Featured Publications
Risk profiles, access to care, and outcomes in Hispanics hospitalized for lower extremity peripheral artery disease
Luna P, Harris K, Castro-Dominguez Y, Algara M, Severiche-Mena C, Smolderen KG, Mena-Hurtado C. Risk profiles, access to care, and outcomes in Hispanics hospitalized for lower extremity peripheral artery disease. Journal Of Vascular Surgery 2022, 77: 216-224.e15. PMID: 36037965, DOI: 10.1016/j.jvs.2022.08.021.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseLower extremity peripheral artery diseaseNon-Hispanic whitesEmergency departmentPAD careArtery diseaseRisk factorsSevere peripheral artery diseaseChronic limb-threatening ischemiaRisk profileNational Inpatient Sample dataCardiovascular risk factorsLimb-threatening ischemiaPatients' sociodemographic characteristicsWorse clinical outcomesMultivariable logistic regressionAssociation of ethnicityLength of stayHealth care consumptionHealth care coveragePAD hospitalizationsPrior amputationEndovascular revascularizationED admissionRenal failureSecondary interventions following open vs endovascular revascularization for chronic limb threatening ischemia in the BEST-CLI trial
Conte M, Azene E, Doros G, Gasper W, Hamza T, Kashyap V, Guzman R, Mena-Hurtado C, Menard M, Rosenfield K, Rowe V, Strong M, Farber A. Secondary interventions following open vs endovascular revascularization for chronic limb threatening ischemia in the BEST-CLI trial. Journal Of Vascular Surgery 2024, 79: 1428-1437.e4. PMID: 38368997, DOI: 10.1016/j.jvs.2024.02.005.Peer-Reviewed Original ResearchIntention-to-treatBEST-CLIChronic limb-threatening ischemiaOpen bypassRe-interventionBEST-CLI trialCohort 1Limb-threatening ischemiaSecondary analysisCox regression modelsOpen armMultivariate Cox regression modelRegression modelsDuration of follow-upTrial cohortCohortAnalyzed dataRandomized trialsFollow-upReduced hazardEndovascular revascularizationCLTIInitial treatmentTrialsStudy endpointThe Vascular Quality Initiative assessment of the Bard Lifestent for the treatment of popliteal artery occlusive disease
Bertges D, Eldrup-Jorgensen J, Eskandari M, Hamdan A, Mena-Hurtado C, Mewissen M, Smith T, Woo E, Cronenwett J, Initiative S. The Vascular Quality Initiative assessment of the Bard Lifestent for the treatment of popliteal artery occlusive disease. Journal Of Vascular Surgery 2023, 78: 1489-1496.e1. PMID: 37648091, DOI: 10.1016/j.jvs.2023.08.122.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationChronic limb-threatening ischemiaTarget vessel revascularizationMajor adverse eventsLimb-threatening ischemiaPopliteal arteryLesion revascularizationMajor amputationVessel revascularizationHemodynamic successSecondary patencyAdverse eventsOcclusive diseaseProcedural successSingle-arm prospective studyProximal popliteal arterySustained clinical successPrimary efficacy outcomePrimary safety outcomeArtery occlusive diseaseComposite primary endpointPrimary-assisted patencyKaplan-Meier analysisSuperficial femoral arteryMajority of stents
2024
Competing risk analysis to estimate amputation incidence and risk in lower-extremity peripheral artery disease
Callegari S, Smolderen K, Cleman J, Mena-Hurtado C, Romain G. Competing risk analysis to estimate amputation incidence and risk in lower-extremity peripheral artery disease. Vascular Medicine 2024, 29: 496-506. PMID: 39219174, DOI: 10.1177/1358863x241268727.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAmputation riskTime-to-event analysisPeripheral arterial diseaseLower-extremity peripheral arterial diseaseCumulative incidence functionCompeting risk analysisAmputation incidenceAmputation dataMedicare claimsLimb-threatening ischemiaVascular Quality Initiative registryMortality riskOutcomes researchPeripheral vascular interventionsArtery diseaseAmputationVascular outcomesCox regressionRiskMortalityCohortVascular interventionsTime-to-event methodsPatientsSecondary interventions following open vs endovascular revascularization for chronic limb threatening ischemia in the BEST-CLI trial Presented at the 2023 Vascular Annual Meeting of the Society for Vascular Surgery, National Harbor, Maryland, June 14-17, 2023.
