2021
Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cells
Jiang R, Meng H, Raddassi K, Fleming I, Hoehn KB, Dardick KR, Belperron AA, Montgomery RR, Shalek AK, Hafler DA, Kleinstein SH, Bockenstedt LK. Single cell immunophenotyping of the skin lesion erythema migrans Identifies IgM memory B cells. JCI Insight 2021, 6: e148035. PMID: 34061047, PMCID: PMC8262471, DOI: 10.1172/jci.insight.148035.Peer-Reviewed Original ResearchConceptsMemory B cellsErythema migransB cellsEM lesionsIgM memory B cellsLyme diseaseB-cell receptor sequencingSkin infection siteCell receptor sequencingEarly Lyme diseaseLocal antigen presentationSkin immune responsesB cell populationsSingle-cell immunophenotypingMHC class II genesUninvolved skinImmune cellsSpirochetal infectionAntigen presentationCell immunophenotypingT cellsImmune responseIsotype usageAntibody productionInitial signs
2003
Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected γδ T-Cell-Deficient Mice
Bockenstedt LK, Shanafelt MC, Belperron A, Mao J, Barthold SW. Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected γδ T-Cell-Deficient Mice. Infection And Immunity 2003, 71: 2938-2940. PMID: 12704174, PMCID: PMC153287, DOI: 10.1128/iai.71.5.2938-2940.2003.Peer-Reviewed Original ResearchConceptsΓδ T-cell-deficient miceT cell-deficient miceGamma delta T cellsGamma delta T-cell functionGamma delta TBorrelia burgdorferiDelta T cellsMurine Lyme borreliosisT cell functionHumoral immunityHumoral responseAntibody isotypesT cellsLyme borreliosisCell biasDisease susceptibilityArthropod transmissionBurgdorferi
2000
Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi
Kumar H, Belperron A, Barthold S, Bockenstedt L. Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi. The Journal Of Immunology 2000, 165: 4797-4801. PMID: 11046002, DOI: 10.4049/jimmunol.165.9.4797.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialAntigens, CD1Antigens, CD1dAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupDNA, BacterialGenetic Predisposition to DiseaseImmunity, InnateImmunoglobulin GLipoproteinsLyme DiseaseLyme Disease VaccinesMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutUrinary BladderConceptsLipid AgsHost defenseCD1d-deficient miceDisease-susceptible miceMurine host defenseRole of CD1dImpair host resistanceBorrelia burgdorferiSusceptible mouse strainsControl miceT cellsCD1 moleculesSpirochete DNADisease profileMouse strainsMiceLyme disease spirocheteInfectionSpirochetesBurgdorferiHost resistancePathogensArthritisCD1dEnhanced production