2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefits
2023
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trialsEffect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Esserman D, Irwin M, Ferrucci L. Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer. JAMA Network Open 2023, 6: e2326463. PMID: 37526937, PMCID: PMC10394582, DOI: 10.1001/jamanetworkopen.2023.26463.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyAerobic exercise interventionAttention control armExercise intervention armExercise interventionOvarian cancerControl armIntervention armSecondary analysisCIPN symptomsPeripheral neuropathyLifestyle StudyTreatment of CIPNModerate-intensity aerobic exerciseStandard oncology careEffects of exerciseSevere adverse effectsBetween-group differencesAmerican Cancer SocietyQuality of lifeAttention controlCIPN severityPrimary outcomeOncology careAerobic exerciseRandomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomenA review of the impact of energy balance on triple-negative breast cancer
Akingbesote N, Owusu D, Liu R, Cartmel B, Ferrucci L, Zupa M, Lustberg M, Sanft T, Blenman K, Irwin M, Perry R. A review of the impact of energy balance on triple-negative breast cancer. JNCI Monographs 2023, 2023: 104-124. PMID: 37139977, DOI: 10.1093/jncimonographs/lgad011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTriple-negative breast cancerInterventional studyBreast cancerCancer treatmentClinical interventional studyClinical observationalImmune activationCancer outcomesCancer careClinical studiesOverall healthEnergy intakeNarrative reviewCancer cellsEnergy expenditureCancerTreatmentEnergy balanceOutcomesExerciseReviewDetrimental effectsImmunotherapyStudyIntakeA qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers
Pichardo M, Irwin M, Sanft T, Ferrucci L, Ginader A, Nguyen T, Esserman D, Cartmel B, Molina Y. A qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers. Supportive Care In Cancer 2023, 31: 111. PMID: 36633678, PMCID: PMC9912693, DOI: 10.1007/s00520-022-07539-9.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsOncology healthcare providersCancer survivorsLifestyle behaviorsHealthcare providersGeneric messagingEvidence-based knowledgeFemale breast cancer survivorsHealthcare provider counselingHealthy lifestyle guidelinesPatient-level barriersHealthy lifestyle behaviorsLifestyle guidelinesProvider counselingLifestyle factorsOncology careCancer outcomesBreast cancerConsistency of evidenceCurrent evidenceAvailable evidenceSurvivorsCancer diagnosisLevel barriersCancer
2022
Exercise adherence in a randomized controlled trial of exercise on quality of life in ovarian cancer survivors
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Irwin M, Ferrucci L. Exercise adherence in a randomized controlled trial of exercise on quality of life in ovarian cancer survivors. Journal Of Cancer Survivorship 2022, 17: 535-543. PMID: 36550261, PMCID: PMC10038915, DOI: 10.1007/s11764-022-01325-6.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsMin/weekCancer survivorsExercise goalsCancer recurrenceCounseling sessionsSession attendanceExercise adherenceHigher baseline activity levelsWeekly exercise durationTrial of exerciseMean exercise timeVigorous-intensity exerciseBaseline activity levelsQuality of lifeMore counseling sessionsExercise interventionExercise durationWeek exerciseLifestyle StudyExercise timeOvarian cancerNumber of sessionsCounseling intensitySurvivorsEffect of exercise on body composition among women with ovarian cancer
Cao A, Cartmel B, Li FY, Gottlieb LT, Harrigan M, Ligibel JA, Gogoi R, Schwartz PE, Irwin ML, Ferrucci LM. Effect of exercise on body composition among women with ovarian cancer. Journal Of Cancer Survivorship 2022, 17: 1386-1396. PMID: 35377104, PMCID: PMC9530065, DOI: 10.1007/s11764-022-01207-x.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryOvarian cancer survivorsAerobic exercise interventionEffects of exerciseCancer survivorsOvarian cancerExercise interventionBody compositionSix-month aerobic exercise interventionBone mineral densityBetween-group differencesBody fat percentageLean body massX-ray absorptiometrySecondary outcomesStudy armsAerobic exerciseLifestyle StudyMineral densityHigh riskCancerSurvivorsFat percentageWomenResultsOn average
2021
Effect of healthy diet and exercise on chemotherapy completion rate in women with breast cancer: The Lifestyle, Exercise and Nutrition Early after Diagnosis (LEANer) study: Study protocol for a randomized clinical trial