Conte M, Azene E, Doros G, Gasper W, Hamza T, Kashyap V, Guzman R, Mena-Hurtado C, Menard M, Rosenfield K, Rowe V, Strong M, Farber A. Secondary interventions following open vs endovascular revascularization for chronic limb threatening ischemia in the BEST-CLI trial Presented at the 2023 Vascular Annual Meeting of the Society for Vascular Surgery, National Harbor, Maryland, June 14-17, 2023. European Journal Of Vascular And Endovascular Surgery 2024, 67: e94-e95. DOI: 10.1016/j.ejvs.2024.05.027.Peer-Reviewed Original ResearchBEST-CLI trialChronic limb-threatening ischemiaLimb-threatening ischemiaSociety for Vascular SurgeryLong‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention
Callegari S, Romain G, Cleman J, Scierka L, Jacque F, Smolderen K, Mena‐Hurtado C. Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention. Journal Of The American Heart Association 2024, 13: e034477. PMID: 38761075, PMCID: PMC11179837, DOI: 10.1161/jaha.124.034477.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaPeripheral vascular interventionsHealth careLimb-threatening ischemiaMortality predictorsLong-term mortality riskMultidimensional risk factorsBody mass indexLong-term mortality predictorsImprove individualized careVascular interventionsIndividualized careAssisted careBiopsychosocial modelMortality riskCareMass indexRisk factorsMedical comorbiditiesRisk profileInterventionMortality rateChronic kidney diseaseMortalityPredictive variablesComparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease
Cleman J, Sierra J, Romain G, Capuano B, Scierka L, Callegari S, Jacque F, Peri-Okonny P, Nagpal S, Smolderen K, Mena-Hurtado C. Comparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease. Journal Of Vascular Surgery 2024, 80: 480-489.e5. PMID: 38608966, DOI: 10.1016/j.jvs.2024.04.016.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAll-cause mortalityLower extremity bypassPeripheral vascular interventionsComorbid chronic kidney diseaseLimb-threatening ischemiaComparison of mortalityPreference-sensitive treatment decisionsCox proportional hazards modelsRisk of deathInteraction termsProportional hazards modelLower-extremity bypassChronic kidney diseaseFine-Gray modelMortality riskVascular interventionsAmputationHazards modelOutcome dataFine-GrayAssociated with worse outcomesHigh riskKidney diseasePropensity scoreEvaluation of short-term mortality in patients with Medicare undergoing endovascular interventions for chronic limb-threatening ischemia
Cleman J, Romain G, Callegari S, Scierka L, Jacque F, Smolderen K, Mena-Hurtado C. Evaluation of short-term mortality in patients with Medicare undergoing endovascular interventions for chronic limb-threatening ischemia. Vascular Medicine 2024, 29: 172-181. PMID: 38334045, DOI: 10.1177/1358863x231224335.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaPeripheral vascular interventionsAssisted careLimb-threatening ischemiaCongestive heart failureFunctional status variablesCrude mortality ratePredictive variablesMortality rateStatus variablesRandom survival forest modelShort-term mortalityStage 5 chronic kidney diseaseQuality InitiativeRandom survival forestTreatment conversionMedical comorbiditiesShort-term outcomesHarrell's C-indexVascular Quality InitiativeCareDementiaInterventionMortalityRisk stratificationInsulin Requirement and Infrainguinal Bypass Outcomes in Patients with Peripheral Arterial Disease
Alameddine D, Satam K, Slade M, Wang H, Mena-Hurtado C, Turner J, Inzucchi S, Ochoa Chaar C. Insulin Requirement and Infrainguinal Bypass Outcomes in Patients with Peripheral Arterial Disease. Annals Of Vascular Surgery 2024, 102: 25-34. PMID: 38307234, DOI: 10.1016/j.avsg.2023.11.044.Peer-Reviewed Original ResearchInsulin-requiring diabetes mellitusPeripheral arterial diseaseDiabetes mellitusInfrainguinal bypassInsulin requirementsArtery diseaseRisk of MALEBypass surgeryImpact of insulin useRates of primary patencyVascular Quality Initiative databaseOutcomes of patientsPeripheral arterial bypass surgeryInfrainguinal bypass surgeryStratification of patientsCrude rateElevated hemoglobin A1cArtery bypass surgeryAssociation of DMChronic limb-threatening ischemiaIncreased risk of MALEVascular Quality InitiativeLower extremity revascularizationAdverse limb eventsLimb-threatening ischemia
