Featured Publications
CAROTID ARTERY STENTING AND ANGIOPLASTY WITH PROTECTION IN PATIENTS AT HIGH-RISK FOR ENDARTERECTOMY: SAPPHIRE WORLDWIDE REGISTRY OUTCOMES
Harris K, Smolderen K, Mena-Hurtado C. CAROTID ARTERY STENTING AND ANGIOPLASTY WITH PROTECTION IN PATIENTS AT HIGH-RISK FOR ENDARTERECTOMY: SAPPHIRE WORLDWIDE REGISTRY OUTCOMES. Journal Of The American College Of Cardiology 2022, 79: 640. DOI: 10.1016/s0735-1097(22)01631-x.Peer-Reviewed Original ResearchGuideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions
Smolderen K, Romain G, Provance J, Scierka L, Mao J, Goodney P, Henke P, Sedrakyan A, Mena-Hurtado C. Guideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions. JACC Cardiovascular Interventions 2023, 16: 332-343. PMID: 36792257, PMCID: PMC10359106, DOI: 10.1016/j.jcin.2022.09.022.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyPeripheral vascular interventionsMedical therapyVascular interventionsEnzyme inhibitors/angiotensin receptor blockersVascular Quality Initiative registryAngiotensin receptor blockersLong-term mortalityRisk of amputationRisk of mortalityNational quality registryQuality improvement effortsAmputation outcomesAmputation riskMajor amputationAntiplatelet therapyCause mortalityReceptor blockersMean ageVascular careQuality registryObservational studyMortality riskHigh riskAmputation dataExamining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease
Grubman S, Algara M, Smolderen K, Luna P, Walenczyk K, Scierka L, Cleman J, Siddiqui W, Romain G, Mena‐Hurtado C. Examining Outcomes in Patients Admitted With Comorbid Peripheral Artery Disease and Microvascular Disease. Journal Of The American Heart Association 2024, 13: e030710. PMID: 38166496, PMCID: PMC10863818, DOI: 10.1161/jaha.123.030710.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseMajor adverse cardiac eventsAdverse cardiac eventsMicrovascular diseaseMinor amputationHospital mortalityCardiac eventsArtery diseaseNational Readmission DatabaseFurther prospective researchNumber of patientsCommon risk factorsMultiple logistic regressionMajor amputationBaseline factorsFinal cohortCox regressionAdverse outcomesPAD groupSecondary diagnosisRisk factorsAnnual admissionsObservational studyPrevalent conditionHigh risk
2024
Comparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease
Cleman J, Sierra J, Romain G, Capuano B, Scierka L, Callegari S, Jacque F, Peri-Okonny P, Nagpal S, Smolderen K, Mena-Hurtado C. Comparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease. Journal Of Vascular Surgery 2024, 80: 480-489.e5. PMID: 38608966, DOI: 10.1016/j.jvs.2024.04.016.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAll-cause mortalityLower extremity bypassPeripheral vascular interventionsComorbid chronic kidney diseaseLimb-threatening ischemiaComparison of mortalityPreference-sensitive treatment decisionsCox proportional hazards modelsRisk of deathInteraction termsProportional hazards modelLower-extremity bypassChronic kidney diseaseFine-Gray modelMortality riskVascular interventionsAmputationHazards modelOutcome dataFine-GrayAssociated with worse outcomesHigh riskKidney diseasePropensity score
2023
Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participants
2022
Predictors of Major Adverse Limb Events After Infrainguinal Bypass in Patients with Diabetes
Alameddine D, Satam K, Slade M, Wang H, Mena-Hurtado C, Turner J, Inzucchi S, Chaar C. Predictors of Major Adverse Limb Events After Infrainguinal Bypass in Patients with Diabetes. American Heart Journal 2022, 254: 241. DOI: 10.1016/j.ahj.2022.10.026.Peer-Reviewed Original ResearchMajor adverse limb eventsLower extremity revascularizationPeripheral artery diseaseAdverse limb eventsInfrainguinal bypassInsulin useDiabetes mellitusLimb eventsVascular Quality Initiative databaseHigher major amputationObjective Diabetes mellitusOutcomes of patientsAssociation of diabetesLower primary patencyMajor risk factorMajor amputationPrimary patencyExtremity revascularizationInsulin therapyKidney transplantArtery diseaseGlucose controlA1c controlRisk factorsHigh riskCAROTID ARTERY STENTING AND ANGIOPLASTY WITH PROTECTION IN PATIENTS AT HIGH-RISK FOR ENDARTERECTOMY: SAPPHIRE WORLDWIDE REGISTRY OUTCOMES ACROSS PATIENT SUBGROUPS
