2023
CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection
Prendergast A, Jim K, Marnas H, Desban L, Quan F, Djenoune L, Laghi V, Hocquemiller A, Lunsford E, Roussel J, Keiser L, Lejeune F, Dhanasekar M, Bardet P, Levraud J, van de Beek D, Vandenbroucke-Grauls C, Wyart C. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current Biology 2023, 33: 940-956.e10. PMID: 36791723, DOI: 10.1016/j.cub.2023.01.039.Peer-Reviewed Original ResearchConceptsCentral nervous systemCerebrospinal fluidSensory neuronsNervous systemStreptococcus pneumoniaeCentral nervous system infectionBlockade of neurotransmissionCentral sensory neuronsNervous system infectionHost survivalPeripheral nervous systemCell-specific ablationEpileptic-like seizuresCSF-contacting neuronsSupernatants of cellsPneumococcal meningitisSystem infectionBitter taste receptorsCSF infectionPneumoniae infectionNeurotropic virusesSpinal cordPathogenic bacteriaPostural controlMeningitis
2017
The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
Djenoune L, Desban L, Gomez J, Sternberg JR, Prendergast A, Langui D, Quan FB, Marnas H, Auer TO, Rio JP, Del Bene F, Bardet PL, Wyart C. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Scientific Reports 2017, 7: 719. PMID: 28389647, PMCID: PMC5428266, DOI: 10.1038/s41598-017-00350-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedAxonsBiomarkersCarrier ProteinsCell DifferentiationCerebrospinal FluidFluorescent Antibody TechniqueGanglia, SpinalHomozygoteMutationNeuronsSensory Receptor CellsSignal TransductionSpinal CordSpinal Nerve RootsTRPP Cation ChannelsZebrafishZebrafish ProteinsConceptsDual developmental originDevelopmental originsDistinct progenitor domainsApical extensionDistinct functional subtypesDifferent developmental originsCerebrospinal fluid-contacting neuronsTranscription factorsMechanical cuesZebrafish larvaeDistinct functionsProgenitor domainsCentral nervous systemCell typesDistinct cascadesFunctional populationsDifferent functional propertiesCSF-cNsNovel avenuesPKD2L1 channelFunctional subtypesSensory neuronsNeuronal targetsDistinct functional populationsSpecific markers
2016
Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion
Hubbard JM, Böhm UL, Prendergast A, Tseng PB, Newman M, Stokes C, Wyart C. Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion. Current Biology 2016, 26: 2841-2853. PMID: 27720623, DOI: 10.1016/j.cub.2016.08.026.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic currentsCSF-cNsSensory neuronsPostural controlMotor circuitsFast motor neuronsEscape circuitCerebrospinal fluid-contacting neuronsLarge inhibitory postsynaptic currentsGABAergic neuronsPostsynaptic currentsSpinal cordMotor neuronsVivo electrophysiologyRepetitive stimulationSomatic inhibitionSensory interneuronsNeuronsPowerful inhibitionInhibitory feedbackRecent evidenceVertebrate spinal cordMechanosensory responsesInhibitionInterneurons
2015
State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons
Fidelin K, Djenoune L, Stokes C, Prendergast A, Gomez J, Baradel A, Del Bene F, Wyart C. State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons. Current Biology 2015, 25: 3035-3047. PMID: 26752076, DOI: 10.1016/j.cub.2015.09.070.Peer-Reviewed Original ResearchConceptsLocomotor central pattern generatorSensory neuronsCerebrospinal fluidCSF-cNsSpinal cordCentral pattern generatorSpinal sensory neuronsActivity of neuronsEntire nervous systemState-dependent modulationGABAergic synapsesSlow locomotionGlutamatergic interneuronsPremotor levelState-dependent mannerNervous systemFunctional connectivityRostrocaudal propagationNeuronsVertebrate spinal cordSelective activationCordEpithelial boundaryActivationFictive preparation
2012
Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling
McGraw HF, Snelson CD, Prendergast A, Suli A, Raible DW. Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling. Neural Development 2012, 7: 23. PMID: 22738203, PMCID: PMC3438120, DOI: 10.1186/1749-8104-7-23.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedGanglia, SpinalGene Expression Regulation, DevelopmentalHomeodomain ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsNeural CrestNeurogenesisNeuronsReceptor, Notch1Signal TransductionZebrafishZebrafish ProteinsConceptsLarval developmentNotch signalingDorsal root gangliaTransgenic zebrafish lineNeural crest migrationLate larval developmentNeural crest cellsFate-mapping experimentsNeuronal additionVertebrate embryosZebrafish lineCellular regulationCrest migrationProgenitor populationsCrest cellsDRG formationRoot gangliaNew neuronsConditional inhibitionProgenitor cellsSignalingDRG neuronsSensory neuronsPopulation of residentsNeurons