2024
Estimating the lives that could be saved by expanded access to weight-loss drugs
Pandey A, Ye Y, Wells C, Singer B, Galvani A. Estimating the lives that could be saved by expanded access to weight-loss drugs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2412872121. PMID: 39405358, PMCID: PMC11513960, DOI: 10.1073/pnas.2412872121.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Body mass index categoriesObesity prevalence dataGlucagon-like peptide-1 receptor agonistsHazard ratio of mortalityRatio of mortalityPublic health impactWeight loss drugsInsurance coverage issuesGastric inhibitory polypeptideHealthcare accessType 2 diabetesUnited StatesPublic health crisisObesity epidemicReceptor agonistsIndex categoriesHazard ratioPrevalence dataInhibitory polypeptidePeptide-1Health impactsNovel treatmentObesityHealth crisisA retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients
Du Z, Wang L, Bai Y, Liu Y, Lau E, Galvani A, Krug R, Cowling B, Meyers L. A retrospective cohort study of Paxlovid efficacy depending on treatment time in hospitalized COVID-19 patients. ELife 2024, 13: e89801. PMID: 38622989, PMCID: PMC11078542, DOI: 10.7554/elife.89801.Peer-Reviewed Original ResearchConceptsViral sheddingHospitalized COVID-19 patientsSARS-CoV-2Retrospective cohort studyRisk of reboundCOVID-19 patientsViral reboundTime of treatmentTreated patientsPreventing severe illnessEarly treatmentCohort studyHospitalized patientsPatientsViral replicationReducing infectiousnessSevere illnessTimely treatmentViral dynamicsHealth record dataTreatmentTransmission riskTransmission of SARS-CoV-2EfficacySymptoms
2015
The Impact of Enhanced Screening and Treatment on Hepatitis C in the United States
Durham DP, Skrip LA, Bruce RD, Vilarinho S, Elbasha EH, Galvani AP, Townsend JP. The Impact of Enhanced Screening and Treatment on Hepatitis C in the United States. Clinical Infectious Diseases 2015, 62: 298-304. PMID: 26628566, PMCID: PMC4706637, DOI: 10.1093/cid/civ894.Peer-Reviewed Original ResearchConceptsHepatitis C virusInterferon-free DAAsHCV incidenceTreatment ratesChronic hepatitis C virusCases of cirrhosisInjection drug useImpact of administrationAnnual treatment ratesEnhanced screeningHCV prevalenceHCV screeningDecompensated cirrhosisHCV infectionHCV transmissionHepatitis CLiver transplantActing antiviralsLevels of screeningPatients 4C virusHepatocellular carcinomaEpidemiological dataUniversal screeningDrug use
2009
Optimizing Influenza Vaccine Distribution
Medlock J, Galvani AP. Optimizing Influenza Vaccine Distribution. Science 2009, 325: 1705-1708. PMID: 19696313, DOI: 10.1126/science.1175570.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedCenters for Disease Control and Prevention, U.S.ChildChild, PreschoolDisease OutbreaksHealth PolicyHumansImmunization ProgramsInfantInfluenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInfluenza, HumanMiddle AgedModels, StatisticalUnited StatesVaccinationYoung AdultConceptsOutcome measuresNovel swine-origin influenzaOptimal vaccine allocationInfluenza vaccine distributionContingent valuationSwine-origin influenzaYears of lifePublic health policyOptimal allocationEconomic costsInfluenza vaccineSeasonal influenzaInfluenza pandemicU.S. CentersVaccine allocationDisease controlMortality dataVaccine distributionHealth policyOptimal vaccinationPolicy optimizationTransmission dynamicsInfluenzaAllocationNew recommendations
2007
Long-standing influenza vaccination policy is in accord with individual self-interest but not with the utilitarian optimum
Galvani AP, Reluga TC, Chapman GB. Long-standing influenza vaccination policy is in accord with individual self-interest but not with the utilitarian optimum. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 5692-5697. PMID: 17369367, PMCID: PMC1838447, DOI: 10.1073/pnas.0606774104.Peer-Reviewed Original ResearchConceptsInfluenza vaccinationInfluenza vaccination policiesVaccine allocation strategiesEpidemic influenzaPandemic influenzaInfluenza mortalityVaccination levelsVaccination programVaccination strategiesVaccination policyInfluenza transmissionVaccinationGreater riskDisease controlInfluenzaMortalityChildrenQuestionnaire dataMorbidityVaccine
2003
Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ32 HIV-resistance allele
Galvani AP, Slatkin M. Evaluating plague and smallpox as historical selective pressures for the CCR5-Δ32 HIV-resistance allele. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 15276-15279. PMID: 14645720, PMCID: PMC299980, DOI: 10.1073/pnas.2435085100.Peer-Reviewed Original Research