisk of chronic kidney diseaseRisk of incident chronic kidney diseaseCox proportional hazards regressionIndependent of eGFRPrevalent chronic kidney diseaseCohort of adultsMeta-analysis of resultsA1MLong follow-up periodEarly chronic kidney diseaseFollow-up periodProportional hazards regressionUrine A1MARIC participantsREGARDS studyHealth markersPHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS.
Parikh C, Hernandez J. PHENOTYPING REPAIR AFTER ACUTE KIDNEY INJURY: PRECISION MEDICINE TO CLINICAL TRIALS. Transactions Of The American Clinical And Climatological Association 2024, 134: 37-46. PMID: 39135588, PMCID: PMC11316880.Peer-Reviewed Original ResearchConceptsAcute kidney injuryChronic kidney diseaseKidney injuryEpisodes of acute kidney injuryAssociated with long-term riskLong-term risk of readmissionLong-term sequelaeRepair biomarkersRisk of readmissionSubclinical inflammationPreclinical studiesUrine biomarkersResearch biopsiesDeceased donor kidneysClinical trialsKidney diseaseBlood pressureMedical managementDonor kidneysPragmatic clinical trialsKidney tissueTherapeutic developmentOrgan allocationPrecision medicineKidney
2023
Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial
Chen T, Estrella M, Appel L, Surapaneni A, Köttgen A, Obeid W, Parikh C, Grams M. Associations of Baseline and Longitudinal Serum Uromodulin With Kidney Failure and Mortality: Results From the African American Study of Kidney Disease and Hypertension (AASK) Trial. American Journal Of Kidney Diseases 2023, 83: 71-78. PMID: 37690632, DOI: 10.1053/j.ajkd.2023.05.017.Peer-Reviewed Original ResearchConceptsRisk of kidney failureChronic kidney diseaseAssociated with mortalityKidney diseaseKidney failureRisk of KFRTSerum uromodulinCohort of African American adultsReplacement therapyUromodulin levelsHigh riskUrine protein-creatinine ratioAfrican American adultsStored serum samplesGlomerular filtration rateBlood pressure goalsProtein-creatinine ratioAbstractText Label="RESULTS">Levels of uromodulinStudy of Kidney DiseaseAfrican American Study of Kidney DiseaseRandomized treatment groupsAssociation of baselineBaseline demographic factorsCox proportional hazardsPlasma Biomarkers and Incident CKD Among Individuals Without Diabetes
Le D, Chen J, Shlipak M, Ix J, Sarnak M, Gutierrez O, Schelling J, Bonventre J, Sabbisetti V, Schrauben S, Coca S, Kimmel P, Vasan R, Grams M, Parikh C, Coresh J, Rebholz C, Consortium C. Plasma Biomarkers and Incident CKD Among Individuals Without Diabetes. Kidney Medicine 2023, 5: 100719. PMID: 37841418, PMCID: PMC10568645, DOI: 10.1016/j.xkme.2023.100719.Peer-Reviewed Original ResearchSoluble urokinase plasminogen activator receptorKidney injury molecule-1Incident chronic kidney diseaseChronic kidney diseaseLevels of kidney injury molecule-1Development of kidney diseaseMonocyte chemoattractant protein-1Kidney diseaseTNFR-2TNFR-1Development of chronic kidney diseaseConcentrations of kidney injury molecule-1Odds of incident chronic kidney diseaseAssociated with incident chronic kidney diseaseTumor necrosis factor receptor 2Urokinase plasminogen activator receptorCases of incident CKDYears of follow-upTumor necrosis factor receptor 1AbstractText Label="PLAIN-LANGUAGE SUMMARYBaseline plasma biomarkersHuman cartilage glycoprotein-39Kidney disease progressionPlasminogen activator receptorChemoattractant protein-1
2016
Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study
Greenberg JH, Zappitelli M, Devarajan P, Thiessen-Philbrook HR, Krawczeski C, Li S, Garg AX, Coca S, Parikh CR. Kidney Outcomes 5 Years After Pediatric Cardiac Surgery: The TRIBE-AKI Study. JAMA Pediatrics 2016, 170: 1071-1078. PMID: 27618162, PMCID: PMC5476457, DOI: 10.1001/jamapediatrics.2016.1532.Peer-Reviewed Original ResearchConceptsLong-term kidney outcomesAcute kidney injuryChronic kidney diseasePediatric cardiac surgeryPerioperative acute kidney injuryPostoperative acute kidney injuryCardiac surgeryKidney diseaseKidney outcomesKidney injuryHigh short-term morbidityProspective multicenter cohort studySerum creatinine riseMulticenter cohort studyShort-term morbidityAge 1 monthOutcomes 5 yearsRenal outcomesPreoperative baselineCohort studyPediatric centersCardiopulmonary bypassCreatinine risePerson followPerson visits