Sanft T, Harrigan M, Cartmel B, Ferrucci LM, Li FY, McGowan C, Zupa M, Nguyen TH, Ligibel J, Neuhouser ML, Hershman DL, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Irwin ML. Effect of healthy diet and exercise on chemotherapy completion rate in women with breast cancer: The Lifestyle, Exercise and Nutrition Early after Diagnosis (LEANer) study: Study protocol for a randomized clinical trial. Contemporary Clinical Trials 2021, 109: 106508. PMID: 34274495, PMCID: PMC10424280, DOI: 10.1016/j.cct.2021.106508.Peer-Reviewed Original ResearchConceptsChemotherapy completion rateTreatment-related side effectsPhysical activity guidelinesBreast cancerActivity guidelinesCancer survivorsSide effectsWorld Cancer Research FundUsual care control groupCompletion ratesEndocrine therapy adherenceCare control groupHealthy lifestyle interventionRandomized clinical trialsPatient reported outcomesPhysical activity interventionsBreast cancer treatmentAmerican Cancer SocietyBreast cancer prognosisCancer Research FundElectronic medical recordsOncology nutritionTreating oncologistSecondary endpointsChemotherapy sessionRandomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC)
Cartmel B, Hughes M, Ercolano EA, Gottlieb L, Li F, Zhou Y, Harrigan M, Ligibel JA, von Gruenigen VE, Gogoi R, Schwartz PE, Risch HA, Lu L, Irwin ML. Randomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC). Gynecologic Oncology 2021, 161: 587-594. PMID: 33773809, PMCID: PMC8085084, DOI: 10.1016/j.ygyno.2021.02.036.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsCES-D scoresCancer survivorsOvarian cancerDepressive symptomatologyAC armStage III/IV ovarian cancerBaseline CES-D scoreTrial of exerciseEpidemiologic Studies Depression ScaleOvarian cancer patientsEffects of exerciseSix-month changesPrevalent mental disordersLower depressive symptomsExercise armSerum BrainNeurotrophin factorRandomized trialsNeurotrophic factorCancer patientsLifestyle StudyDepression ScalePhysical activityDepressive symptoms
2020
Skin carotenoids are inversely associated with adiposity in breast cancer survivors
Cartmel B, Anderson C, Irwin ML, Harrigan M, Sanft T, Li F, Gellermann W, Ermakov IV, Ferrucci LM. Skin carotenoids are inversely associated with adiposity in breast cancer survivors. Nutrition Research 2020, 79: 77-86. PMID: 32650223, PMCID: PMC7409553, DOI: 10.1016/j.nutres.2020.05.012.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsSkin carotenoid scoreUsual care groupCancer survivorsSkin carotenoidsBody fatCare groupSerum biomarkersAdiposity measuresLog C-reactive protein levelsBaseline percent body fatObese breast cancer survivorsC-reactive protein levelsDual-energy X-ray absorptiometryStrong associationBreast cancer patientsWeight loss trialStudy of overweightTotal body fatPercent body fatX-ray absorptiometryLog leptinPoor outcomeCancer patientsHip circumference
2018
Concordance of cancer registry and self-reported race, ethnicity, and cancer type: a report from the American Cancer Society’s studies of cancer survivors
Layne TM, Ferrucci LM, Jones BA, Smith T, Gonsalves L, Cartmel B. Concordance of cancer registry and self-reported race, ethnicity, and cancer type: a report from the American Cancer Society’s studies of cancer survivors. Cancer Causes & Control 2018, 30: 21-29. PMID: 30392148, DOI: 10.1007/s10552-018-1091-3.Peer-Reviewed Original ResearchLymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity
Iyer NS, Cartmel B, Friedman L, Li F, Zhou Y, Ercolano E, Harrigan M, Gottlieb L, McCorkle R, Schwartz PE, Irwin ML. Lymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity. Cancer 2018, 124: 1929-1937. PMID: 29437202, DOI: 10.1002/cncr.31239.Peer-Reviewed Original ResearchConceptsLower limb lymphedemaOvarian cancer survivorsCancer survivorsSelf-report questionnairesSide effectsSpecialist evaluationCancer treatmentDiagnostic methodsRandomized exercise interventionTrial of exerciseBody mass indexPhysical activity recommendationsEffects of exerciseOvarian cancer treatmentGynecologic cancer treatmentLymphedema prevalenceLymphedema specialistExercise groupExercise interventionDifferent diagnostic methodsMass indexBaseline prevalenceActivity recommendationsOvarian cancerLimb lymphedema
2017
Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women’s Activity and Lifestyle Study in Connecticut (WALC)
Zhou Y, Cartmel B, Gottlieb L, Ercolano EA, Li F, Harrigan M, McCorkle R, Ligibel JA, von Gruenigen VE, Gogoi R, Schwartz PE, Risch HA, Irwin ML. Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women’s Activity and Lifestyle Study in Connecticut (WALC). Journal Of The National Cancer Institute 2017, 109: djx072. PMID: 30053074, PMCID: PMC6515522, DOI: 10.1093/jnci/djx072.Peer-Reviewed Original ResearchConceptsCancer-related fatigueOvarian cancer survivorsOvarian cancerCancer survivorsExercise interventionPhysical HRQoLCommunity-based exercise programSix-month RCTHealth-related qualityPrimary care providersTreatment side effectsGroup differencesSix-month assessmentQuality of lifeExercise armOverall survivalHigher HRQoLExercise programMental HRQOLRandomized trialsLifestyle StudyControl armFatigue scoresHRQoLPhysical activityPredictors of tanning dependence in white non‐Hispanic females and males
