The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines
Rezaeian A, Khatami F, Heidari Keshel S, Akbari M, Mirzaei A, Gholami K, Mohammadi Farsani R, Aghamir S. The effect of mesenchymal stem cells-derived exosomes on the prostate, bladder, and renal cancer cell lines. Scientific Reports 2022, 12: 20924. PMID: 36463254, PMCID: PMC9719468, DOI: 10.1038/s41598-022-23204-x.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorEpithelial-Mesenchymal TransitionExosomesHormonesHumansKidney NeoplasmsMaleMesenchymal Stem CellsProstateProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53Urinary BladderVascular Endothelial Growth Factor CConceptsExpression of epithelial to mesenchymal transitionCancer cell linesProstate cancerMesenchymal stem cells-derived exosomesCell linesCells-derived exosomesHormone-refractory prostate cancerMSC-exosomesKidney cancer cell linesPercentage of apoptotic cellsProliferation of cancer cellsDecreased Bcl2 expressionEpithelial to mesenchymal transitionAnti-angiogenic effectsRenal cancer cell linesGene expression changesRealtime PCR methodKidney tumor cell lineOsteopontin variantsTumor cell linesVEGF-CAntitumor effectBladder cancerHormone-sensitiveRenal cancer