2024
Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behavior
2023
Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers
Chen Y, Li C. Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers. Addiction Neuroscience 2023, 7: 100089. PMID: 37483686, PMCID: PMC10358306, DOI: 10.1016/j.addicn.2023.100089.Peer-Reviewed Original ResearchCue responsesMonetary incentive delay taskDistinct neural correlatesDistinct neural underpinningsIncentive delay taskNegative emotional statesMid-cingulate cortexMedial cortical regionsDrug cuesNeural underpinningsCue reactivityNeural correlatesSubjective urgeAlcohol expectanciesDelay taskEmotional statesLoss processingSensation seekingVentral striatumAlcohol drinkersAversive componentCortical regionsAversive responsesSubstance misusePotential subtypes
2007
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li CS, Sinha R. Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction. Neuroscience & Biobehavioral Reviews 2007, 32: 581-597. PMID: 18164058, PMCID: PMC2263143, DOI: 10.1016/j.neubiorev.2007.10.003.Peer-Reviewed Original ResearchConceptsInhibitory controlPrefrontal activityDrug seekingHabitual drug seekingCognitive inhibitory controlCompulsive drug seekingVentromedial prefrontal regionsFrontal-limbic dysfunctionStress-related cravingAnterior cingulate cortexStress regulationPsychological processesNeural underpinningsSalient stimuliStress processingPrefrontal regionsComponent processesStriatal responsesDrug use behaviorsCingulate cortexNeural systemsPsychostimulant dependenceUse behaviorsNeural pathwaysAddiction