2024
National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults
Wang Y, Leo-Summers L, Vander Wyk B, Davis-Plourde K, Gill T, Becher R. National Estimates of Short- and Longer-Term Hospital Readmissions After Major Surgery Among Community-Living Older Adults. JAMA Network Open 2024, 7: e240028. PMID: 38416499, PMCID: PMC10902728, DOI: 10.1001/jamanetworkopen.2024.0028.Peer-Reviewed Original ResearchConceptsCenters for Medicare & Medicaid ServicesFee-for-serviceMedicare Advantage beneficiariesHospital readmissionUS residentsNational Health and Aging Trends Study dataCommunity-living older adultsProspective longitudinal cohort studyCommunity-living participantsRate of hospital readmissionLikelihood of hospital readmissionPopulation-based estimatesNationally representative estimatesSex-adjusted modelsCommunity-livingData linkageGeriatric conditionsMedicaid ServicesOlder personsOlder adultsMain OutcomesNational estimatesRepresentative estimatesData analysisCohort studyLongitudinal Care Network Changes and Associated Healthcare Utilization Among Care Recipients
Liu R, Vander Wyk B, Quiñones A, Allore H. Longitudinal Care Network Changes and Associated Healthcare Utilization Among Care Recipients. Research On Aging 2024, 46: 327-338. PMID: 38261524, PMCID: PMC11472584, DOI: 10.1177/01640275241229162.Peer-Reviewed Original ResearchSkilled-nursing facilityCare recipientsNational Health and Aging Trends StudyGeneralized estimating equation modelsCenters for MedicareLikelihood of hospitalizationMedicaid Services dataCaregiver networkUnpaid caregiversHealthcare utilizationTrends StudyAssociated healthcare utilizationOlder adultsCaregiversRisk ratioSurvey wavesService dataCareHospitalAssociationAdmissionMedicareMedicaidAdultsEquation modeling
2023
A Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries—Differences by Chronic Disease and Race/Ethnicity
Quiñones A, McAvay G, Vander Wyk B, Han L, Nagel C, Allore H. A Joint Model for Disability, Self-Rated Health, and Mortality Among Medicare Beneficiaries—Differences by Chronic Disease and Race/Ethnicity. Journal Of Aging And Health 2023, 36: 642-653. PMID: 37879084, PMCID: PMC11446605, DOI: 10.1177/08982643231210027.Peer-Reviewed Original ResearchPoor self-rated healthSelf-rated healthHigher oddsADL disabilityHip fractureAging Trends Study dataOlder adultsConcurrent riskPatient-centered outcomesLongitudinal logistic regression modelsLogistic regression modelsRace/ethnicityKidney diseaseChronic diseasesNational HealthDaily livingMortalityHealth declineOddsDisabilityHispanic respondentsDementiaDiseaseRiskWide variabilityDectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
Kumar A, Wang J, Esterly A, Radcliffe C, Zhou H, Wyk B, Allore H, Tsang S, Barakat L, Mohanty S, Zhao H, Shaw A, Zapata H. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging. Aging 2023, 15: 7866-7908. PMID: 37606991, PMCID: PMC10497004, DOI: 10.18632/aging.204927.Peer-Reviewed Original ResearchConceptsDectin-1 stimulationDendritic cellsHIV-positive older adultsOlder adultsDectin-1 functionDistinct immune signaturesDistinct inflammatory signatureMonocytes of HIVCohort of HIVIFN-α productionPro-inflammatory environmentIFN-γ responsesPro-inflammatory phenotypeInnate immune receptorsDistinct gene signaturesStimulation of monocytesInflammatory signatureImmune signaturesHIV infectionIL-12Macrophage signatureCytokine productionIL-6Cytokine increaseHIVAssociations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study
Monin J, McAvay G, Zang E, Vander Wyk B, Carrión C, Allore H. Associations between dementia staging, neuropsychiatric behavioral symptoms, and divorce or separation in late life: A case control study. PLOS ONE 2023, 18: e0289311. PMID: 37585365, PMCID: PMC10431668, DOI: 10.1371/journal.pone.0289311.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioAlzheimer's Disease Research CenterAgitation/aggressionDepression/dysphoriaCase-control studyElation/euphoriaNational Alzheimer's Coordinating CenterDisease Research CenterBehavioral symptomsDivorce/separationOlder adultsCoordinating CenterDementia stagingConditional logistic regressionStages of dementiaCase/control statusInitial visitOdds ratioIndividual symptomsNPI scoresStandardized clinical informationClinical informationMarried casesGreater oddsControl studyPlatelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2022
