2017
Two Photon Intravital Microscopy of Lyme Borrelia in Mice
Belperron AA, Mao J, Bockenstedt LK. Two Photon Intravital Microscopy of Lyme Borrelia in Mice. Methods In Molecular Biology 2017, 1690: 279-290. PMID: 29032551, DOI: 10.1007/978-1-4939-7383-5_20.Peer-Reviewed Original ResearchVancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium
Harman MW, Hamby AE, Boltyanskiy R, Belperron AA, Bockenstedt LK, Kress H, Dufresne ER, Wolgemuth CW. Vancomycin Reduces Cell Wall Stiffness and Slows Swim Speed of the Lyme Disease Bacterium. Biophysical Journal 2017, 112: 746-754. PMID: 28256234, PMCID: PMC5340155, DOI: 10.1016/j.bpj.2016.12.039.Peer-Reviewed Original ResearchConceptsCell wall stiffnessCell wallCell stiffnessCell speedLyme disease bacteriumSpirochete survivalPeriplasmic volumeCell shapeFlat wave shapeSwim speedTick hostsCell growthCell morphologyDisease bacteriumVolume regulationHost tissuesTestable hypothesesPrevious mathematical modelingBleb formationSublethal dosesMotilityBiophysical modelSwimming speedBorrelia burgdorferiSlower swim speed
2014
Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States
Dunn JM, Krause PJ, Davis S, Vannier EG, Fitzpatrick MC, Rollend L, Belperron AA, States SL, Stacey A, Bockenstedt LK, Fish D, Diuk-Wasser MA. Borrelia burgdorferi Promotes the Establishment of Babesia microti in the Northeastern United States. PLOS ONE 2014, 9: e115494. PMID: 25545393, PMCID: PMC4278703, DOI: 10.1371/journal.pone.0115494.Peer-Reviewed Original ResearchConceptsB. microtiB. burgdorferiBabesia microtiLyme diseaseRespective causative agentsSpread of babesiosisI. scapularis larvaeInfected micePrimary reservoir hostHigh prevalenceLeucopus miceMiceHuman babesiosisBorrelia burgdorferiLaboratory dataLarval burdenCausative agentMicrotiBurgdorferiCoinfectionReservoir hostsDiseaseR0 modelBasic reproduction numberEnzootic cycleDual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice
Belperron AA, Liu N, Booth CJ, Bockenstedt LK. Dual role for Fcγ receptors in host defense and disease in Borrelia burgdorferi-infected mice. Frontiers In Cellular And Infection Microbiology 2014, 4: 75. PMID: 24967215, PMCID: PMC4052197, DOI: 10.3389/fcimb.2014.00075.Peer-Reviewed Original ResearchConceptsInnate immune cellsWild-type miceB. burgdorferi infectionB. burgdorferi-infected miceBurgdorferi-infected miceImmune cellsBurgdorferi infectionType micePathogen burdenHost defenseFc receptor common gamma chainIgG-mediated clearanceC-reactive proteinBorrelia burgdorferiToll-Like Receptor InteractionsSingle knockout miceCommon gamma chainAcute phaseInfected jointsArthritis severityMolecule MyD88Inflammatory cytokinesInflammatory pathwaysIL-1betaReactive protein
2009
The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis
Liu N, Belperron AA, Booth CJ, Bockenstedt LK. The Caspase 1 Inflammasome Is Not Required for Control of Murine Lyme Borreliosis. Infection And Immunity 2009, 77: 3320-3327. PMID: 19487481, PMCID: PMC2715671, DOI: 10.1128/iai.00100-09.Peer-Reviewed Original ResearchConceptsCaspase-1 inflammasomeCaspase-1Immune responseHost defenseLyme borreliosisToll-like receptor-mediated responsesDay 14 postinfectionPrevalence of arthritisT cell responsesApoptosis-associated speck-like proteinMild transient elevationBorrelia burgdorferiMurine Lyme borreliosisReceptor-mediated responsesCaspase-1 deficiencyC-terminal caspase recruitment domainSpeck-like proteinAbility of macrophagesEnzyme caspase-1IL-18Humoral immunityInterleukin-1betaTransient elevationPathogen burdenInflammasome
2003
Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected γδ T-Cell-Deficient Mice
Bockenstedt LK, Shanafelt MC, Belperron A, Mao J, Barthold SW. Humoral Immunity Reflects Altered T Helper Cell Bias in Borrelia burgdorferi-Infected γδ T-Cell-Deficient Mice. Infection And Immunity 2003, 71: 2938-2940. PMID: 12704174, PMCID: PMC153287, DOI: 10.1128/iai.71.5.2938-2940.2003.Peer-Reviewed Original ResearchConceptsΓδ T-cell-deficient miceT cell-deficient miceGamma delta T cellsGamma delta T-cell functionGamma delta TBorrelia burgdorferiDelta T cellsMurine Lyme borreliosisT cell functionHumoral immunityHumoral responseAntibody isotypesT cellsLyme borreliosisCell biasDisease susceptibilityArthropod transmissionBurgdorferi
2000
Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi
Kumar H, Belperron A, Barthold S, Bockenstedt L. Cutting Edge: CD1d Deficiency Impairs Murine Host Defense Against the Spirochete, Borrelia burgdorferi. The Journal Of Immunology 2000, 165: 4797-4801. PMID: 11046002, DOI: 10.4049/jimmunol.165.9.4797.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, BacterialAntigens, BacterialAntigens, CD1Antigens, CD1dAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferi GroupDNA, BacterialGenetic Predisposition to DiseaseImmunity, InnateImmunoglobulin GLipoproteinsLyme DiseaseLyme Disease VaccinesMiceMice, Inbred C3HMice, Inbred C57BLMice, KnockoutUrinary BladderConceptsLipid AgsHost defenseCD1d-deficient miceDisease-susceptible miceMurine host defenseRole of CD1dImpair host resistanceBorrelia burgdorferiSusceptible mouse strainsControl miceT cellsCD1 moleculesSpirochete DNADisease profileMouse strainsMiceLyme disease spirocheteInfectionSpirochetesBurgdorferiHost resistancePathogensArthritisCD1dEnhanced production