2023
Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila
Scott H, Novikov B, Ugur B, Allen B, Mertsalov I, Monagas-Valentin P, Koff M, Robinson S, Aoki K, Veizaj R, Lefeber D, Tiemeyer M, Bellen H, Panin V. Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila. ELife 2023, 12: e78280. PMID: 36946697, PMCID: PMC10110239, DOI: 10.7554/elife.78280.Peer-Reviewed Original ResearchConceptsSialylation pathwayCMP-sialic acid synthetaseStress toleranceAnimal developmentProtein functionVoltage-gated sodium channelsGlycan terminiNeural transmissionDedicated pathwaysGenesDifferent cellsPathwayOxidative stressSodium channelsSialic acidNervous systemNeural excitabilitySialylationToleranceNormal levelsNeural functionDrosophilaTerminusExcitabilitySynthetase
2022
Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila
Bosch J, Ugur B, Pichardo-Casas I, Rabasco J, Escobedo F, Zuo Z, Brown B, Celniker S, Sinclair D, Bellen H, Perrimon N. Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in Drosophila. ELife 2022, 11: e82709. PMID: 36346220, PMCID: PMC9681215, DOI: 10.7554/elife.82709.Peer-Reviewed Original ResearchConceptsSmall open reading framesClasses of genesShares sequence similarityOpen reading frameSequence similarityBicistronic transcriptBiological functionsPhenotypic analysisMitochondrial functionImportant regulatorThousands of peptidesNeuronal functionGenesWealth of informationTranscriptsAnimal lethalityPeptidesRecent studiesParalogsDrosophilaSmORFsMitochondriaRegulatorRegulatesNeuronal peptides