Development and validation of a prediction model for persistent functional impairment among older ICU survivors
Ferrante LE, Murphy TE, Leo‐Summers L, O'Leary JR, Vander Wyk B, Pisani MA, Gill TM. Development and validation of a prediction model for persistent functional impairment among older ICU survivors. Journal Of The American Geriatrics Society 2022, 71: 188-197. PMID: 36196998, PMCID: PMC9870848, DOI: 10.1111/jgs.18075.Peer-Reviewed Original ResearchConceptsPersistent functional impairmentICU hospitalizationFunctional impairmentValidation cohortICU admissionDevelopment cohortOlder Intensive Care Unit SurvivorsIntensive care unit survivorsOlder adultsOlder ICU survivorsMonths of dischargeHigh-risk survivorsCommunity-living participantsGood calibrationHospital lengthICU survivorsCritical illnessMedian agePrior hospitalizationFunctional recoveryNational HealthProbable dementiaHospitalizationHigh riskDepressive symptomsThe Contribution of Chronic Conditions to Hospitalization, Skilled Nursing Facility Admission, and Death: Variation by Race
Quiñones AR, McAvay GJ, Peak KD, Vander Wyk B, Allore HG. The Contribution of Chronic Conditions to Hospitalization, Skilled Nursing Facility Admission, and Death: Variation by Race. American Journal Of Epidemiology 2022, 191: 2014-2025. PMID: 35932162, PMCID: PMC10144669, DOI: 10.1093/aje/kwac143.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsChronic conditionsFacility admissionMedicare beneficiariesCostly health care utilizationHealth care utilizationRacial differencesNon-Hispanic blacksWhite Medicare beneficiariesAverage attributable fractionHealth-related outcomesImportant health-related outcomesNon-Hispanic White older adultsWhite older adultsAging Trends StudyMultimorbidity burdenRenal morbidityOngoing careAttributable fractionNational HealthCardiovascular conditionsOlder adultsImportant markerHospitalization
2019
Chronic Conditions, Medically Supportive Care Partners, And Functional Disability Among Cognitively Impaired Adults
Van Ness PH, Vroomen J, Leo-Summers L, Vander Wyk B, Allore HG. Chronic Conditions, Medically Supportive Care Partners, And Functional Disability Among Cognitively Impaired Adults. Innovation In Aging 2019, 3: igz018. PMID: 31286072, PMCID: PMC6604743, DOI: 10.1093/geroni/igz018.Peer-Reviewed Original ResearchChronic kidney diseaseFunctional disabilityChronic conditionsCare partnersKidney diseaseCognitive impairmentAging Trends Study dataPotential effect modificationMultimorbid older adultsMedicaid Services dataComplex survey designHeart failurePrescribed medicationsProspective studyEffect modificationNational HealthDoctor visitsMedicare claimsDaily livingMedicare beneficiariesRepresentative cohortSociodemographic informationImpaired adultsCare recipientsOlder adultsSociodemographic Factors and Characteristics of Caregivers as Determinants of Skilled Nursing Facility Admissions When Modeled Jointly With Functional Limitations
Jørgensen TSH, Allore H, MacNeil Vroomen JL, Wyk BV, Agogo GO. Sociodemographic Factors and Characteristics of Caregivers as Determinants of Skilled Nursing Facility Admissions When Modeled Jointly With Functional Limitations. Journal Of The American Medical Directors Association 2019, 20: 1599-1604.e4. PMID: 30902676, PMCID: PMC7444598, DOI: 10.1016/j.jamda.2019.01.154.Peer-Reviewed Original ResearchConceptsSkilled nursing facility admissionsNursing facility admissionsSNF admissionCharacteristics of caregiversFunctional limitationsSociodemographic factorsCaregiver characteristicsPartner caregiversFacility admissionHigh-risk populationImpact of caregiversNon-Hispanic whitesAging Trends StudyRace/ethnicityNational HealthStudy populationAdmissionLongitudinal changesMedicaid ServicesOlder adultsFuture interventionsEffect estimatesCaregiversLower hazardOlder Americans