Cartmel B, Bale AE, Mayne ST, Gelernter JE, DeWan AT, Spain P, Leffell DJ, Pagoto S, Ferrucci LM. Predictors of tanning dependence in white non‐Hispanic females and males. Journal Of The European Academy Of Dermatology And Venereology 2017, 31: 1223-1228. PMID: 28129487, PMCID: PMC5522341, DOI: 10.1111/jdv.14138.Peer-Reviewed Original ResearchConceptsEarly-onset basal cell carcinomaCase-control studyBasal cell carcinomaWhite non-Hispanic femalesSymptoms of dependenceCell carcinomaNon-Hispanic femalesAlcohol dependenceMental disordersAppropriate interventionsHost factorsNon-HispanicsStatistical ManualMultivariate modelIndoor tanningSignificant predictorsOnline surveyFourth EditionPredictorsEuropean ancestryQuestionnaireEye openerEye colorParticipantsCarcinoma
2016
Health-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors — I
Zhou Y, Irwin ML, Ferrucci LM, McCorkle R, Ercolano EA, Li F, Stein K, Cartmel B. Health-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors — I. Gynecologic Oncology 2016, 141: 543-549. PMID: 27072805, PMCID: PMC4913461, DOI: 10.1016/j.ygyno.2016.04.006.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsGreater symptom burdenAmerican Cancer Society's StudyHealth-related qualityCancer survivorsSymptom burdenDisease recurrencePhysical functioningTwo yearsOne-yearPredictors of HRQOLNumber of comorbiditiesHigher disease stagePhysical HRQoL scoresPoor mental functioningSubset of participantsMental health issuesMental functioningMore comorbiditiesHRQoL scoresClinical factorsLower HRQoLDisease stageHRQoL dataSecondary data analysisHealth information needs and preferences in relation to survivorship care plans of long-term cancer survivors in the American Cancer Society’s Study of Cancer Survivors-I
Playdon M, Ferrucci LM, McCorkle R, Stein KD, Cannady R, Sanft T, Cartmel B. Health information needs and preferences in relation to survivorship care plans of long-term cancer survivors in the American Cancer Society’s Study of Cancer Survivors-I. Journal Of Cancer Survivorship 2016, 10: 674-685. PMID: 26744339, PMCID: PMC5032143, DOI: 10.1007/s11764-015-0513-4.Peer-Reviewed Original ResearchConceptsLong-term cancer survivorsCancer survivorsCare plansAmerican Cancer Society's StudySurvivorship care plansTime of diagnosisLong-term survivorsSelf-reported poor healthLate cancer stageHealth informationHealth care providersNon-Hispanic whitesCONCLUSIONS/IMPLICATIONSGreater informational needsMethodsCancer survivorsUsual careCancer characteristicsCancer patientsCommon cancerCancer stageTreatment summaryBreast cancerCare providersSurvey 9Younger age
2014
Novel gene identified in an exome‐wide association study of tanning dependence
Cartmel B, Dewan A, Ferrucci LM, Gelernter J, Stapleton J, Leffell DJ, Mayne ST, Bale AE. Novel gene identified in an exome‐wide association study of tanning dependence. Experimental Dermatology 2014, 23: 757-759. PMID: 25041255, PMCID: PMC4204712, DOI: 10.1111/exd.12503.Peer-Reviewed Original ResearchSkin and plasma carotenoid response to a provided intervention diet high in vegetables and fruit: uptake and depletion kinetics 1 , 2 , 3 , 4 5
Jahns L, Johnson LK, Mayne ST, Cartmel B, Picklo MJ, Ermakov IV, Gellermann W, Whigham LD. Skin and plasma carotenoid response to a provided intervention diet high in vegetables and fruit: uptake and depletion kinetics 1 , 2 , 3 , 4 5. American Journal Of Clinical Nutrition 2014, 100: 930-937. PMID: 25008856, DOI: 10.3945/ajcn.114.086900.Peer-Reviewed Original ResearchConceptsSkin carotenoid statusCarotenoid statusFruit intakeObjective biomarkersPlasma valuesTime pointsSkin carotenoid concentrationLow-carotenoid dietIntervention dietIntervention trialsUsual dietSkin carotenoidsFeeding interventionsPlasma carotenoidsGood biomarkerBaseline concentrationsBlood carotenoidsCarotenoid concentrations
2013
Indoor Tanning and Tanning Dependence in Young People After a Diagnosis of Basal Cell Carcinoma
Cartmel B, Ferrucci LM, Spain P, Bale AE, Pagoto SL, Leffell DJ, Gelernter J, Mayne ST. Indoor Tanning and Tanning Dependence in Young People After a Diagnosis of Basal Cell Carcinoma. JAMA Dermatology 2013, 149: 1110-1111. PMID: 23824273, PMCID: PMC3782995, DOI: 10.1001/jamadermatol.2013.5104.Peer-Reviewed Original Research