Harris K, Mena-Hurtado C, Smolderen K. CAROTID ARTERY STENTING AND ANGIOPLASTY WITH PROTECTION IN PATIENTS AT HIGH-RISK FOR ENDARTERECTOMY: SAPPHIRE WORLDWIDE REGISTRY OUTCOMES ACROSS PATIENT SUBGROUPS. Journal Of The American College Of Cardiology 2022, 79: 1812. DOI: 10.1016/s0735-1097(22)02803-0.Peer-Reviewed Original Research
2021
Guideline-Directed Medical Therapy in Patients with Chronic Kidney Disease Undergoing Peripheral Vascular Intervention
Jelani QU, Llanos-Chea F, Bogra P, Trejo-Paredes C, Huang J, Provance JB, Turner J, Anantha-Narayanan M, Sheikh AB, Smolderen KG, Mena-Hurtado C. Guideline-Directed Medical Therapy in Patients with Chronic Kidney Disease Undergoing Peripheral Vascular Intervention. American Journal Of Nephrology 2021, 52: 845-853. PMID: 34706363, DOI: 10.1159/000519484.Peer-Reviewed Original ResearchConceptsComorbid chronic kidney diseaseGuideline-directed medical therapyPeripheral vascular interventionsCritical limb ischemiaMedian odds ratioMedical therapyPrescription ratesVascular interventionsHigh riskUse of GDMTAdjusted median odds ratioVascular Quality Initiative databaseAngiotensin-converting enzyme inhibitorAngiotensin receptor blockersChronic kidney diseaseLower prescription ratesPoor clinical outcomeCKD groupCKD statusAntiplatelet therapyReceptor blockersLimb ischemiaLimb outcomesClinical outcomesMedical management
2020
Impact of atrial fibrillation on the outcomes of transcatheter mitral valve repair using MitraClip: a systematic review and meta-analysis
Shah S, Raj V, Abdelghany M, Mena-Hurtado C, Riaz S, Patel S, Wiener H, Chaudhuri D. Impact of atrial fibrillation on the outcomes of transcatheter mitral valve repair using MitraClip: a systematic review and meta-analysis. Heart Failure Reviews 2020, 26: 531-543. PMID: 33169339, DOI: 10.1007/s10741-020-10051-z.Peer-Reviewed Original ResearchConceptsTranscatheter mitral valve repairAtrial fibrillationMitral valve repairAF patientsCause mortalityMitral regurgitationValve repairSystematic reviewHeart failure hospitalizationHF hospitalizationHospital mortalityFailure hospitalizationCardiovascular mortalityCommon arrhythmiaProcedural failureInclusion criteriaHigh riskPatientsMitraClipMortalitySystematic searchGoogle ScholarHospitalizationRiskFibrillationOutcomes with catheter‐directed thrombolysis compared with anticoagulation alone in patients with acute deep venous thrombosis
Abraham B, Sedhom R, Megaly M, Saad M, Elbadawi A, Elgendy IY, Omer M, Narayanan MA, Mena‐Hurtado C, Pershad A, Shamoun F, Lalonde T, Attallah A. Outcomes with catheter‐directed thrombolysis compared with anticoagulation alone in patients with acute deep venous thrombosis. Catheterization And Cardiovascular Interventions 2020, 97: e61-e70. PMID: 32936517, DOI: 10.1002/ccd.29226.Peer-Reviewed Original ResearchConceptsAcute deep venous thrombosisCatheter-directed thrombolysisDeep venous thrombosisVenous patencyPostthrombotic syndromeVenous thrombosisManagement of DVTMajor bleedingHospital stayMean followCDT groupBlood transfusionAnticoagulationHigher oddsHigh riskLower riskPatientsSystematic reviewPatencyThromboembolismThrombolysisThrombosisSyndromeHigh rateRisk
2019
Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective
Ionescu CN, Altin SE, Mena-Hurtado C. Antiplatelet therapy for tibial balloon angioplasty: A clinical perspective. SAGE Open Medicine 2019, 7: 2050312119854579. PMID: 31210934, PMCID: PMC6545680, DOI: 10.1177/2050312119854579.Peer-Reviewed Original ResearchTibial balloon angioplastyCritical limb ischaemiaBalloon angioplastyAntiplatelet therapyLimb ischaemiaCritical limb ischaemia patientsNumber of patientsMultiple comorbiditiesPreclinical dataAngioplasty techniquesTherapeutic approachesHigh riskPost interventionAngioplastyClinical perspectiveTherapyIschaemiaPatientsShort durationComorbiditiesTrialsImportant role