2020
Experience, circuit dynamics and forebrain recruitment in larval zebrafish prey capture
Oldfield C, Grossrubatscher I, Chávez M, Hoagland A, Huth A, Carroll E, Prendergast A, Qu T, Gallant J, Wyart C, Isacoff E. Experience, circuit dynamics and forebrain recruitment in larval zebrafish prey capture. ELife 2020, 9: e56619. PMID: 32985972, PMCID: PMC7561350, DOI: 10.7554/elife.56619.Peer-Reviewed Original Research
2019
Glia: A Gate Controlling Animal Behavior?
Wyart C, Prendergast A. Glia: A Gate Controlling Animal Behavior? Current Biology 2019, 29: r847-r850. PMID: 31505186, DOI: 10.1016/j.cub.2019.07.058.Peer-Reviewed Original Research
2018
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Sternberg JR, Prendergast AE, Brosse L, Cantaut-Belarif Y, Thouvenin O, Orts-Del’Immagine A, Castillo L, Djenoune L, Kurisu S, McDearmid JR, Bardet PL, Boccara C, Okamoto H, Delmas P, Wyart C. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9: 3804. PMID: 30228263, PMCID: PMC6143598, DOI: 10.1038/s41467-018-06225-x.Peer-Reviewed Original ResearchConceptsCentral canalCSF-cNsSpontaneous activityCSF flowCerebrospinal fluid-contacting neuronsSpine curvatureCSF-contacting neuronsCerebrospinal fluid flowSpinal cordIdiopathic scoliosisSingle-channel openingsCalcium activityPKD2L1 channelPKD2L1Mechanosensory cellsNeuronsCanalChannel openingMechanoceptionKyphosisCilia motilityCord
2017
Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae.
Knafo S, Prendergast A, Thouvenin O, Figueiredo SN, Wyart C. Bioluminescence Monitoring of Neuronal Activity in Freely Moving Zebrafish Larvae. Bio-protocol 2017, 7: e2550. PMID: 29130058, PMCID: PMC5681248, DOI: 10.21769/bioprotoc.2550.Peer-Reviewed Original ResearchMechanosensory neurons control the timing of spinal microcircuit selection during locomotion
Knafo S, Fidelin K, Prendergast A, Tseng PB, Parrin A, Dickey C, Böhm UL, Figueiredo SN, Thouvenin O, Pascal-Moussellard H, Wyart C. Mechanosensory neurons control the timing of spinal microcircuit selection during locomotion. ELife 2017, 6: e25260. PMID: 28623664, PMCID: PMC5499942, DOI: 10.7554/elife.25260.Peer-Reviewed Original ResearchConceptsSpinal cordMechanosensory neuronsRohon-Beard neuronsMonosynaptic inputSpinal circuitsMotor poolsCordNeuronsV2a interneuronsVertebrate spinal cordMechanosensory feedbackNumerous physiological studiesSimple locomotionPhysiological studiesActive locomotionLocomotor speedEscape responseInterneuronsZebrafish larvae
2016
Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion
Hubbard JM, Böhm UL, Prendergast A, Tseng PB, Newman M, Stokes C, Wyart C. Intraspinal Sensory Neurons Provide Powerful Inhibition to Motor Circuits Ensuring Postural Control during Locomotion. Current Biology 2016, 26: 2841-2853. PMID: 27720623, DOI: 10.1016/j.cub.2016.08.026.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic currentsCSF-cNsSensory neuronsPostural controlMotor circuitsFast motor neuronsEscape circuitCerebrospinal fluid-contacting neuronsLarge inhibitory postsynaptic currentsGABAergic neuronsPostsynaptic currentsSpinal cordMotor neuronsVivo electrophysiologyRepetitive stimulationSomatic inhibitionSensory interneuronsNeuronsPowerful inhibitionInhibitory feedbackRecent evidenceVertebrate spinal cordMechanosensory responsesInhibitionInterneuronsCSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits
Böhm UL, Prendergast A, Djenoune L, Nunes Figueiredo S, Gomez J, Stokes C, Kaiser S, Suster M, Kawakami K, Charpentier M, Concordet JP, Rio JP, Del Bene F, Wyart C. CSF-contacting neurons regulate locomotion by relaying mechanical stimuli to spinal circuits. Nature Communications 2016, 7: 10866. PMID: 26946992, PMCID: PMC4786674, DOI: 10.1038/ncomms10866.Peer-Reviewed Original ResearchConceptsSpinal cordSpinal circuitsCentral pattern generatorCSF-cNsCerebrospinal fluid-contacting neuronsSpinal central pattern generatorVentral spinal cordLocomotor central pattern generatorCSF-contacting neuronsCentral canalSpinal bendingCordNeuronsMechanical stimuliMechanosensory organsOrgansSensory modalitiesAnimalsLocomotion: Electrical Coupling of Motor and Premotor Neurons
Prendergast A, Wyart C. Locomotion: Electrical Coupling of Motor and Premotor Neurons. Current Biology 2016, 26: r235-r237. PMID: 27003886, DOI: 10.1016/j.cub.2016.02.021.Peer-Reviewed Original Research
2015
State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons
Fidelin K, Djenoune L, Stokes C, Prendergast A, Gomez J, Baradel A, Del Bene F, Wyart C. State-Dependent Modulation of Locomotion by GABAergic Spinal Sensory Neurons. Current Biology 2015, 25: 3035-3047. PMID: 26752076, DOI: 10.1016/j.cub.2015.09.070.Peer-Reviewed Original ResearchConceptsLocomotor central pattern generatorSensory neuronsCerebrospinal fluidCSF-cNsSpinal cordCentral pattern generatorSpinal sensory neuronsActivity of neuronsEntire nervous systemState-dependent modulationGABAergic synapsesSlow locomotionGlutamatergic interneuronsPremotor levelState-dependent mannerNervous systemFunctional connectivityRostrocaudal propagationNeuronsVertebrate spinal cordSelective activationCordEpithelial boundaryActivationFictive preparation
2012
Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling
McGraw HF, Snelson CD, Prendergast A, Suli A, Raible DW. Postembryonic neuronal addition in Zebrafish dorsal root ganglia is regulated by Notch signaling. Neural Development 2012, 7: 23. PMID: 22738203, PMCID: PMC3438120, DOI: 10.1186/1749-8104-7-23.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedGanglia, SpinalGene Expression Regulation, DevelopmentalHomeodomain ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsNerve Tissue ProteinsNeural CrestNeurogenesisNeuronsReceptor, Notch1Signal TransductionZebrafishZebrafish ProteinsConceptsLarval developmentNotch signalingDorsal root gangliaTransgenic zebrafish lineNeural crest migrationLate larval developmentNeural crest cellsFate-mapping experimentsNeuronal additionVertebrate embryosZebrafish lineCellular regulationCrest migrationProgenitor populationsCrest cellsDRG formationRoot gangliaNew neuronsConditional inhibitionProgenitor cellsSignalingDRG neuronsSensory neuronsPopulation of residentsNeurons