2023
A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke
Lyden P, Diniz M, Bosetti F, Lamb J, Nagarkatti K, Rogatko A, Kim S, Cabeen R, Koenig J, Akhter K, Arbab A, Avery B, Beatty H, Bibic A, Cao S, Simoes Braga Boisserand L, Chamorro A, Chauhan A, Diaz-Perez S, Dhandapani K, Dhanesha N, Goh A, Herman A, Hyder F, Imai T, Johnson C, Khan M, Kamat P, Karuppagounder S, Kumskova M, Mihailovic J, Mandeville J, Morais A, Patel R, Sanganahalli B, Smith C, Shi Y, Sutariya B, Thedens D, Qin T, Velazquez S, Aronowski J, Ayata C, Chauhan A, Leira E, Hess D, Koehler R, McCullough L, Sansing L. A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke. Science Translational Medicine 2023, 15: eadg8656. PMID: 37729432, DOI: 10.1126/scitranslmed.adg8656.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleHumansIschemic StrokeLaboratoriesMaleMiceRatsReproducibility of ResultsRodentiaStrokeConceptsPreclinical assessmentFocal cerebral ischemic insultAcute ischemic strokeCerebral ischemic insultLarge clinical trialsDiet-induced obesityNew clinical interventionsIntravascular thrombectomyIschemic strokeStroke treatmentHypertensive ratsIschemic insultBlinded assessmentClinical trialsYoung miceTreatment candidatesExclusion criteriaAnimal modelsYoung ratsFutile interventionsPreclinical trialsClinical interventionsFutility boundariesMiceDisease areas
2015
Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks
Kannurpatti SS, Sanganahalli BG, Herman P, Hyder F. Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks. NMR In Biomedicine 2015, 28: 1579-1588. PMID: 26439799, PMCID: PMC4621005, DOI: 10.1002/nbm.3421.Peer-Reviewed Original ResearchConceptsSimilar dose-dependent decreaseDose-dependent decreaseCaudate putamenBrain regionsBlood oxygen level-dependent fluctuationsBrain energy metabolismLevel-dependent fluctuationsBrain functional organizationSomatosensory cortexAnesthetized ratsDifferent functional networksFunctional organizationDrug treatmentVascular densityHippocampal regionThalamic regionsDifferent physiological impactsBOLD fluctuationsRSFC networksIntrinsic activityState fMRINeural signalingBrain networksPutamenFMRI brain networks
2013
Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging
Coman D, Sanganahalli BG, Cheng D, McCarthy T, Rothman DL, Hyder F. Mapping phosphorylation rate of fluoro-deoxy-glucose in rat brain by 19F chemical shift imaging. Magnetic Resonance Imaging 2013, 32: 305-313. PMID: 24581725, PMCID: PMC3965601, DOI: 10.1016/j.mri.2013.10.015.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBrainFluorodeoxyglucose F18Glucose-6-PhosphateMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMetabolic Clearance RateMolecular ImagingPhosphorylationPhosphotransferasesRadionuclide ImagingRadiopharmaceuticalsRatsRats, Inbred LewReproducibility of ResultsSensitivity and SpecificityTissue DistributionConceptsRat brainChemical shift imagingHalothane-anesthetized ratsMagnetic resonance spectroscopy studyTotal glucose metabolismMinimal side effectsMagnetic resonance imaging (MRI) measurementsFunctional magnetic resonance imaging (fMRI) measurementsFDG phosphorylationFMRI BOLD responsesCerebral physiologyForepaw stimulationShift imagingGlucose metabolismSide effectsBrain tissueFDGExtracted tissuesTumor pathophysiologyBrainMRS measurementsTissue componentsVivo detectionVivoD-glucose