2023
The Impact of Ejection Fraction on Major Adverse Limb Events after Lower Extremity Revascularization
Jamil Y, Huttler J, Alameddine D, Wu Z, Zhuo H, Mena-Hurtado C, Velazquez E, Guzman R, Ochoa Chaar C. The Impact of Ejection Fraction on Major Adverse Limb Events after Lower Extremity Revascularization. Annals Of Vascular Surgery 2023, 98: 210-219. PMID: 37802138, DOI: 10.1016/j.avsg.2023.08.009.Peer-Reviewed Original ResearchMajor adverse limb eventsReduced ejection fractionLower extremity revascularizationPeripheral arterial diseaseMALE-free survivalAdverse limb eventsCoronary artery diseaseEjection fractionExtremity revascularizationArtery diseaseLimb eventsChronic limb-threatening ischemiaLimb-threatening ischemiaTricuspid valve regurgitationKaplan-Meier curvesElectronic medical recordsMajor amputationSevere mitralDiastolic dysfunctionEchocardiographic findingsTransthoracic echocardiogramHeart failureValve regurgitationArterial diseaseSingle centerSecondary Interventions Following Open vs Endovascular Revascularization for Chronic Limb-threatening Ischemia in the BEST-CLI Trial
Conte M, Azene E, Gasper W, Guzman R, Hamza T, Kashyap V, Mena-Hurtado C, Menard M, Rosenfield K, Rowe V, Farber A. Secondary Interventions Following Open vs Endovascular Revascularization for Chronic Limb-threatening Ischemia in the BEST-CLI Trial. Journal Of Vascular Surgery 2023, 77: e80-e81. DOI: 10.1016/j.jvs.2023.03.091.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaBEST-CLI trialLimb-threatening ischemiaBEST-CLIEndovascular revascularizationComparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative
Cleman J, Romain G, Grubman S, Guzman R, Smolderen K, Mena-Hurtado C. Comparison of lower extremity bypass and peripheral vascular intervention for chronic limb-threatening ischemia in the Medicare-linked Vascular Quality Initiative. Journal Of Vascular Surgery 2023, 78: 745-753.e6. PMID: 37207790, PMCID: PMC10964324, DOI: 10.1016/j.jvs.2023.05.015.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaLower extremity bypassPeripheral vascular interventionsVascular Quality InitiativeLimb-threatening ischemiaCause mortalityRisk of deathExtremity bypassVascular interventionsQuality InitiativeCox proportional hazards regressionKaplan-Meier survival curvesProportional hazards regressionOverall mean ageLogistic regression modelsComparative effectiveness researchKnee poplitealMedicare registryInfrapopliteal arteriesHazards regressionMean ageThirty-dayHispanic ethnicityOutcome dataTreatment groups
2022
Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia
Farber A, Menard M, Conte M, Kaufman J, Powell R, Choudhry N, Hamza T, Assmann S, Creager M, Cziraky M, Dake M, Jaff M, Reid D, Siami F, Sopko G, White C, van Over M, Strong M, Villarreal M, McKean M, Azene E, Azarbal A, Barleben A, Chew D, Clavijo L, Douville Y, Findeiss L, Garg N, Gasper W, Giles K, Goodney P, Hawkins B, Herman C, Kalish J, Koopmann M, Laskowski I, Mena-Hurtado C, Motaganahalli R, Rowe V, Schanzer A, Schneider P, Siracuse J, Venermo M, Rosenfield K. Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia. New England Journal Of Medicine 2022, 387: 2305-2316. PMID: 36342173, DOI: 10.1056/nejmoa2207899.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaMajor adverse limb eventsAdverse limb eventsPrimary outcome eventGreat saphenous veinEndovascular groupSurgical groupSurgical revascularizationEndovascular therapySaphenous veinLimb eventsAdequate greater saphenous veinInfrainguinal peripheral artery diseaseChronic limb threatening ischemiaAlternative bypass conduitLimb threatening ischemiaLimb-threatening ischemiaPeripheral artery diseaseSaphenous vein conduitsRisk of amputationAdverse eventsLimb outcomesArtery diseasePrimary outcomeBypass conduitAssociation of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide
Harris KM, Mena-Hurtado C, Burg MM, Vriens PW, Heyligers J, Smolderen KG. Association of depression and anxiety disorders with outcomes after revascularization in chronic limb-threatening ischemia hospitalizations nationwide. Journal Of Vascular Surgery 2022, 77: 480-489. PMID: 36115521, DOI: 10.1016/j.jvs.2022.09.008.Peer-Reviewed Original ResearchConceptsLength of stayChronic limb-threatening ischemiaAnxiety disorder diagnosisAssociation of depressionRevascularization cohortMajor amputationDisorder diagnosisSurgical revascularizationEndovascular revascularizationHigher oddsLonger median LOSMedian LOSLonger LOSAnxiety disordersDocumentation of depressionPeripheral artery diseaseLimb-threatening ischemiaRisk of amputationNational Inpatient SamplePatients' sociodemographic dataHigher median costArtery diseaseIllness severityPsychiatric comorbidityComorbid depressionMajor Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative
Kim TI, Loh S, DeWan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Ochoa Chaar CI. Major Adverse Limb Events Among Patients with Premature Peripheral Artery Disease Compared with Those at the Common Age Undergoing Revascularization in the Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 87: 188-197. PMID: 35926786, DOI: 10.1016/j.avsg.2022.07.007.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsChronic limb-threatening ischemiaLower extremity revascularizationAdverse limb eventsVascular Quality InitiativePeripheral artery diseaseYears of ageCommon ageLimb eventsArtery diseaseOutcomes of patientsLimb-threatening ischemiaGroup of patientsInsulin-dependent diabetesProportional hazards regressionQuality InitiativeUndergoing revascularizationMedical optimizationCurrent smokersD diseaseExtremity revascularizationPatient agePatients 60Medical therapyHazards regression
2020
Seasonal variation in U.S. hospitalizations for chronic limb‐threatening ischemia
Altin SE, Kim YG, Aronow HD, Armstrong EJ, Goldsweig AM, Dardik A, Lanksy AJ, Mena‐Hurtado C, Abbott JD. Seasonal variation in U.S. hospitalizations for chronic limb‐threatening ischemia. Catheterization And Cardiovascular Interventions 2020, 96: 1473-1480. PMID: 32902126, DOI: 10.1002/ccd.29261.Peer-Reviewed Original ResearchConceptsCritical limb-threatening ischemiaLimb-threatening ischemiaNational Inpatient SampleMinor amputationChronic limb-threatening ischemiaUtilization Project National Inpatient SampleProvider education effortsCoronary artery diseaseAmputation rateHospital mortalityImportant comorbidityDiabetic statusOverall cohortSecondary outcomesArtery diseaseHospital admissionPrimary outcomeHospitalization incidenceU.S. hospitalizationsDiagnosis codesInpatient SampleHigher oddsAdmission seasonHealthcare costsMortality rateThe Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia
Kim TI, Mena C, Sumpio BE. The Role of Lower Extremity Amputation in Chronic Limb-Threatening Ischemia. International Journal Of Angiology 2020, 29: 149-155. PMID: 32904807, PMCID: PMC7458760, DOI: 10.1055/s-0040-1710075.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaImproved limb salvage ratesChronic limb threatening ischemiaRole of amputationLimb salvage rateLimb threatening ischemiaLimb-threatening ischemiaPeripheral artery diseaseLower Extremity AmputationMajor amputationPrimary amputationArtery diseaseLimb salvageSalvage rateExtremity amputationImproved careLimb lossSevere formMultidisciplinary teamAmputationRevascularizationIschemiaPatientsHigh rateSalvage